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, and Anti-Inflammatory Agents1
*
Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, and
Servicio de Inmuno-oncología and
Servicio de Inmunología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN) is a
monocyte-derived dendritic cell (MDDC)-specific lectin which
participates in dendritic cell (DC) migration and DC-T lymphocyte
interactions at the initiation of immune responses and enhances
trans-infection of T cells through its HIV gp120-binding
ability. The generation of a DC-SIGN-specific mAb has allowed us to
determine that the acquisition of DC-SIGN expression during the
monocyte-DC differentiation pathway is primarily induced by IL-4, and
that GM-CSF cooperates with IL-4 to generate a high level of DC-SIGN
mRNA and cell surface expression on immature MDDC. IL-4 was capable of
inducing DC-SIGN expression on monocytes without affecting the
expression of other MDDC differentiation markers. By contrast, IFN-
,
IFN-
, and TGF-
were identified as negative regulators of DC-SIGN
expression, as they prevented the IL-4-dependent induction of DC-SIGN
mRNA on monocytes, and a similar inhibitory effect was exerted by
dexamethasone, an inhibitor of the monocyte-MDDC differentiation
pathway. The relevance of the inhibitory action of dexamethasone, IFN,
and TGF- on DC-SIGN expression was emphasized by their ability to
inhibit the DC-SIGN-dependent HIV-1 binding to differentiating MDDC.
These results demonstrate that DC-SIGN, considered as a MDDC
differentiation marker, is a molecule specifically expressed on
IL-4-treated monocytes, and whose expression is subjected to a tight
regulation by numerous cytokines and growth factors. This feature might
help in the development of strategies to modulate the DC-SIGN-dependent
cell surface attachment of HIV for therapeutic
purposes.
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N. Sanchez-Sanchez, L. Riol-Blanco, G. de la Rosa, A. Puig-Kroger, J. Garcia-Bordas, D. Martin, N. Longo, A. Cuadrado, C. Cabanas, A. L. Corbi, et al. Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells Blood, August 1, 2004; 104(3): 619 - 625. [Abstract] [Full Text] [PDF]
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M. J.-Y. Ploquin, O. M. Diop, N. Sol-Foulon, L. Mortara, A. Faye, M. A. Soares, E. Nerrienet, R. Le Grand, Y. Van Kooyk, A. Amara, et al. DC-SIGN from African Green Monkeys Is Expressed in Lymph Nodes and Mediates Infection in trans of Simian Immunodeficiency Virus SIVagm J. Virol., January 15, 2004; 78(2): 798 - 810. [Abstract] [Full Text] [PDF]
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M. Colmenares, A. L. Corbi, S. J. Turco, and L. Rivas The Dendritic Cell Receptor DC-SIGN Discriminates among Species and Life Cycle Forms of Leishmania J. Immunol., January 15, 2004; 172(2): 1186 - 1190. [Abstract] [Full Text] [PDF]
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 F. Lasala, E. Arce, J. R. Otero, J. Rojo, and R. Delgado Mannosyl Glycodendritic Structure Inhibits DC-SIGN-Mediated Ebola Virus Infection in cis and in trans Antimicrob. Agents Chemother., December 1, 2003; 47(12): 3970 - 3972. [Abstract] [Full Text] [PDF]
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W. B. Klimstra, E. M. Nangle, M. S. Smith, A. D. Yurochko, and K. D. Ryman DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses J. Virol., November 15, 2003; 77(22): 12022 - 12032. [Abstract] [Full Text] [PDF]
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J. Chehimi, Q. Luo, L. Azzoni, L. Shawver, N. Ngoubilly, R. June, G. Jerandi, M. Farabaugh, and L. J. Montaner HIV-1 transmission and cytokine-induced expression of DC-SIGN in human monocyte-derived macrophages J. Leukoc. Biol., November 1, 2003; 74(5): 757 - 763. [Abstract] [Full Text] [PDF]
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J. A. Willment, H.-H. Lin, D. M. Reid, P. R. Taylor, D. L. Williams, S. Y. C. Wong, S. Gordon, and G. D. Brown Dectin-1 Expression and Function Are Enhanced on Alternatively Activated and GM-CSF-Treated Macrophages and Are Negatively Regulated by IL-10, Dexamethasone, and Lipopolysaccharide J. Immunol., November 1, 2003; 171(9): 4569 - 4573. [Abstract] [Full Text] [PDF]
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A. K. De, K. Laudanski, and C. L. Miller-Graziano Failure of Monocytes of Trauma Patients to Convert to Immature Dendritic Cells is Related to Preferential Macrophage-Colony-Stimulating Factor-Driven Macrophage Differentiation J. Immunol., June 15, 2003; 170(12): 6355 - 6362. [Abstract] [Full Text] [PDF]
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A. Puig-Kroger, O. Muniz-Pello, R. Selgas, G. Criado, M-A. Bajo, J. A. Sanchez-Tomero, V. Alvarez, G. del Peso, P. Sanchez-Mateos, C. Holmes, et al. Peritoneal dialysis solutions inhibit the differentiation and maturation of human monocyte-derived dendritic cells: effect of lactate and glucose-degradation products J. Leukoc. Biol., April 1, 2003; 73(4): 482 - 492. [Abstract] [Full Text] [PDF]
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 L. Tailleux, O. Schwartz, J.-L. Herrmann, E. Pivert, M. Jackson, A. Amara, L. Legres, D. Dreher, L. P. Nicod, J. C. Gluckman, et al. DC-SIGN Is the Major Mycobacterium tuberculosis Receptor on Human Dendritic Cells J. Exp. Med., January 6, 2003; 197(1): 121 - 127. [Abstract] [Full Text] [PDF]
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E. J. Ryan, A. J. Marshall, D. Magaletti, H. Floyd, K. E. Draves, N. E. Olson, and E. A. Clark Dendritic Cell-Associated Lectin-1: A Novel Dendritic Cell-Associated, C-Type Lectin-Like Molecule Enhances T Cell Secretion of IL-4 J. Immunol., November 15, 2002; 169(10): 5638 - 5648. [Abstract] [Full Text] [PDF]
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M. Colmenares, A. Puig-Kroger, O. M. Pello, A. L. Corbi, and L. Rivas Dendritic Cell (DC)-specific Intercellular Adhesion Molecule 3 (ICAM-3)-grabbing Nonintegrin (DC-SIGN, CD209), a C-type Surface Lectin in Human DCs, Is a Receptor for Leishmania Amastigotes J. Biol. Chem., September 20, 2002; 277(39): 36766 - 36769. [Abstract] [Full Text] [PDF]
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C. P. Alvarez, F. Lasala, J. Carrillo, O. Muniz, A. L. Corbi, and R. Delgado C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans J. Virol., June 5, 2002; 76(13): 6841 - 6844. [Abstract] [Full Text] [PDF]
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 I. Melero, I. Gabari, A. L. Corbi, M. Relloso, G. Mazzolini, V. Schmitz, M. Rodriguez-Calvillo, I. Tirapu, E. Camafeita, J. P. Albar, et al. An Anti-ICAM-2 (CD102) Monoclonal Antibody Induces Immune-mediated Regressions of Transplanted ICAM-2-negative Colon Carcinomas Cancer Res., June 1, 2002; 62(11): 3167 - 3174. [Abstract] [Full Text] [PDF]
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