The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Robbins, S. H.
Right arrow Articles by Brossay, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Robbins, S. H.
Right arrow Articles by Brossay, L.
The Journal of Immunology, 2002, 168: 2585-2589.
Copyright © 2002 by The American Association of Immunologists

Cutting Edge

Cutting Edge: Inhibitory Functions of the Killer Cell Lectin-Like Receptor G1 Molecule During the Activation of Mouse NK Cells1

Scott H. Robbins*, Khuong B. Nguyen*, Nobuaki Takahashi{dagger}, Toshifumi Mikayama{dagger}, Christine A. Biron* and Laurent Brossay2,*

* Department of Molecular Microbiology and Immunology and Graduate Program in Pathobiology, Division of Biology and Medicine, Brown University, Providence, RI 02912; and {dagger} Gemini Science, San Diego, CA 92121

The killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated Ag and contains an immunoreceptor tyrosine-based inhibitory motif in its cytoplasmic domain. In this study we demonstrate that both pathogenic and nonpathogenic in vivo activation of NK cells induces the expression of KLRG1 on their cell surface. Upon infection with murine CMV, this induction peaks between days 5 and 7 with ~90% of the NK cells expressing KLRG1. On day 1.5 post-murine CMV infection of C57BL/6 mice, the main producers of IFN-{gamma} are the KLRG1-negative NK cells. This effect has been recapitulated in vitro as we show that engagement of KLRG1 on a transfected NK cell line inhibits both cytokine production and NK cell-mediated cytotoxicity. Taken together, these data illustrate the crucial role played by KLRG1 during the termination of mouse NK cell activation.




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
S. Nakamura, K. Kuroki, I. Ohki, K. Sasaki, M. Kajikawa, T. Maruyama, M. Ito, Y. Kameda, M. Ikura, K. Yamamoto, et al.
Molecular Basis for E-cadherin Recognition by Killer Cell Lectin-like Receptor G1 (KLRG1)
J. Biol. Chem., October 2, 2009; 284(40): 27327 - 27335.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. M. Henson, O. Franzese, R. Macaulay, V. Libri, R. I. Azevedo, S. Kiani-Alikhan, F. J. Plunkett, J. E. Masters, S. Jackson, S. J. Griffiths, et al.
KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells
Blood, June 25, 2009; 113(26): 6619 - 6628.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Yadi, S. Burke, Z. Madeja, M. Hemberger, A. Moffett, and F. Colucci
Unique Receptor Repertoire in Mouse Uterine NK cells
J. Immunol., November 1, 2008; 181(9): 6140 - 6147.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. D. Huntington, H. Tabarias, K. Fairfax, J. Brady, Y. Hayakawa, M. A. Degli-Esposti, M. J. Smyth, D. M. Tarlinton, and S. L. Nutt
NK Cell Maturation and Peripheral Homeostasis Is Associated with KLRG1 Up-Regulation
J. Immunol., April 15, 2007; 178(8): 4764 - 4770.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. S. Tessmer, C. Fugere, F. Stevenaert, O. V. Naidenko, H. J. Chong, G. Leclercq, and L. Brossay
KLRG1 binds cadherins and preferentially associates with SHIP-1
Int. Immunol., April 1, 2007; 19(4): 391 - 400.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Masopust, S.-J. Ha, V. Vezys, and R. Ahmed
Stimulation History Dictates Memory CD8 T Cell Phenotype: Implications for Prime-Boost Vaccination
J. Immunol., July 15, 2006; 177(2): 831 - 839.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. S. Franki, K. Van Beneden, P. Dewint, K. J. L. Hammond, S. Lambrecht, G. Leclercq, M. Kronenberg, D. Deforce, and D. Elewaut
A unique lymphotoxin {alpha}beta-dependent pathway regulates thymic emigration of V{alpha}14 invariant natural killer T cells
PNAS, June 13, 2006; 103(24): 9160 - 9165.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. H. Vesper, L. T. Raetzman, and S. A. Camper
Role of Prophet of Pit1 (PROP1) in Gonadotrope Differentiation and Puberty
Endocrinology, April 1, 2006; 147(4): 1654 - 1663.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. Ito, T. Maruyama, N. Saito, S. Koganei, K. Yamamoto, and N. Matsumoto
Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity
J. Exp. Med., February 21, 2006; 203(2): 289 - 295.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. Colonna
Cytolytic responses: cadherins put out the fire
J. Exp. Med., February 20, 2006; 203(2): 261 - 264.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Grundemann, M. Bauer, O. Schweier, N. von Oppen, U. Lassing, P. Saudan, K.-F. Becker, K. Karp, T. Hanke, M. F. Bachmann, et al.
Cutting Edge: Identification of E-Cadherin as a Ligand for the Murine Killer Cell Lectin-Like Receptor G1
J. Immunol., February 1, 2006; 176(3): 1311 - 1315.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Hayakawa and M. J. Smyth
CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory Capacity
J. Immunol., February 1, 2006; 176(3): 1517 - 1524.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. C. Ibegbu, Y.-X. Xu, W. Harris, D. Maggio, J. D. Miller, and A. P. Kourtis
Expression of Killer Cell Lectin-Like Receptor G1 on Antigen-Specific Human CD8+ T Lymphocytes during Active, Latent, and Resolved Infection and its Relation with CD57
J. Immunol., May 15, 2005; 174(10): 6088 - 6094.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Eberl, R. Engel, S. Aberle, P. Fisch, H. Jomaa, and H. Pircher
Human V{gamma}9/V{delta}2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1)
J. Leukoc. Biol., January 1, 2005; 77(1): 67 - 70.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Y. Han, M. Zhang, N. Li, T. Chen, Y. Zhang, T. Wan, and X. Cao
KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity
Blood, November 1, 2004; 104(9): 2858 - 2866.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. H. Robbins, M. S. Tessmer, T. Mikayama, and L. Brossay
Expansion and Contraction of the NK Cell Compartment in Response to Murine Cytomegalovirus Infection
J. Immunol., July 1, 2004; 173(1): 259 - 266.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Brady, Y. Hayakawa, M. J. Smyth, and S. L. Nutt
IL-21 Induces the Functional Maturation of Murine NK Cells
J. Immunol., February 15, 2004; 172(4): 2048 - 2058.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. H. Robbins, S. C. Terrizzi, B. C. Sydora, T. Mikayama, and L. Brossay
Differential Regulation of Killer Cell Lectin-Like Receptor G1 Expression on T Cells
J. Immunol., June 15, 2003; 170(12): 5876 - 5885.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. Dalod, T. Hamilton, R. Salomon, T. P. Salazar-Mather, S. C. Henry, J. D. Hamilton, and C. A. Biron
Dendritic Cell Responses to Early Murine Cytomegalovirus Infection: Subset Functional Specialization and Differential Regulation by Interferon {alpha}/{beta}
J. Exp. Med., April 7, 2003; 197(7): 885 - 898.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
V. J. Cavanaugh, Y. Deng, M. P. Birkenbach, J. S. Slater, and A. E. Campbell
Vigorous Innate and Virus-Specific Cytotoxic T-Lymphocyte Responses to Murine Cytomegalovirus in the Submaxillary Salivary Gland
J. Virol., February 1, 2003; 77(3): 1703 - 1717.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Voehringer, M. Koschella, and H. Pircher
Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)
Blood, November 15, 2002; 100(10): 3698 - 3702.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.