| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1-Producing Immunoregulatory CD8+ T Cells1
Departments of
*
Microbiology and Immunology,
Medicine, and
Pharmacy, University of North Carolina, Chapel Hill NC 27599
HIV-infected individuals may progressively lose both HIV-specific
and unrelated CTL responses despite the high number of circulating
CD8+ T cells. In this study, we report that 
25% of
HIV+ donors produced TGF-
1 in response to
stimulation with HIV proteins or peptides. The production of
TGF-1 was sufficient to significantly reduce the IFN-
response of CD8+ cells to both HIV and vaccinia virus
proteins. Ab to TGF- reversed the suppression. We found the source
of the TGF-1 to be predominantly CD8+
cells. Different peptide pools stimulated TGF-1 and
IFN- in the same individual. The TGF-1 secreting
cells have distinct peptide specificity from the IFN- producing
cells. This represents an important mechanism by which an HIV-specific
response can nonspecifically suppress both HIV-specific and unrelated
immune responses.
This article has been cited by other articles:
|
|
 |
|
  E. Billerbeck, N. Nakamoto, B. Seigel, H. E. Blum, K.-M. Chang, and R. Thimme Determinants of in vitro expansion of different human virus-specific FoxP3+ regulatory CD8+ T cells in chronic hepatitis C virus infection J. Gen. Virol., July 1, 2009; 90(7): 1692 - 1701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Elrefaei, C. A. R. Baker, N. G. Jones, D. R. Bangsberg, and H. Cao Presence of Suppressor HIV-Specific CD8+ T Cells Is Associated with Increased PD-1 Expression on Effector CD8+ T Cells J. Immunol., June 1, 2008; 180(11): 7757 - 7763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jin, Y. Kang, L. Zhao, C. Xiao, Y. Hu, R. She, Y. Yu, X. Du, G. Zhao, T. Ng, et al. Induction of Adaptive T Regulatory Cells That Suppress the Allergic Response by Coimmunization of DNA and Protein Vaccines J. Immunol., April 15, 2008; 180(8): 5360 - 5372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ho, C. C. Kurtz, M. Naganuma, P. B. Ernst, F. Cominelli, and J. Rivera-Nieves A CD8+/CD103high T Cell Subset Regulates TNF-Mediated Chronic Murine Ileitis J. Immunol., February 15, 2008; 180(4): 2573 - 2580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Karlsson, B. Malleret, P. Brochard, B. Delache, J. Calvo, R. Le Grand, and B. Vaslin FoxP3+ CD25+ CD8+ T-Cell Induction during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques Correlates with Low CD4+ T-Cell Activation and High Viral Load J. Virol., December 15, 2007; 81(24): 13444 - 13455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Derks, E. Jankowska-Gan, Q. Xu, and W. J. Burlingham Dendritic Cell Type Determines the Mechanism of Bystander Suppression by Adaptive T Regulatory Cells Specific for the Minor Antigen HA-1 J. Immunol., September 15, 2007; 179(6): 3443 - 3451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Xu, J. Lee, E. Jankowska-Gan, J. Schultz, D. A. Roennburg, L. D. Haynes, S. Kusaka, H. W. Sollinger, S. J. Knechtle, A. M. VanBuskirk, et al. Human CD4+CD25low Adaptive T Regulatory Cells Suppress Delayed-Type Hypersensitivity during Transplant Tolerance J. Immunol., March 15, 2007; 178(6): 3983 - 3995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Skinner, M. R. Pilione, H. Shen, E. T. Harvill, and M. H. Yuk Bordetella Type III Secretion Modulates Dendritic Cell Migration Resulting in Immunosuppression and Bacterial Persistence J. Immunol., October 1, 2005; 175(7): 4647 - 4652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lindesmith, C. Moe, J. LePendu, J. A. Frelinger, J. Treanor, and R. S. Baric Cellular and Humoral Immunity following Snow Mountain Virus Challenge J. Virol., March 1, 2005; 79(5): 2900 - 2909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Choudhary, N. R. Choudhary, K. C. Kimbrell, J. Colasanti, A. Ziogas, D. Kwa, H. Schuitemaker, and D. Camerini R5 Human Immunodeficiency Virus Type 1 Infection of Fetal Thymic Organ Culture Induces Cytokine and CCR5 Expression J. Virol., January 1, 2005; 79(1): 458 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Weiss, V. Donkova-Petrini, L. Caccavelli, M. Balbo, C. Carbonneil, and Y. Levy Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients Blood, November 15, 2004; 104(10): 3249 - 3256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. He, R. J. Messer, S. Sakaguchi, G. Yang, S. J. Robertson, and K. J. Hasenkrug Reduction of Retrovirus-Induced Immunosuppression by In Vivo Modulation of T Cells during Acute Infection J. Virol., November 1, 2004; 78(21): 11641 - 11647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. T. Rouse and S. Suvas Regulatory Cells and Infectious Agents: Detentes Cordiale and Contraire J. Immunol., August 15, 2004; 173(4): 2211 - 2215. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Martins, C. E. Tadokoro, R. B. Silva, J. S. Silva, and L. V. Rizzo CTLA-4 Blockage Increases Resistance to Infection with the Intracellular Protozoan Trypanosoma cruzi J. Immunol., April 15, 2004; 172(8): 4893 - 4901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cai, J. Lee, E. Jankowska-Gan, R. Derks, J. Pool, T. Mutis, E. Goulmy, and W. J. Burlingham Minor H Antigen HA-1-specific Regulator and Effector CD8+ T Cells, and HA-1 Microchimerism, in Allograft Tolerance J. Exp. Med., April 5, 2004; 199(7): 1017 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pal and L. M. Schnapp HIV-Infected Lymphocytes Regulate Fibronectin Synthesis by TGF{beta}1 Secretion J. Immunol., March 1, 2004; 172(5): 3189 - 3195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cosmi, F. Liotta, E. Lazzeri, M. Francalanci, R. Angeli, B. Mazzinghi, V. Santarlasci, R. Manetti, V. Vanini, P. Romagnani, et al. Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes Blood, December 1, 2003; 102(12): 4107 - 4114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. Omer, J. B. de Souza, and E. M. Riley Differential Induction of TGF-{beta} Regulates Proinflammatory Cytokine Production and Determines the Outcome of Lethal and Nonlethal Plasmodium yoelii Infections J. Immunol., November 15, 2003; 171(10): 5430 - 5436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. L. Tarakanova and W. S. M. Wold Transforming Growth Factor {beta}1 Receptor II Is Downregulated by E1A in Adenovirus-Infected Cells J. Virol., September 1, 2003; 77(17): 9324 - 9336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Maris, J. D. Miller, J. D. Altman, and J. Jacob A Transgenic Mouse Model Genetically Tags All Activated CD8 T Cells J. Immunol., September 1, 2003; 171(5): 2393 - 2401. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Buseyne, D. Scott-Algara, F. Porrot, B. Corre, N. Bellal, M. Burgard, C. Rouzioux, S. Blanche, and Y. Riviere Frequencies of Ex Vivo-Activated Human Immunodeficiency Virus Type 1-Specific Gamma-Interferon-Producing CD8+ T Cells in Infected Children Correlate Positively with Plasma Viral Load J. Virol., November 13, 2002; 76(24): 12414 - 12422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Sauri, J. A. Frelinger, M. L. Garba, R. B. Belshe, and S. E. Frey Responses to Smallpox Vaccine N. Engl. J. Med., August 29, 2002; 347(9): 689 - 690. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
