| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of
*
Dermatology and
Pathology, University Hospital of Zürich, Zürich, Switzerland; and
Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI 48109
The first step of leukocyte extravasation, leukocyte rolling, is
mediated by E-, P-, and L-selectins. Mice deficient for
-1,3-fucosyltransferase VII (FucTVII)-/- are
characterized by deficiency of E-, P-, and L-selectin ligand activity.
This model system was used to evaluate the role of the interactions of
selectins with their ligands in T and B cell responses. In the present
study, FucTVII-/- mice showed reduced CD4+ T
cell-mediated contact hypersensitivity reactions of the ears to FITC as
well as reduced CD8+ T cell-mediated delayed-type
hypersensitivity reactions of the footpads against lymphocytic
choriomeningitis virus infection. As Langerhans cell migration to local
lymph nodes as well as CD4+ and CD8+ T cell
induction were found to be normal, the afferent arm of these reactions
was not impaired. The reduced inflammatory reactions of the skin were
due to inefficient lymphocyte extravasation into the skin. In contrast,
extravasation of CD4+ and CD8+ T cells into
visceral organs, such as the ovaries or the brain, was not impaired in
FucTVII-/- mice. Elimination of vaccinia virus and of
lymphocytic choriomeningitis virus from ovaries and brain, as well as
elimination of tumor cells from several visceral organs was normal.
Thus, interactions of selectins with their ligands are important for
lymphocyte homing into the skin, but not for lymphocyte extravasation
into visceral organs.
This article has been cited by other articles:
|
|
 |
|
  C. Doebis, K. Siegmund, C. Loddenkemper, J. B. Lowe, A. C. Issekutz, A. Hamann, J. Huehn, and U. Syrbe Cellular Players and Role of Selectin Ligands in Leukocyte Recruitment in a T-Cell-Initiated Delayed-Type Hypersensitivity Reaction Am. J. Pathol., October 1, 2008; 173(4): 1067 - 1076. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Dudda, N. Perdue, E. Bachtanian, and D. J. Campbell Foxp3+ regulatory T cells maintain immune homeostasis in the skin J. Exp. Med., July 7, 2008; 205(7): 1559 - 1565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rana, S. N. Byrne, L. J. MacDonald, C. Y.-Y. Chan, and G. M. Halliday Ultraviolet B Suppresses Immunity by Inhibiting Effector and Memory T Cells Am. J. Pathol., April 1, 2008; 172(4): 993 - 1004. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ou, M. Zhang, L. Huang, R. A. Flavell, P. A. Koni, and D. Moskophidis Regulation of Immune Response and Inflammatory Reactions against Viral Infection by VCAM-1 J. Virol., March 15, 2008; 82(6): 2952 - 2965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jennrich, B. A. Ratsch, A. Hamann, and U. Syrbe Long-Term Commitment to Inflammation-Seeking Homing in CD4+ Effector Cells J. Immunol., June 15, 2007; 178(12): 8073 - 8080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Allahverdian, K. R. Wojcik, and D. R. Dorscheid Airway epithelial wound repair: role of carbohydrate sialyl Lewisx Am J Physiol Lung Cell Mol Physiol, October 1, 2006; 291(4): L828 - L836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Biedermann, G. Lametschwandtner, K. Tangemann, J. Kund, S. Hinteregger, N. Carballido-Perrig, A. Rot, C. Schwarzler, and J. M. Carballido IL-12 Instructs Skin Homing of Human Th2 Cells J. Immunol., September 15, 2006; 177(6): 3763 - 3770. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. H. Cai, A. Alvarez, P. Alcaide, P. Duramad, Y.-C. Lim, P. Jarolim, J. B. Lowe, F. W. Luscinskas, and A. H. Lichtman Abrogation of Functional Selectin-Ligand Expression Reduces Migration of Pathogenic CD8+ T Cells into Heart. J. Immunol., June 1, 2006; 176(11): 6568 - 6575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Schreiber, S. Ehlers, S. Aly, A. Holscher, S. Hartmann, M. Lipp, J. B. Lowe, and C. Holscher Selectin Ligand-Independent Priming and Maintenance of T Cell Immunity during Airborne Tuberculosis J. Immunol., January 15, 2006; 176(2): 1131 - 1140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Schachter The search for glycan function: Fucosylation of the TGF-{beta}1 receptor is required for receptor activation PNAS, November 1, 2005; 102(44): 15721 - 15722. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Siegmund, M. Feuerer, C. Siewert, S. Ghani, U. Haubold, A. Dankof, V. Krenn, M. P. Schon, A. Scheffold, J. B. Lowe, et al. Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo Blood, November 1, 2005; 106(9): 3097 - 3104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Masopust, V. Vezys, E. J. Usherwood, L. S. Cauley, S. Olson, A. L. Marzo, R. L. Ward, D. L. Woodland, and L. Lefrancois Activated Primary and Memory CD8 T Cells Migrate to Nonlymphoid Tissues Regardless of Site of Activation or Tissue of Origin J. Immunol., April 15, 2004; 172(8): 4875 - 4882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Hiraiwa, T. Yabuta, K. Yoritomi, M. Hiraiwa, Y. Tanaka, T. Suzuki, M. Yoshida, and R. Kannagi Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element Blood, May 1, 2003; 101(9): 3615 - 3621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Reinhardt, D. C. Bullard, C. T. Weaver, and M. K. Jenkins Preferential Accumulation of Antigen-specific Effector CD4 T Cells at an Antigen Injection Site Involves CD62E-dependent Migration but Not Local Proliferation J. Exp. Med., March 17, 2003; 197(6): 751 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Dimitroff, R. J. Bernacki, and R. Sackstein Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin Blood, January 15, 2003; 101(2): 602 - 610. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
