The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jansson, M.
Right arrow Articles by Cantor, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jansson, M.
Right arrow Articles by Cantor, H.
The Journal of Immunology, 2002, 168: 2096-2099.
Copyright © 2002 by The American Association of Immunologists

Cutting Edge

Cutting Edge: Attenuated Experimental Autoimmune Encephalomyelitis in Eta-1/Osteopontin-Deficient Mice1

Marianne Jansson, Vily Panoutsakopoulou, Jessica Baker, Ludger Klein and Harvey Cantor2

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, and Department of Pathology, Harvard Medical School, Boston, MA 02115

Recent studies indicate that early T lymphocyte activation 1 (Eta-1), also known as osteopontin, is a cytokine contributing to the development of Th1 immunity. In the present report, the role of Eta-1 in experimental autoimmune encephalomyelitis (EAE), a disease associated with Th1 immunity, was examined by analysis of disease progression in Eta-1-deficient (Eta-1-/-) mice. Although incidence and onset of peptide-induced EAE were found to be similar in Eta-1-/- and Eta-1+/+ mice, Eta-1-/- mice displayed significantly lower mean maximal clinical score and faster recovery without spontaneous relapses. Accordingly, decreased inflammatory infiltration and demyelination were observed in the spinal cords of Eta-1-/- mice. Furthermore, in comparison to Eta-1+/+, Eta-1-/- CD4+ T cells had reduced expression of IFN-{gamma} and TNF-{alpha} upon ex vivo restimulation. Taken together, these results suggest that Eta-1 may sustain autoimmune responses by assisting in maintenance of Th1 immunity during EAE.




This article has been cited by other articles:


Home page
 JEMHome page
Y. Yang, J. Weiner, Y. Liu, A. J. Smith, D. J. Huss, R. Winger, H. Peng, P. D. Cravens, M. K. Racke, and A. E. Lovett-Racke
T-bet is essential for encephalitogenicity of both Th1 and Th17 cells
J. Exp. Med., July 6, 2009; 206(7): 1549 - 1564.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Kanayama, D. Kurotaki, J. Morimoto, T. Asano, Y. Matsui, Y. Nakayama, Y. Saito, K. Ito, C. Kimura, N. Iwasaki, et al.
{alpha}9 Integrin and Its Ligands Constitute Critical Joint Microenvironments for Development of Autoimmune Arthritis
J. Immunol., June 15, 2009; 182(12): 8015 - 8025.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Murugaiyan, A. Mittal, and H. L. Weiner
Increased Osteopontin Expression in Dendritic Cells Amplifies IL-17 Production by CD4+ T Cells in Experimental Autoimmune Encephalomyelitis and in Multiple Sclerosis
J. Immunol., December 1, 2008; 181(11): 7480 - 7488.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. Steinman
A rush to judgment on Th17
J. Exp. Med., July 7, 2008; 205(7): 1517 - 1522.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Kon, M. Ikesue, C. Kimura, M. Aoki, Y. Nakayama, Y. Saito, D. Kurotaki, H. Diao, Y. Matsui, T. Segawa, et al.
Syndecan-4 protects against osteopontin-mediated acute hepatic injury by masking functional domains of osteopontin
J. Exp. Med., January 21, 2008; 205(1): 25 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Scatena, L. Liaw, and C. M. Giachelli
Osteopontin: A Multifunctional Molecule Regulating Chronic Inflammation and Vascular Disease
Arterioscler. Thromb. Vasc. Biol., November 1, 2007; 27(11): 2302 - 2309.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Kitamura, K. Iwabuchi, N. Kitaichi, S. Kon, H. Kitamei, K. Namba, K. Yoshida, D. T. Denhardt, S. R. Rittling, S. Ohno, et al.
Osteopontin Aggravates Experimental Autoimmune Uveoretinitis in Mice
J. Immunol., May 15, 2007; 178(10): 6567 - 6572.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Forte, B. G. Gold, G. Marracci, P. Chaudhary, E. Basso, D. Johnsen, X. Yu, J. Fowlkes, M. Rahder, K. Stem, et al.
Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis
PNAS, May 1, 2007; 104(18): 7558 - 7563.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Hashimoto, D. Sun, S. R. Rittling, D. T. Denhardt, and W. Young
Osteopontin-Deficient Mice Exhibit Less Inflammation, Greater Tissue Damage, and Impaired Locomotor Recovery from Spinal Cord Injury Compared with Wild-Type Controls
J. Neurosci., March 28, 2007; 27(13): 3603 - 3611.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. T. Hikita, B. P. Vistica, H. R. Jones, J. R. Keswani, M. M. Watson, V. R. Ericson, G. S. Ayoub, I. Gery, and D. O. Clegg
Osteopontin is proinflammatory in experimental autoimmune uveitis.
Invest. Ophthalmol. Vis. Sci., October 1, 2006; 47(10): 4435 - 4443.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Schroeter, P. Zickler, D. T. Denhardt, H.-P. Hartung, and S. Jander
Increased thalamic neurodegeneration following ischaemic cortical stroke in osteopontin-deficient mice
Brain, June 1, 2006; 129(6): 1426 - 1437.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
J. Sodek, A. P. Batista Da Silva, and R. Zohar
Osteopontin and Mucosal Protection
Journal of Dental Research, May 1, 2006; 85(5): 404 - 415.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. L. Shinohara, M. Jansson, E. S. Hwang, M. B. F. Werneck, L. H. Glimcher, and H. Cantor
T-bet-dependent expression of osteopontin contributes to T cell polarization
PNAS, November 22, 2005; 102(47): 17101 - 17106.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Abel, S. Freigang, M. F. Bachmann, U. Boschert, and M. Kopf
Osteopontin Is Not Required for the Development of Th1 Responses and Viral Immunity
J. Immunol., November 1, 2005; 175(9): 6006 - 6013.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. C. Renkl, J. Wussler, T. Ahrens, K. Thoma, S. Kon, T. Uede, S. F. Martin, J. C. Simon, and J. M. Weiss
Osteopontin functionally activates dendritic cells and induces their differentiation toward a Th1-polarizing phenotype
Blood, August 1, 2005; 106(3): 946 - 955.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Hayer, G. Steiner, B. Gortz, E. Reiter, M. Tohidast-Akrad, M. Amling, O. Hoffmann, K. Redlich, J. Zwerina, K. Skriner, et al.
CD44 is a determinant of inflammatory bone loss
J. Exp. Med., March 21, 2005; 201(6): 903 - 914.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
F. Giacopelli, R. Marciano, A. Pistorio, P. Catarsi, S. Canini, G. Karsenty, and R. Ravazzolo
Polymorphisms in the osteopontin promoter affect its transcriptional activity
Physiol Genomics, December 15, 2004; 20(1): 87 - 96.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Sahai, P. Malladi, X. Pan, R. Paul, H. Melin-Aldana, R. M. Green, and P. F. Whitington
Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: role of short-form leptin receptors and osteopontin
Am J Physiol Gastrointest Liver Physiol, November 1, 2004; 287(5): G1035 - G1043.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
W.-K. Suh, S. X. Wang, A. H. Jheon, L. Moreno, S. K. Yoshinaga, B. Ganss, J. Sodek, M. D. Grynpas, and T. W. Mak
The immune regulatory protein B7-H3 promotes osteoblast differentiation and bone mineralization
PNAS, August 31, 2004; 101(35): 12969 - 12973.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Iwata, N. Awaya, L. Graf, C. Kahl, and B. Torok-Storb
Human marrow stromal cells activate monocytes to secrete osteopontin, which down-regulates Notch1 gene expression in CD34+ cells
Blood, June 15, 2004; 103(12): 4496 - 4502.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
J. Morimoto, M. Inobe, C. Kimura, S. Kon, H. Diao, M. Aoki, T. Miyazaki, D. T. Denhardt, S. Rittling, and T. Uede
Osteopontin affects the persistence of {beta}-glucan-induced hepatic granuloma formation and tissue injury through two distinct mechanisms
Int. Immunol., March 1, 2004; 16(3): 477 - 488.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Chiocchetti, M. Indelicato, T. Bensi, R. Mesturini, M. Giordano, S. Sametti, L. Castelli, F. Bottarel, M. C. Mazzarino, L. Garbarini, et al.
High levels of osteopontin associated with polymorphisms in its gene are a risk factor for development of autoimmunity/lymphoproliferation
Blood, February 15, 2004; 103(4): 1376 - 1382.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
G. A. Johnson, R. C. Burghardt, F. W. Bazer, and T. E. Spencer
Osteopontin: Roles in Implantation and Placentation
Biol Reprod, November 1, 2003; 69(5): 1458 - 1471.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
L. Steinman
Optic Neuritis, A New Variant of Experimental Encephalomyelitis, A Durable Model for All Seasons, Now In Its Seventieth Year
J. Exp. Med., May 5, 2003; 197(9): 1065 - 1071.
[Full Text] [PDF]

Home page
 ScienceHome page
T. Blom, A. Franzen, D. Heinegard, and R. Holmdahl
Comment on "The Influence of the Proinflammatory Cytokine, Osteopontin, on Autoimmune Demyelinating Disease"
Science, March 21, 2003; 299(5614): 1845a - 1845a.
[Full Text] [PDF]

Home page
 ScienceHome page
L. Steinman, S. Youssef, N. Van Venrooij, D. Chabas, S. E. Baranzini, S. Rittling, D. Denhardt, R. A. Sobel, C. Lock, R. Pedotti, et al.
Response to Comment on "The Influence of the Proinflammatory Cytokine, Osteopontin, on Autoimmune Demyelinating Disease"
Science, March 21, 2003; 299(5614): 1845b - 1845b.
[Full Text] [PDF]

Home page
 JEMHome page
O. Aktas, S. Waiczies, A. Smorodchenko, J. Dorr, B. Seeger, T. Prozorovski, S. Sallach, M. Endres, S. Brocke, R. Nitsch, et al.
Treatment of Relapsing Paralysis in Experimental Encephalomyelitis by Targeting Th1 Cells through Atorvastatin
J. Exp. Med., March 17, 2003; 197(6): 725 - 733.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.