| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Center d’Immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale/Centre National de la Recherche Scientifique/Université de la Méditérranée, Parc Scientifique de Luminy, Marseille, France
The mechanisms that regulate CD4+ T cells responses in
vivo are still poorly understood. We show here that initial Ag
stimulation induces in CD4+ T cells a program of
proliferation that can develop, for at least seven cycles of division,
in the absence of subsequent Ag or cytokine requirement. Thereafter,
proliferation stops but can be reinitiated by novel Ag stimulation.
This initial Ag stimulation does not however suffice to induce the
differentiation of naive CD4+ T cells into effector Th1
cells which requires multiple contacts with Ag-loaded APC. Thus,
recurrent exposure to both Ag and polarizing cytokines appears to be
essential for the differentiation of IFN-
-producing cells. Ag and
cytokine availability therefore greatly limits the differentiation, but
not the initial proliferation, of CD4+ T cells into
IFN--producing cells.
This article has been cited by other articles:
|
|
 |
|
  A. Griffin, D. Baraho-Hassan, and S. J. McSorley Successful Treatment of Bacterial Infection Hinders Development of Acquired Immunity J. Immunol., July 15, 2009; 183(2): 1263 - 1270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Leung-Theung-Long, I. Mondor, M. Guiraud, C. Lamare, V. Nageleekar, P.-E. Paulet, M. Rincon, and S. Guerder Impaired NFAT Transcriptional Activity in Antigen-Stimulated CD8 T Cells Linked to Defective Phosphorylation of NFAT Transactivation Domain J. Immunol., June 1, 2009; 182(11): 6807 - 6814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jusforgues-Saklani, M. Uhl, N. Blachere, F. Lemaitre, O. Lantz, P. Bousso, D. Braun, J. J. Moon, and M. L. Albert Antigen Persistence Is Required for Dendritic Cell Licensing and CD8+ T Cell Cross-Priming J. Immunol., September 1, 2008; 181(5): 3067 - 3076. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Turner, E. D. Hawkins, and P. D. Hodgkin Quantitative Regulation of B Cell Division Destiny by Signal Strength J. Immunol., July 1, 2008; 181(1): 374 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Shaw and M. N. Starnbach Both CD4+ and CD8+ T Cells Respond to Antigens Fused to Anthrax Lethal Toxin Infect. Immun., June 1, 2008; 76(6): 2603 - 2611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Wissinger, W. W. Stevens, S. M. Varga, and T. J. Braciale Proliferative Expansion and Acquisition of Effector Activity by Memory CD4+ T Cells in the Lungs following Pulmonary Virus Infection J. Immunol., March 1, 2008; 180(5): 2957 - 2966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. J. Singh, M. Cox, and R. H. Schwartz TLR Ligands Differentially Modulate T Cell Responses to Acute and Chronic Antigen Presentation J. Immunol., December 15, 2007; 179(12): 7999 - 8008. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Blair and L. Lefrancois Increased competition for antigen during priming negatively impacts the generation of memory CD4 T cells PNAS, September 18, 2007; 104(38): 15045 - 15050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Mueller, M. S. Thomas, B. J. Burbach, E. J. Peterson, and Y. Shimizu Adhesion and Degranulation-Promoting Adapter Protein (ADAP) Positively Regulates T Cell Sensitivity to Antigen and T Cell Survival J. Immunol., September 15, 2007; 179(6): 3559 - 3569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. R. Moulton, N. D. Bushar, D. B. Leeser, D. S. Patke, and D. L. Farber Divergent Generation of Heterogeneous Memory CD4 T Cells J. Immunol., July 15, 2006; 177(2): 869 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Lazarski, F. A. Chaves, and A. J. Sant The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability J. Exp. Med., May 15, 2006; 203(5): 1319 - 1328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Verdeil, D. Puthier, C. Nguyen, A.-M. Schmitt-Verhulst, and N. Auphan-Anezin STAT5-mediated signals sustain a TCR-initiated gene expression program toward differentiation of CD8 T cell effectors. J. Immunol., April 15, 2006; 176(8): 4834 - 4842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Colombetti, V. Basso, D. L. Mueller, and A. Mondino Prolonged TCR/CD28 Engagement Drives IL-2-Independent T Cell Clonal Expansion through Signaling Mediated by the Mammalian Target of Rapamycin. J. Immunol., March 1, 2006; 176(5): 2730 - 2738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Whitmire, N. Benning, and J. L. Whitton Precursor Frequency, Nonlinear Proliferation, and Functional Maturation of Virus-Specific CD4+ T Cells. J. Immunol., March 1, 2006; 176(5): 3028 - 3036. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Foulds and H. Shen Clonal Competition Inhibits the Proliferation and Differentiation of Adoptively Transferred TCR Transgenic CD4 T Cells in Response to Infection. J. Immunol., March 1, 2006; 176(5): 3037 - 3043. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cassataro, S. M. Estein, K. A. Pasquevich, C. A. Velikovsky, S. de la Barrera, R. Bowden, C. A. Fossati, and G. H. Giambartolomei Vaccination with the Recombinant Brucella Outer Membrane Protein 31 or a Derived 27-Amino-Acid Synthetic Peptide Elicits a CD4+ T Helper 1 Response That Protects against Brucella melitensis Infection Infect. Immun., December 1, 2005; 73(12): 8079 - 8088. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Celli, Z. Garcia, and P. Bousso CD4 T cells integrate signals delivered during successive DC encounters in vivo J. Exp. Med., November 7, 2005; 202(9): 1271 - 1278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Ko, S.-Y. Ko, Y.-J. Kim, E.-G. Lee, S.-N. Cho, and C.-Y. Kang Optimization of Codon Usage Enhances the Immunogenicity of a DNA Vaccine Encoding Mycobacterial Antigen Ag85B Infect. Immun., September 1, 2005; 73(9): 5666 - 5674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Obst, H.-M. van Santen, D. Mathis, and C. Benoist Antigen persistence is required throughout the expansion phase of a CD4+ T cell response J. Exp. Med., May 16, 2005; 201(10): 1555 - 1565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inobe and R. H. Schwartz CTLA-4 Engagement Acts as a Brake on CD4+ T Cell Proliferation and Cytokine Production but Is Not Required for Tuning T Cell Reactivity in Adaptive Tolerance J. Immunol., December 15, 2004; 173(12): 7239 - 7248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Williams and M. J. Bevan Shortening the Infectious Period Does Not Alter Expansion of CD8 T Cells but Diminishes Their Capacity to Differentiate into Memory Cells J. Immunol., December 1, 2004; 173(11): 6694 - 6702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Zand, B. J. Briggs, A. Bose, and T. Vo Discrete Event Modeling of CD4+ Memory T Cell Generation J. Immunol., September 15, 2004; 173(6): 3763 - 3772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Matsuoka, N Inoue, T Sato, S Okamoto, T Hisamatsu, Y Kishi, A Sakuraba, O Hitotsumatsu, H Ogata, K Koganei, et al. T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease Gut, September 1, 2004; 53(9): 1303 - 1308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Boissonnas, C. Combadiere, E. Lavergne, M. Maho, C. Blanc, P. Debre, and B. Combadiere Antigen Distribution Drives Programmed Antitumor CD8 Cell Migration and Determines Its Efficiency J. Immunol., July 1, 2004; 173(1): 222 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Wurtz, M. Bajenoff, and S. Guerder IL-4-mediated inhibition of IFN-{gamma} production by CD4+ T cells proceeds by several developmentally regulated mechanisms Int. Immunol., March 1, 2004; 16(3): 501 - 508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bajenoff and S. Guerder Homing to Nonlymphoid Tissues Is Not Necessary for Effector Th1 Cell Differentiation J. Immunol., December 15, 2003; 171(12): 6355 - 6362. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. De Boer, D. Homann, and A. S. Perelson Different Dynamics of CD4+ and CD8+ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection J. Immunol., October 15, 2003; 171(8): 3928 - 3935. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bajenoff, S. Granjeaud, and S. Guerder The Strategy of T Cell Antigen-presenting Cell Encounter in Antigen-draining Lymph Nodes Revealed by Imaging of Initial T Cell Activation J. Exp. Med., September 2, 2003; 198(5): 715 - 724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Auphan-Anezin, G. Verdeil, and A.-M. Schmitt-Verhulst Distinct Thresholds for CD8 T Cell Activation Lead to Functional Heterogeneity: CD8 T Cell Priming Can Occur Independently of Cell Division J. Immunol., March 1, 2003; 170(5): 2442 - 2448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Rush, T. Mitchell, and P. Garside Efficient Priming of CD4+ and CD8+ T Cells by DNA Vaccination Depends on Appropriate Targeting of Sufficient Levels of Immunologically Relevant Antigen to Appropriate Processing Pathways J. Immunol., November 1, 2002; 169(9): 4951 - 4960. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
