The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Robert, J.
Right arrow Articles by Cohen, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Robert, J.
Right arrow Articles by Cohen, N.
The Journal of Immunology, 2002, 168: 1697-1703.
Copyright © 2002 by The American Association of Immunologists

Minor Histocompatibility Antigen-Specific MHC-Restricted CD8 T Cell Responses Elicited by Heat Shock Proteins1

Jacques Robert2, Jennifer Gantress, Laura Rau, Alisa Bell and Nicholas Cohen

Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642

In mammals, the heat shock proteins (HSP) gp96 and hsp70 elicit potent specific MHC class I-restricted CD8+ T cell (CTL) response to exogenous peptides they chaperone. We show in this study that in the adult frog Xenopus, a species whose common ancestors with mammals date back 300 million years, both hsp70 and gp96 generate an adaptive specific cellular immune response against chaperoned minor histocompatibility antigenic peptides that effects an accelerated rejection of minor histocompatibility-locus disparate skin grafts in vivo and an MHC-specific CD8+ cytotoxic T cell response in vitro. In naturally class I-deficient but immunocompetent Xenopus larvae, gp96 also generates an antitumor immune response that is independent of chaperoned peptides (i.e., gp96 purified from normal tissue also generates a significant antitumor response); this suggests a prominent contribution of an innate type of response in the absence of MHC class I Ags.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
J. Robert, T. Ramanayake, G. D. Maniero, H. Morales, and A. S. Chida
Phylogenetic Conservation of Glycoprotein 96 Ability to Interact with CD91 and Facilitate Antigen Cross-Presentation
J. Immunol., March 1, 2008; 180(5): 3176 - 3182.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
H. D. Morales and J. Robert
Characterization of Primary and Memory CD8 T-Cell Responses against Ranavirus (FV3) in Xenopus laevis
J. Virol., March 1, 2007; 81(5): 2240 - 2248.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
U. K. Rapp and S. H. Kaufmann
DNA vaccination with gp96-peptide fusion proteins induces protection against an intracellular bacterial pathogen
Int. Immunol., April 1, 2004; 16(4): 597 - 605.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Fleischer, B. Schmidt, W. Kastenmuller, D. H. Busch, I. Drexler, G. Sutter, M. Heike, C. Peschel, and H. Bernhard
Melanoma-Reactive Class I-Restricted Cytotoxic T Cell Clones Are Stimulated by Dendritic Cells Loaded with Synthetic Peptides, but Fail to Respond to Dendritic Cells Pulsed with Melanoma-Derived Heat Shock Proteins In Vitro
J. Immunol., January 1, 2004; 172(1): 162 - 169.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
J. C. Baker-LePain, M. Sarzotti, T. A. Fields, C.-Y. Li, and C. V. Nicchitta
GRP94 (gp96) and GRP94 N-Terminal Geldanamycin Binding Domain Elicit Tissue Nonrestricted Tumor Suppression
J. Exp. Med., December 2, 2002; 196(11): 1447 - 1459.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.