HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Le Campion, A. Articles by Pénit, C. Search for Related Content PubMed PubMed Citation Articles by Le Campion, A. Articles by Pénit, C.

Quantitative and Qualitative Adjustment of Thymic T Cell Production by Clonal Expansion of Premigrant Thymocytes¹

Armelle Le Campion^2,*, Bruno Lucas^*, Nicole Dautigny^*, Sandrine Léaument, Florence Vasseur^* and Claude Pénit^*

^* Institut National de la Santé et de la Recherche Médicale Unité 345 and Laboratoire d’Expérimentation Animale et de Transgénèse, Institut Necker, Paris, France

In normal mice, single-positive thymocytes proliferate before being exported into the peripheral T cell pool. We measured the in vivo proliferation rates of mature thymocytes in several TCR transgenic mice. Different monoclonal TCR transgenic single-positive thymocytes proliferated at different rates in a given MHC context. Conversely, mature thymocytes expressing a given TCR, generated in mice of different MHC haplotypes, also showed different rates of proliferation. In p59^fyn-deficient mice, the proliferation rate of mature thymocytes was diminished. Thus, premigrant thymocyte expansion is TCR mediated and depends on TCR affinity for self peptide/MHC ligands. In addition, we show that mature thymocyte expansion is clonotypic, increases the daily thymic T cell output, and modifies the TCR repertoire of newly produced T cells.

This article has been cited by other articles:

				V. Thomas-Vaslin, H. K. Altes, R. J. de Boer, and D. Klatzmann Comprehensive Assessment and Mathematical Modeling of T Cell Population Dynamics and Homeostasis J. Immunol., February 15, 2008; 180(4): 2240 - 2250. [Abstract] [Full Text] [PDF]

				A. L. Furmanski, C. Ferreira, I. Bartok, S. Dimakou, J. Rice, F. K. Stevenson, M. M. Millrain, E. Simpson, and J. Dyson Public T Cell Receptor -Chains Are Not Advantaged during Positive Selection J. Immunol., January 15, 2008; 180(2): 1029 - 1039. [Abstract] [Full Text] [PDF]

				T. M. McCaughtry, M. S. Wilken, and K. A. Hogquist Thymic emigration revisited J. Exp. Med., October 29, 2007; 204(11): 2513 - 2520. [Abstract] [Full Text] [PDF]

				A. P. Uldrich, S. P. Berzins, M. A. Malin, P. Bouillet, A. Strasser, M. J. Smyth, R. L. Boyd, and D. I. Godfrey Antigen challenge inhibits thymic emigration. J. Immunol., April 15, 2006; 176(8): 4553 - 4561. [Abstract] [Full Text] [PDF]

				D. Penkov, P. Di Rosa, L. Fernandez Diaz, V. Basso, E. Ferretti, F. Grassi, A. Mondino, and F. Blasi Involvement of Prep1 in the {alpha}{beta} T-Cell Receptor T-Lymphocytic Potential of Hematopoietic Precursors Mol. Cell. Biol., December 15, 2005; 25(24): 10768 - 10781. [Abstract] [Full Text] [PDF]

				F. J. Schnell and G. J. Kersh Control of Recent Thymic Emigrant Survival by Positive Selection Signals and Early Growth Response Gene 1 J. Immunol., August 15, 2005; 175(4): 2270 - 2277. [Abstract] [Full Text] [PDF]

				Z. Xing, E. M. Conway, C. Kang, and A. Winoto Essential Role of Survivin, an Inhibitor of Apoptosis Protein, in T Cell Development, Maturation, and Homeostasis J. Exp. Med., January 5, 2004; 199(1): 69 - 80. [Abstract] [Full Text] [PDF]

				B. Martin, C. Bourgeois, N. Dautigny, and B. Lucas On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells PNAS, May 13, 2003; 100(10): 6021 - 6026. [Abstract] [Full Text] [PDF]