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*
Department of Immunology and
Experimental Animal Center, The Weizmann Institute of Science, Rehovot, Israel;
Sourasky Medical Center, Tel-Aviv, Israel; and
Section of Immunobiology, Howard Hughes Medical Institute, Yale School of Medicine, New Haven, CT 06510
MHC class II molecules associate with the invariant chain (Ii)
molecule during biosynthesis. Ii facilitates the folding of class II
molecules, interferes with their peptide association, and is involved
in MHC class II transport. In this study, we have investigated the in
vitro and in vivo immune response of Ii-deficient mice
(Ii-/-). Our results have demonstrated that
CD4+ T cells from Ii-/- mice proliferate
normally in vitro after in vivo immunization with protein Ags. However,
cytokine secretion profiles of Ag-primed CD4+ T cells from
Ii-/- mice differ from CD4+ T cells from
wild-type mice. Whereas cells from wild-type mice secrete IFN-
and
IL-4, cells from Ii-/- mice secrete mostly IFN-.
Moreover, Ii-/- mice exhibit a normal Th1 response in the
delayed-type hypersensitivity and trinitrobenzene sulfonic acid
colitis models; however, these mice lack an in vivo Th2 response, as
demonstrated in the asthma model. Therefore, we suggest that defective
Ag presentation in Ii-/- mice leads selectively to a Th1
effector response.
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