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Cutting Edge |
Dependent in Mice Infected with a Neurotropic Coronavirus1
Departments of Pediatrics and Microbiology, University of Iowa, Iowa City, IA 52242
Mice infected with the murine coronavirus, mouse hepatitis
virus, strain JHM (MHV) develop an immune-mediated demyelinating
encephalomyelitis. We showed previously that adoptive transfer of
MHV-immune splenocytes depleted of either CD4 or CD8 T cells to
infected RAG1-/- recipients (mice
deficient in recombination activation gene 1) resulted in
demyelination. Herein we show that transfer of CD8 T cell-enriched
splenocytes from MHV-immune IFN-
-/- donors resulted in
a substantial decrease in demyelination (4.8% of the white matter of
the spinal cord compared with 26.3% in those receiving cells from
C57BL/6 donors). Similar numbers of lymphocytes were present in the CNS
of recipients of either C57BL/6 or IFN--/- CD8 T
cells, suggesting that IFN- was not crucial for lymphocyte entry
into the CNS. Rather, IFN- was critical for optimal activation or
migration of macrophages or microglia into the white matter in the
context of CD8 T cell-mediated demyelination.
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