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Cutting Edge |
,
*
Department of Medicine, Division of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118;
Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA 01665; and
Department of Pediatrics, Free University of Berlin, Berlin, Germany
The immunopotentiating activity of neisserial porins, the major
outer membrane protein of the pathogenic Neisseria, is
mediated by its ability to stimulate B cells and up-regulate the
surface expression of B7-2. This ability is dependent on MyD88 and
Toll-like receptor (TLR)2 expression, as demonstrated by a lack of a
response by B cells from MyD88 or TLR2 knockout mice to the porins.
Using previously described TLR2-dependent reporter constructs, these
results were confirmed and were shown to be due to induction of NF-
B
nuclear translocation. This is the first demonstration of known vaccine
adjuvant to stimulate immune cells via TLR2.
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E. Latz, J. Franko, D. T. Golenbock, and J. R. Schreiber Haemophilus influenzae Type b-Outer Membrane Protein Complex Glycoconjugate Vaccine Induces Cytokine Production by Engaging Human Toll-Like Receptor 2 (TLR2) and Requires the Presence of TLR2 for Optimal Immunogenicity J. Immunol., February 15, 2004; 172(4): 2431 - 2438. [Abstract] [Full Text] [PDF]
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P. Henneke and D. T. Golenbock Phagocytosis, Innate Immunity, and Host-Pathogen Specificity J. Exp. Med., January 5, 2004; 199(1): 1 - 4. [Full Text] [PDF]
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