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Cutting Edge |
Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
In this study, we compared the proliferation and differentiation of Ag-specific CD4 and CD8 T cells following Listeria infection. Our results show that CD4 T cells responding to infection divide a limited number of times, with progeny exhibiting proliferative arrest in early divisions. Even with increased infectious doses, CD4 T cells display this restricted proliferative pattern and are not driven to undergo extensive clonal expansion. This is in striking contrast to CD8 T cells, which undergo extensive proliferation in response to infection. These differences are also evident when CD4 and CD8 T cells receive uniform anti-CD3 stimulation in vitro. Together, these results suggest that CD4 and CD8 T cells are programmed to undergo limited and extensive proliferation, respectively, to suit their function as regulator and effector cells.
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E. L. Pearce, D. J. Shedlock, and H. Shen Functional Characterization of MHC Class II-Restricted CD8+CD4- and CD8-CD4- T Cell Responses to Infection in CD4-/- Mice J. Immunol., August 15, 2004; 173(4): 2494 - 2499. [Abstract] [Full Text] [PDF]
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A. L. Marzo, V. Vezys, K. D. Klonowski, S.-J. Lee, G. Muralimohan, M. Moore, D. F. Tough, and L. Lefrancois Fully Functional Memory CD8 T Cells in the Absence of CD4 T Cells J. Immunol., July 15, 2004; 173(2): 969 - 975. [Abstract] [Full Text] [PDF]
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K. Benlhassan-Chahour, C. Penit, V. Dioszeghy, F. Vasseur, G. Janvier, Y. Riviere, N. Dereuddre-Bosquet, D. Dormont, R. Le Grand, and B. Vaslin Kinetics of Lymphocyte Proliferation during Primary Immune Response in Macaques Infected with Pathogenic Simian Immunodeficiency Virus SIVmac251: Preliminary Report of the Effect of Early Antiviral Therapy J. Virol., December 1, 2003; 77(23): 12479 - 12493. [Abstract] [Full Text] [PDF]
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V. Jankovic, I. Messaoudi, and J. Nikolich-Zugich Phenotypic and functional T-cell aging in rhesus macaques (Macaca mulatta): differential behavior of CD4 and CD8 subsets Blood, November 1, 2003; 102(9): 3244 - 3251. [Abstract] [Full Text] [PDF]
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R. J. De Boer, D. Homann, and A. S. Perelson Different Dynamics of CD4+ and CD8+ T Cell Responses During and After Acute Lymphocytic Choriomeningitis Virus Infection J. Immunol., October 15, 2003; 171(8): 3928 - 3935. [Abstract] [Full Text] [PDF]
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J. Jiang, L. L. Lau, and H. Shen Selective Depletion of Nonspecific T Cells During the Early Stage of Immune Responses to Infection J. Immunol., October 15, 2003; 171(8): 4352 - 4358. [Abstract] [Full Text] [PDF]
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L. Lefrancois, A. Marzo, and K. Williams Sustained Response Initiation Is Required for T Cell Clonal Expansion But Not for Effector or Memory Development In Vivo J. Immunol., September 15, 2003; 171(6): 2832 - 2839. [Abstract] [Full Text] [PDF]
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R. E. Kohler, A. C. Caon, D. O. Willenborg, I. Clark-Lewis, and S. R. McColl A Role for Macrophage Inflammatory Protein-3{alpha}/CC Chemokine Ligand 20 in Immune Priming During T Cell-Mediated Inflammation of the Central Nervous System J. Immunol., June 15, 2003; 170(12): 6298 - 6306. [Abstract] [Full Text] [PDF]
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V. P. Badovinac, K. A. Nordyke Messingham, S. E. Hamilton, and J. T. Harty Regulation of CD8+ T Cells Undergoing Primary and Secondary Responses to Infection in the Same Host J. Immunol., May 15, 2003; 170(10): 4933 - 4942. [Abstract] [Full Text] [PDF]
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B. Adkins, T. Williamson, P. Guevara, and Y. Bu Murine Neonatal Lymphocytes Show Rapid Early Cell Cycle Entry and Cell Division J. Immunol., May 1, 2003; 170(9): 4548 - 4556. [Abstract] [Full Text] [PDF]
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 D. J. Shedlock and H. Shen Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory Science, April 11, 2003; 300(5617): 337 - 339. [Abstract] [Full Text] [PDF]
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H. Shen, J. K. Whitmire, X. Fan, D. J. Shedlock, S. M. Kaech, and R. Ahmed A Specific Role for B Cells in the Generation of CD8 T Cell Memory by Recombinant Listeria monocytogenes J. Immunol., February 1, 2003; 170(3): 1443 - 1451. [Abstract] [Full Text] [PDF]
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D. Voehringer, M. Koschella, and H. Pircher Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1) Blood, November 15, 2002; 100(10): 3698 - 3702. [Abstract] [Full Text] [PDF]
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C. Rush, T. Mitchell, and P. Garside Efficient Priming of CD4+ and CD8+ T Cells by DNA Vaccination Depends on Appropriate Targeting of Sufficient Levels of Immunologically Relevant Antigen to Appropriate Processing Pathways J. Immunol., November 1, 2002; 169(9): 4951 - 4960. [Abstract] [Full Text] [PDF]
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D. K. Smith, R. Dudani, J. A. Pedras-Vasconcelos, Y. Chapdelaine, H. van Faassen, and S. Sad Cross-Reactive Antigen Is Required to Prevent Erosion of Established T Cell Memory and Tumor Immunity: A Heterologous Bacterial Model of Attrition J. Immunol., August 1, 2002; 169(3): 1197 - 1206. [Abstract] [Full Text] [PDF]
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