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Cutting Edge |
(LT) and Retinoic Acid Receptor-Related Orphan Receptor-
, but the Organization of NALT Is LT Dependent1
*
Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717;
Trudeau Institute, Saranac Lake, NY 12983;
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine and Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016;
Department of Immunology, DNAX, Palo Alto, CA 94304; and
¶ Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
Peyer’s patch and nasal-associated lymphoid tissue (NALT) are
mucosal lymphoid tissues that appear similar in structure and function.
Surprisingly, we found that NALT, unlike Peyer’s patch, was formed
independently of lymphotoxin (LT)
. Furthermore, using mice deficient
in the retinoic acid receptor-related orphan receptor-
, we found
that NALT was formed in the absence of
CD4+CD3- cells, which are thought to be the
embryonic source of LT. However, we also found that NALT of
LT-/- animals was disorganized and lymphopenic,
suggesting that the organization and recruitment of lymphocytes within
NALT remained dependent on LT. Finally, we demonstrated that both
the structure and function of NALT were restored in
LT-/- animals upon reconstitution with normal bone
marrow. These results demonstrate that the organogenesis of NALT occurs
through unique mechanisms.
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