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9V
2+ T Cell Effectors in Immunocompromised Hosts and During Active Pulmonary Tuberculosis1
*
Laboratory of Clinical Pathology-Immunopathology, "Padiglione Del Vecchio," National Institute for Infectious Diseases, "Lazzaro Spallanzani," Istituto di Ricerca e Cura a Carattere Scientifico, Rome, Italy; and
Research Center, "San Pietro-Fatebenefratelli,"
Laboratory of Neuroimmunology, "Santa Lucia Foundation," Istituto di Ricerca e Cura a Carattere Scientifico, and
Department of Biology, University of Rome, "Tor Vergata," Rome, Italy
In humans, the circulating pool of mycobacteria-reactive
V
9V
2+ T cells is expanded with age and may contribute
to Mycobacterium tuberculosis immunosurveillance. We
observed that two subsets of V9V2+ T cells could be
identified on the basis of CD27 expression in immunocompetent adults,
showing that functionally differentiated T cells have lost CD27
expression. In contrast, the
CD27-CD45RA-V9V2+ T cell
subset of effector cells was absent in cord blood cells from healthy
newborns and lacking in the peripheral blood from HIV-infected
patients. Moreover, circulating V9V2+ T cell
effectors were significantly reduced in patients with acute pulmonary
tuberculosis, resulting in a reduced frequency of IFN--producing
cells after stimulation with nonpeptidic mycobacterial ligands. These
observations indicate that monitoring and boosting T cell
effectors could be clinically relevant both in immunocompromised hosts
and during active tuberculosis disease.
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