| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
9V
2+ T Cell Effectors in Immunocompromised Hosts and During Active Pulmonary Tuberculosis1
*
Laboratory of Clinical Pathology-Immunopathology, "Padiglione Del Vecchio," National Institute for Infectious Diseases, "Lazzaro Spallanzani," Istituto di Ricerca e Cura a Carattere Scientifico, Rome, Italy; and
Research Center, "San Pietro-Fatebenefratelli,"
Laboratory of Neuroimmunology, "Santa Lucia Foundation," Istituto di Ricerca e Cura a Carattere Scientifico, and
Department of Biology, University of Rome, "Tor Vergata," Rome, Italy
In humans, the circulating pool of mycobacteria-reactive
V
9V
2+ T cells is expanded with age and may contribute
to Mycobacterium tuberculosis immunosurveillance. We
observed that two subsets of V9V2+ T cells could be
identified on the basis of CD27 expression in immunocompetent adults,
showing that functionally differentiated T cells have lost CD27
expression. In contrast, the
CD27-CD45RA-V9V2+ T cell
subset of effector cells was absent in cord blood cells from healthy
newborns and lacking in the peripheral blood from HIV-infected
patients. Moreover, circulating V9V2+ T cell
effectors were significantly reduced in patients with acute pulmonary
tuberculosis, resulting in a reduced frequency of IFN--producing
cells after stimulation with nonpeptidic mycobacterial ligands. These
observations indicate that monitoring and boosting T cell
effectors could be clinically relevant both in immunocompromised hosts
and during active tuberculosis disease.
This article has been cited by other articles:
|
|
 |
|
  A. Bourgarit, G. Carcelain, A. Samri, C. Parizot, M. Lafaurie, S. Abgrall, V. Delcey, E. Vicaut, D. Sereni, B. Autran, et al. Tuberculosis-Associated Immune Restoration Syndrome in HIV-1-Infected Patients Involves Tuberculin-Specific CD4 Th1 Cells and KIR-Negative {gamma}{delta} T Cells J. Immunol., September 15, 2009; 183(6): 3915 - 3923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fenoglio, A. Poggi, S. Catellani, F. Battaglia, A. Ferrera, M. Setti, G. Murdaca, and M. R. Zocchi V{delta}1 T lymphocytes producing IFN-{gamma} and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans Blood, June 25, 2009; 113(26): 6611 - 6618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Pitard, D. Roumanes, X. Lafarge, L. Couzi, I. Garrigue, M.-E. Lafon, P. Merville, J.-F. Moreau, and J. Dechanet-Merville Long-term expansion of effector/memory V{delta}2- {gamma}{delta} T cells is a specific blood signature of CMV infection Blood, August 15, 2008; 112(4): 1317 - 1324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-S. Cummings, C. Cairo, C. Armstrong, C. E. Davis, and C. D. Pauza Impacts of HIV infection on V{gamma}2V{delta}2 T cell phenotype and function: a mechanism for reduced tumor immunity in AIDS J. Leukoc. Biol., August 1, 2008; 84(2): 371 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Kosub, G. Lehrman, J. M. Milush, D. Zhou, E. Chacko, A. Leone, S. Gordon, G. Silvestri, J. G. Else, P. Keiser, et al. Gamma/Delta T-Cell Functional Responses Differ after Pathogenic Human Immunodeficiency Virus and Nonpathogenic Simian Immunodeficiency Virus Infections J. Virol., February 1, 2008; 82(3): 1155 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Martino, R. Casetti, A. Sacchi, and F. Poccia Central Memory V{gamma}9V{delta}2 T Lymphocytes Primed and Expanded by Bacillus Calmette-Guerin-Infected Dendritic Cells Kill Mycobacterial-Infected Monocytes J. Immunol., September 1, 2007; 179(5): 3057 - 3064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yeboah-Manu, E. Peduzzi, E. Mensah-Quainoo, A. Asante-Poku, D. Ofori-Adjei, G. Pluschke, and C. A. Daubenberger Systemic suppression of interferon-{gamma} responses in Buruli ulcer patients resolves after surgical excision of the lesions caused by the extracellular pathogen Mycobacterium ulcerans J. Leukoc. Biol., June 1, 2006; 79(6): 1150 - 1156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sicard, S. Ingoure, B. Luciani, C. Serraz, J.-J. Fournie, M. Bonneville, J. Tiollier, and F. Romagne In Vivo Immunomanipulation of V{gamma}9V{delta}2 T Cells with a Synthetic Phosphoantigen in a Preclinical Nonhuman Primate Model J. Immunol., October 15, 2005; 175(8): 5471 - 5480. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Casetti, G. Perretta, A. Taglioni, M. Mattei, V. Colizzi, F. Dieli, G. D'Offizi, M. Malkovsky, and F. Poccia Drug-Induced Expansion and Differentiation of V{gamma}9V{delta}2 T Cells In Vivo: The Role of Exogenous IL-2 J. Immunol., August 1, 2005; 175(3): 1593 - 1598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Poupot, F. Pont, and J.-J. Fournie Profiling Blood Lymphocyte Interactions with Cancer Cells Uncovers the Innate Reactivity of Human {gamma}{delta} T Cells to Anaplastic Large Cell Lymphoma J. Immunol., February 1, 2005; 174(3): 1717 - 1722. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Eberl, R. Engel, S. Aberle, P. Fisch, H. Jomaa, and H. Pircher Human V{gamma}9/V{delta}2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1) J. Leukoc. Biol., January 1, 2005; 77(1): 67 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. F. Angelini, G. Borsellino, M. Poupot, A. Diamantini, R. Poupot, G. Bernardi, F. Poccia, J.-J. Fournie, and L. Battistini Fc{gamma}RIII discriminates between 2 subsets of V{gamma}9V{delta}2 effector cells with different responses and activation pathways Blood, September 15, 2004; 104(6): 1801 - 1807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Brandes, K. Willimann, A. B. Lang, K.-H. Nam, C. Jin, M. B. Brenner, C. T. Morita, and B. Moser Flexible migration program regulates {gamma}{delta} T-cell involvement in humoral immunity Blood, November 15, 2003; 102(10): 3693 - 3701. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Dieli, N. Gebbia, F. Poccia, N. Caccamo, C. Montesano, F. Fulfaro, C. Arcara, M. R. Valerio, S. Meraviglia, C. Di Sano, et al. Induction of {gamma}{delta} T-lymphocyte effector functions by bisphosphonate zoledronic acid in cancer patients in vivo Blood, September 15, 2003; 102(6): 2310 - 2311. [Full Text] [PDF]
|
|
|
|
 |
|
 F. Dieli, F. Poccia, M. Lipp, G. Sireci, N. Caccamo, C. Di Sano, and A. Salerno Differentiation of Effector/Memory V{delta}2 T Cells and Migratory Routes in Lymph Nodes or Inflammatory Sites J. Exp. Med., August 4, 2003; 198(3): 391 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Zhou, X. Lai, Y. Shen, P. Sehgal, L. Shen, M. Simon, L. Qiu, D. Huang, G. Z. Du, Q. Wang, et al. Inhibition of Adaptive V{gamma}2V{delta}2+ T-Cell Responses during Active Mycobacterial Coinfection of Simian Immunodeficiency Virus SIVmac-Infected Monkeys J. Virol., March 1, 2003; 77(5): 2998 - 3006. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Cipriani, H. Knowles, L. Chen, L. Battistini, and C. F. Brosnan Involvement of Classical and Novel Protein Kinase C Isoforms in the Response of Human V{gamma}9V{delta}2 T Cells to Phosphate Antigens J. Immunol., November 15, 2002; 169(10): 5761 - 5770. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
