The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schuh, J. M.
Right arrow Articles by Hogaboam, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schuh, J. M.
Right arrow Articles by Hogaboam, C. M.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Asthma
The Journal of Immunology, 2002, 168: 1447-1456.
Copyright © 2002 by The American Association of Immunologists

CXCR2 Is Necessary for the Development and Persistence of Chronic Fungal Asthma in Mice1

Jane M. Schuh, Kate Blease and Cory M. Hogaboam2

Department of Pathology University of Michigan Medical School, Ann Arbor, MI 48109

The role of CXCR during allergic airway and asthmatic diseases is yet to be fully characterized. Therefore, the present study addressed the role of CXCR2 during Aspergillus fumigatus-induced asthma. Mice deficient in CXCR2 (CXCR2-/-) and wild-type counterparts (CXCR2+/+) were sensitized to A. fumigatus Ags and challenged with A. fumigatus conidia, and the resulting allergic airway disease was monitored for up to 37 days. At days 3 and 7 after conidia, CXCR2-/- mice exhibited significantly greater methacholine-induced airway hyperreactivity than did CXCR2+/+ mice. In contrast, CXCR2-deficient mice exhibited significantly less airway hyperresponsiveness than the wild-type control groups at days 14 and 37 after conidia. At all times after conidia, whole lung levels of IL-4, IL-5, and eotaxin/CC chemokine ligand 11 were significantly lower in CXCR2-/- mice than in the wild-type controls. Eosinophil and T cell, but not neutrophil, recruitment into the airways of A. fumigatus-sensitized CXCR2-/- mice was significantly impaired compared with wild-type controls at all times after the conidia challenge. Whole lung levels of IFN-{gamma}, inflammatory protein-10/CXC ligand (CXCL) 10, and monokine induced by IFN-{gamma} (MIG)/CXCL9 were significantly increased in CXCR2-/- mice compared with CXCR2+/+ mice at various times after conidia. Interestingly, at day 3 after conidia, neutrophil recruitment and airway hyperresponsiveness in CXCR2-/- mice was mediated by inflammatory protein-10/CXCL10 and, to a lesser degree, MIG/CXCL9. Taken together, these data suggest that CXCR2 contributes to the persistence of asthmatic disease due to A. fumigatus.




This article has been cited by other articles:


Home page
 JEMHome page
K. A. Cavassani, M. Ishii, H. Wen, M. A. Schaller, P. M. Lincoln, N. W. Lukacs, C. M. Hogaboam, and S. L. Kunkel
TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events
J. Exp. Med., October 27, 2008; 205(11): 2609 - 2621.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
A. G. Therien, V. Bernier, S. Weicker, P. Tawa, J.-P. Falgueyret, M.-C. Mathieu, J. Honsberger, V. Pomerleau, A. Robichaud, R. Stocco, et al.
Adenovirus IL-13-Induced Airway Disease in Mice: A Corticosteroid-Resistant Model of Severe Asthma
Am. J. Respir. Cell Mol. Biol., July 1, 2008; 39(1): 26 - 35.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Hallgren, T. G. Jones, J. P. Abonia, W. Xing, A. Humbles, K. F. Austen, and M. F. Gurish
Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors
PNAS, December 18, 2007; 104(51): 20478 - 20483.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. R. Beaty, C. E. Rose Jr., and S.-s. J. Sung
Diverse and Potent Chemokine Production by Lung CD11bhigh Dendritic Cells in Homeostasis and in Allergic Lung Inflammation
J. Immunol., February 1, 2007; 178(3): 1882 - 1895.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. R. Bonnett, E. J. Cornish, A. G. Harmsen, and J. B. Burritt
Early Neutrophil Recruitment and Aggregation in the Murine Lung Inhibit Germination of Aspergillus fumigatus Conidia
Infect. Immun., December 1, 2006; 74(12): 6528 - 6539.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
D. W. Denning, B. R. O'Driscoll, C. M. Hogaboam, P. Bowyer, and R. M. Niven
The link between fungi and severe asthma: a summary of the evidence.
Eur. Respir. J., March 1, 2006; 27(3): 615 - 626.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. J. Park, M. T. Wiekowski, S. A. Lira, and B. Mehrad
Neutrophils Regulate Airway Responses in a Model of Fungal Allergic Airways Disease
J. Immunol., February 15, 2006; 176(4): 2538 - 2545.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
S. A. K. Harvey, E. G. Romanowski, K. A. Yates, and Y. J. Gordon
Adenovirus-Directed Ocular Innate Immunity: The Role of Conjunctival Defensin-like Chemokines (IP-10, I-TAC) and Phagocytic Human Defensin-{alpha}
Invest. Ophthalmol. Vis. Sci., October 1, 2005; 46(10): 3657 - 3665.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Arora, Y. Hernandez, J. R. Erb-Downward, R. A. McDonald, G. B. Toews, and G. B. Huffnagle
Role of IFN-{gamma} in Regulating T2 Immunity and the Development of Alternatively Activated Macrophages during Allergic Bronchopulmonary Mycosis
J. Immunol., May 15, 2005; 174(10): 6346 - 6356.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. Page, V. S. Hughes, K. K. Odoms, K. E. Dunsmore, and M. B. Hershenson
German Cockroach Proteases Regulate Interleukin-8 Expression via Nuclear Factor for Interleukin-6 in Human Bronchial Epithelial Cells
Am. J. Respir. Cell Mol. Biol., March 1, 2005; 32(3): 225 - 231.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. C. Noverr, R. M. Noggle, G. B. Toews, and G. B. Huffnagle
Role of Antibiotics and Fungal Microbiota in Driving Pulmonary Allergic Responses
Infect. Immun., September 1, 2004; 72(9): 4996 - 5003.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
C. M. Hogaboam, K. Takahashi, R. A. B. Ezekowitz, S. L. Kunkel, and J. M. Schuh
Mannose-binding lectin deficiency alters the development of fungal asthma: effects on airway response, inflammation, and cytokine profile
J. Leukoc. Biol., May 1, 2004; 75(5): 805 - 814.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. L. Ness, C. M. Hogaboam, R. M. Strieter, and S. L. Kunkel
Immunomodulatory Role of CXCR2 During Experimental Septic Peritonitis
J. Immunol., October 1, 2003; 171(7): 3775 - 3784.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. W. Lukacs, A. L. Miller, and C. M. Hogaboam
Chemokine Receptors in Asthma: Searching for the Correct Immune Targets
J. Immunol., July 1, 2003; 171(1): 11 - 15.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
A. L. Miller, R. M. Strieter, A. D. Gruber, S. B. Ho, and N. W. Lukacs
CXCR2 Regulates Respiratory Syncytial Virus-Induced Airway Hyperreactivity and Mucus Overproduction
J. Immunol., March 15, 2003; 170(6): 3348 - 3356.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
B. Mehrad, M. Wiekowski, B. E. Morrison, S.-C. Chen, E. C. Coronel, D. J. Manfra, and S. A. Lira
Transient Lung-Specific Expression of the Chemokine KC Improves Outcome in Invasive Aspergillosis
Am. J. Respir. Crit. Care Med., November 1, 2002; 166(9): 1263 - 1268.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.