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*
Unité de Biologie des Régulations Immunitaires,
Unité d’Histopathologie, and
Unité de Génétique Mycobactérienne, Institut Pasteur, Paris, France
In the present study, we investigated in vivo the infection and APC
functions of dendritic cells (DC) and macrophages (M
) after
administration of live mycobacteria to mice. Experiments were conducted
with Mycobacterium bovis bacillus Calmette-Guerin (BCG)
or a rBCG expressing a reporter Ag. Following infection of mice, DC and
M were purified and the presence of immunogenic peptide/MHC class II
complexes was detected ex vivo on sorted cells, as was the secretion of
IL-12 p40. We show in this study that DC is a host cell for
mycobacteria, and we provide an in vivo detailed picture of the role of
M and DC in the mobilization of immunity during the early stages of
a bacterial infection. Strikingly, BCG bacilli survive but remain
stable in number in the DC leukocyte subset during the first 2 wk of
infection. As Ag presentation by DC is rapidly lost, this suggests that
DC may represent a hidden reservoir for
mycobacteria.
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