| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
and TNF-
Mediated Up-Regulation During Inflammation1
*
Nutrition and Toxicology Research Institute Maastricht, Department of General Surgery, University of Maastricht, Maastricht, The Netherlands; and
Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
The reported requirement of functional Toll-like receptor (TLR)4
for resistance to Gram-negative pyelonephritis prompted us to localize
the expression of TLR2 and TLR4 mRNA in the kidney at the cellular
level by in situ hybridization. The majority of the constitutive TLR2
and TLR4 mRNA expression was found to be strategically located in the
renal epithelial cells. Assuming that the TLR mRNA expression is
representative of apical protein expression, this suggests that these
cells are able to detect and react with bacteria present in the lumen
of the tubules. To gain insight in the regulation of TLR expression
during inflammation, we used a model for renal inflammation. Renal
inflammation evoked by ischemia markedly enhanced synthesis of TLR2 and
TLR4 mRNA in the distal tubular epithelium, the thin limb of Henle’s
loop, and collecting ducts. The increased renal TLR4 mRNA expression
was associated with significant elevation of renal TLR4 protein
expression as evaluated by Western blotting. Using RT-PCR, the enhanced
TLR2 and TLR4 mRNA expression was shown to be completely dependent on
the action of IFN-
and TNF-
. These results indicate a potential
mechanism of increased immunosurveillance during inflammation at the
site in which ascending bacteria enter the kidney tissue, i.e., the
collecting ducts and the distal part of the
nephron.
This article has been cited by other articles:
|
|
 |
|
  A. C. Shirali and D. R. Goldstein Tracking the Toll of Kidney Disease J. Am. Soc. Nephrol., August 1, 2008; 19(8): 1444 - 1450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Y. Ghee, D. H. Han, H. K. Song, W. Y. Kim, S. H. Kim, H. E. Yoon, B. S. Choi, Y. S. Kim, J. Kim, and C. W. Yang The role of macrophage in the pathogenesis of chronic cyclosporine-induced nephropathy Nephrol. Dial. Transplant., July 12, 2008; (2008) gfn388v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Zhang, G. Ramesh, S. Uematsu, S. Akira, and W. B. Reeves TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity J. Am. Soc. Nephrol., May 1, 2008; 19(5): 923 - 932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Yao, I. Edirisinghe, S.-R. Yang, S. Rajendrasozhan, A. Kode, S. Caito, D. Adenuga, and I. Rahman Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice Am. J. Pathol., May 1, 2008; 172(5): 1222 - 1237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Banas, B. Banas, K. L. Hudkins, T. A. Wietecha, M. Iyoda, E. Bock, P. Hauser, J. W. Pippin, S. J. Shankland, K. D. Smith, et al. TLR4 Links Podocytes with the Innate Immune System to Mediate Glomerular Injury J. Am. Soc. Nephrol., April 1, 2008; 19(4): 704 - 713. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Zager, A. C. M. Johnson, M. Naito, and K. Bomsztyk Maleate nephrotoxicity: mechanisms of injury and correlates with ischemic/hypoxic tubular cell death Am J Physiol Renal Physiol, January 1, 2008; 294(1): F187 - F197. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tsung, J. R. Klune, X. Zhang, G. Jeyabalan, Z. Cao, X. Peng, D. B. Stolz, D. A. Geller, M. R. Rosengart, and T. R. Billiar HMGB1 release induced by liver ischemia involves Toll-like receptor 4 dependent reactive oxygen species production and calcium-mediated signaling J. Exp. Med., November 26, 2007; 204(12): 2913 - 2923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Andreani, G. Gatti, L. Simonella, V. Rivero, and M. Maccioni Activation of Toll-like Receptor 4 on Tumor Cells In vitro Inhibits Subsequent Tumor Growth In vivo Cancer Res., November 1, 2007; 67(21): 10519 - 10527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Uno, K. Kato, T. Atsumi, T. Suzuki, J. Yoshitake, H. Morita, S. Ohara, Y. Kotake, T. Shimosegawa, and T. Yoshimura Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells Am J Physiol Gastrointest Liver Physiol, November 1, 2007; 293(5): G1004 - G1012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Levy, K. P. Mollen, J. M. Prince, D. J. Kaczorowski, R. Vallabhaneni, S. Liu, K. J. Tracey, M. T. Lotze, D. J. Hackam, M. P. Fink, et al. Systemic inflammation and remote organ injury following trauma require HMGB1 Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1538 - R1544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-C. Yang, M.-C. Ma, C.-T. Chien, M.-S. Wu, W.-K. Sun, and C.-F. Chen Hypoxic preconditioning attenuates lipopolysaccharide-induced oxidative stress in rat kidneys J. Physiol., July 1, 2007; 582(1): 407 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Brown, H. R. Lock, T. G.A.M. Wolfs, W. A. Buurman, S. H. Sacks, and M. G. Robson Toll-Like Receptor 4 Ligation on Intrinsic Renal Cells Contributes to the Induction of Antibody-Mediated Glomerulonephritis via CXCL1 and CXCL2 J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1732 - 1739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Shigeoka, T. D. Holscher, A. J. King, F. W. Hall, W. B. Kiosses, P. S. Tobias, N. Mackman, and D. B. McKay TLR2 Is Constitutively Expressed within the Kidney and Participates in Ischemic Renal Injury through Both MyD88-Dependent and -Independent Pathways J. Immunol., May 15, 2007; 178(10): 6252 - 6258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Spiller, S. Dreher, G. Meng, A. Grabiec, W. Thomas, T. Hartung, K. Pfeffer, H. Hochrein, H. Brade, W. Bessler, et al. Cellular Recognition of Trimyristoylated Peptide or Enterobacterial Lipopolysaccharide via Both TLR2 and TLR4 J. Biol. Chem., May 4, 2007; 282(18): 13190 - 13198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. I. Maratheftis, E. Andreakos, H. M. Moutsopoulos, and M. Voulgarelis Toll-like Receptor-4 Is Up-Regulated in Hematopoietic Progenitor Cells and Contributes to Increased Apoptosis in Myelodysplastic Syndromes Clin. Cancer Res., February 15, 2007; 13(4): 1154 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tsung, N. Zheng, G. Jeyabalan, K. Izuishi, J. R. Klune, D. A. Geller, M. T. Lotze, L. Lu, and T. R. Billiar Increasing numbers of hepatic dendritic cells promote HMGB1-mediated ischemia-reperfusion injury J. Leukoc. Biol., January 1, 2007; 81(1): 119 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Zager, A. C. M. Johnson, S. Lund, and J. Randolph-Habecker Toll-like receptor (TLR4) shedding and depletion: acute proximal tubular cell responses to hypoxic and toxic injury Am J Physiol Renal Physiol, January 1, 2007; 292(1): F304 - F312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Chassin, J.-M. Goujon, S. Darche, L. du Merle, M. Bens, F. Cluzeaud, C. Werts, E. Ogier-Denis, C. Le Bouguenec, D. Buzoni-Gatel, et al. Renal Collecting Duct Epithelial Cells React to Pyelonephritis-Associated Escherichia coli by Activating Distinct TLR4-Dependent and -Independent Inflammatory Pathways J. Immunol., October 1, 2006; 177(7): 4773 - 4784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Pawar, P. S. Patole, M. Wornle, and H.-J. Anders Microbial nucleic acids pay a Toll in kidney disease Am J Physiol Renal Physiol, September 1, 2006; 291(3): F509 - F516. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Zager, A. C. M. Johnson, S. Lund, and S. Hanson Acute renal failure: determinants and characteristics of the injury-induced hyperinflammatory response Am J Physiol Renal Physiol, September 1, 2006; 291(3): F546 - F556. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Brown, H. R. Lock, S. H. Sacks, and M. G. Robson TLR2 Stimulation of Intrinsic Renal Cells in the Induction of Immune-Mediated Glomerulonephritis J. Immunol., August 1, 2006; 177(3): 1925 - 1931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. Brown, S. H. Sacks, and M. G. Robson Toll-Like Receptor 2 Agonists Exacerbate Accelerated Nephrotoxic Nephritis J. Am. Soc. Nephrol., July 1, 2006; 17(7): 1931 - 1939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G. Tipping Toll-Like Receptors: The Interface between Innate and Adaptive Immunity J. Am. Soc. Nephrol., July 1, 2006; 17(7): 1769 - 1771. [Full Text] [PDF]
|
|
|
|
|
|
G. Gatti, V. Rivero, R. D. Motrich, and M. Maccioni Prostate epithelial cells can act as early sensors of infection by up-regulating TLR4 expression and proinflammatory mediators upon LPS stimulation J. Leukoc. Biol., May 1, 2006; 79(5): 989 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. El-Achkar, X. Huang, Z. Plotkin, R. M. Sandoval, G. J. Rhodes, and P. C. Dagher Sepsis induces changes in the expression and distribution of Toll-like receptor 4 in the rat kidney Am J Physiol Renal Physiol, May 1, 2006; 290(5): F1034 - F1043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Ortega-Cava, S. Ishihara, M. A. K. Rumi, M. M. Aziz, H. Kazumori, T. Yuki, Y. Mishima, I. Moriyama, C. Kadota, N. Oshima, et al. Epithelial Toll-Like Receptor 5 Is Constitutively Localized in the Mouse Cecum and Exhibits Distinctive Down-Regulation during Experimental Colitis Clin. Vaccine Immunol., January 1, 2006; 13(1): 132 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Van der Meer, E Lipsic, R. Henning, K Boddeus, J van der Velden, A. Voors, D. van Veldhuisen, W. van Gilst, R. Schoemaker, J. Leemans, et al. Heart Failure after Myocardial Infarction--Benefit beyond Hemoglobin from Erythropoietin: Erythropoietin Induces Neovascularization and Improves Cardiac Function in Rats with Heart Failure after Myocardial Infarction J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3449 - 3454. [Full Text] [PDF]
|
|
|
|
|
|
J. C. Rice, T. Peng, J. S. Spence, H.-Q. Wang, R. M. Goldblum, B. Corthesy, and B. J. Nowicki Pyelonephritic Escherichia coli Expressing P Fimbriae Decrease Immune Response of the Mouse Kidney J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3583 - 3591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Netea, T. Azam, G. Ferwerda, S. E. Girardin, M. Walsh, J.-S. Park, E. Abraham, J.-M. Kim, D.-Y. Yoon, C. A. Dinarello, et al. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1{beta} and IL-6 production through a caspase 1-dependent mechanism PNAS, November 8, 2005; 102(45): 16309 - 16314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Gomariz, A. Arranz, C. Abad, M. Torroba, C. Martinez, F. Rosignoli, M. Garcia-Gomez, J. Leceta, and Y. Juarranz Time-course expression of Toll-like receptors 2 and 4 in inflammatory bowel disease and homeostatic effect of VIP J. Leukoc. Biol., August 1, 2005; 78(2): 491 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Miller, O. E. Sorensen, P. T. Liu, H. R. Jalian, D. Eshtiaghpour, B. E. Behmanesh, W. Chung, T. D. Starner, J. Kim, P. A. Sieling, et al. TGF-{alpha} Regulates TLR Expression and Function on Epidermal Keratinocytes J. Immunol., May 15, 2005; 174(10): 6137 - 6143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ueta, T. Nochi, M.-H. Jang, E. J. Park, O. Igarashi, A. Hino, S. Kawasaki, T. Shikina, T. Hiroi, S. Kinoshita, et al. Intracellularly Expressed TLR2s and TLR4s Contribution to an Immunosilent Environment at the Ocular Mucosal Epithelium J. Immunol., September 1, 2004; 173(5): 3337 - 3347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Armstrong, A. R. L. Medford, K. M. Uppington, J. Robertson, I. R. Witherden, T. D. Tetley, and A. B. Millar Expression of Functional Toll-Like Receptor-2 and -4 on Alveolar Epithelial Cells Am. J. Respir. Cell Mol. Biol., August 1, 2004; 31(2): 241 - 245. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Mahanonda, N. Sa-Ard-Iam, O. Charatkulangkun, A. Promsudthi, R.E. Schifferle, K. Yongvanichit, and S. Pichyangkul Monocyte Activation by Porphyromonas gingivalis LPS in Aggressive Periodontitis with the Use of Whole-blood Cultures J. Dent. Res., July 1, 2004; 83(7): 540 - 545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Feulner, M. Lu, JohnM. Shelton, M. Zhang, J. A. Richardson, and R. S. Munford Identification of Acyloxyacyl Hydrolase, a Lipopolysaccharide- Detoxifying Enzyme, in the Murine Urinary Tract Infect. Immun., June 1, 2004; 72(6): 3171 - 3178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kropf, M. A. Freudenberg, M. Modolell, H. P. Price, S. Herath, S. Antoniazi, C. Galanos, D. F. Smith, and I. Muller Toll-Like Receptor 4 Contributes to Efficient Control of Infection with the Protozoan Parasite Leishmania major Infect. Immun., April 1, 2004; 72(4): 1920 - 1928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Anders, B. Banas, and D. Schlondorff Signaling Danger: Toll-Like Receptors and their Potential Roles in Kidney Disease J. Am. Soc. Nephrol., April 1, 2004; 15(4): 854 - 867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Knapp, C. W. Wieland, C. van 't Veer, O. Takeuchi, S. Akira, S. Florquin, and T. van der Poll Toll-Like Receptor 2 Plays a Role in the Early Inflammatory Response to Murine Pneumococcal Pneumonia but Does Not Contribute to Antibacterial Defense J. Immunol., March 1, 2004; 172(5): 3132 - 3138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. N. Cunningham, Y. Wang, R. Guo, G. He, and R. J. Quigg Role of Toll-Like Receptor 4 in Endotoxin-Induced Acute Renal Failure J. Immunol., February 15, 2004; 172(4): 2629 - 2635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bals and P.S. Hiemstra Innate immunity in the lung: how epithelial cells fight against respiratory pathogens Eur. Respir. J., February 1, 2004; 23(2): 327 - 333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Guillot, S. Medjane, K. Le-Barillec, V. Balloy, C. Danel, M. Chignard, and M. Si-Tahar Response of Human Pulmonary Epithelial Cells to Lipopolysaccharide Involves Toll-like Receptor 4 (TLR4)-dependent Signaling Pathways: EVIDENCE FOR AN INTRACELLULAR COMPARTMENTALIZATION OF TLR4 J. Biol. Chem., January 23, 2004; 279(4): 2712 - 2718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Goldammer, H. Zerbe, A. Molenaar, H.-J. Schuberth, R. M. Brunner, S. R. Kata, and H.-M. Seyfert Mastitis Increases Mammary mRNA Abundance of {beta}-Defensin 5, Toll-Like-Receptor 2 (TLR2), and TLR4 but Not TLR9 in Cattle Clin. Vaccine Immunol., January 1, 2004; 11(1): 174 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Drennan, D. Nicolle, V. J. F. Quesniaux, M. Jacobs, N. Allie, J. Mpagi, C. Fremond, H. Wagner, C. Kirschning, and B. Ryffel Toll-Like Receptor 2-Deficient Mice Succumb to Mycobacterium tuberculosis Infection Am. J. Pathol., January 1, 2004; 164(1): 49 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Pawlinski, B. Pedersen, B. Kehrle, W. C. Aird, R. D. Frank, M. Guha, and N. Mackman Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model Blood, May 15, 2003; 101(10): 3940 - 3947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Ortega-Cava, S. Ishihara, M. A. K. Rumi, K. Kawashima, N. Ishimura, H. Kazumori, J. Udagawa, Y. Kadowaki, and Y. Kinoshita Strategic Compartmentalization of Toll-Like Receptor 4 in the Mouse Gut J. Immunol., April 15, 2003; 170(8): 3977 - 3985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Liu, A. A. Roberts, and T. Ganz By IL-1 Signaling, Monocyte-Derived Cells Dramatically Enhance the Epidermal Antimicrobial Response to Lipopolysaccharide J. Immunol., January 1, 2003; 170(1): 575 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Medvedev, A. Lentschat, L. M. Wahl, D. T. Golenbock, and S. N. Vogel Dysregulation of LPS-Induced Toll-Like Receptor 4-MyD88 Complex Formation and IL-1 Receptor-Associated Kinase 1 Activation in Endotoxin-Tolerant Cells J. Immunol., November 1, 2002; 169(9): 5209 - 5216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wang, P. L. Pedraza, H. I. Abdullah, J. C. McGiff, and N. R. Ferreri Calcium-sensing receptor-mediated TNF production in medullary thick ascending limb cells Am J Physiol Renal Physiol, November 1, 2002; 283(5): F963 - F970. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
