| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
and IL-4 Levels During In Vitro Polarization of Primary Murine CD4+ T Cells1
*
Immunology and
Cell Biology Programs, Memorial Sloan-Kettering Cancer Center, Sloan-Kettering Division, Weill Graduate School of Medical Sciences of Cornell University, New York, NY 10021
Following their activation, naive CD4+ T cells can
differentiate into one of two effector cell subsets, Th1 and Th2. These
two subsets have different cytokine secretion patterns and thus mediate
separate arms of the immune response. It has been established that the
fat-soluble vitamin D3 metabolite 1,25-dihydroxyvitamin
D3 (1,25(OH)2D3) and its nuclear
receptor, the vitamin D receptor, play an important role in the immune
system primarily through the transcriptional inhibition of cytokine
genes that either are required for Th1 differentiation or are products
of differentiated Th1 cells. Therefore, we wanted to test directly the
ability of 1,25(OH)2D3 to alter the Th
differentiation process. Our results indicate that
1,25(OH)2D3 inhibits not only the Th1 cytokine
IFN-
but also the Th2 cytokine IL-4 in naive CD62
ligand+CD4+ T cells during their in vitro
polarization. This effect is most dramatic when the ligand is present
from the onset of the differentiation process. If the ligand is added
after the polarization has ensued, the inhibition is significantly
diminished. In activated (CD62 ligand-CD4+) T
cells, 1,25(OH)2D3 is still able to inhibit
IFN- but has no effect on IL-4 production. Our results also indicate
that inhibition of these two cytokines in naive cells by vitamin D
receptor and its ligand is neither a result of a cell cycle block nor
an inhibition of Th1 or Th2 transcription factor expression but,
rather, at least in the case of Th2 differentiation, an attenuation of
IL-4 transcription by the receptor.
This article has been cited by other articles:
|
|
 |
|
  C.-C. Szeto and P. K.-T. Li The use of vitamin D analogues in chronic kidney diseases: possible mechanisms beyond bone and mineral metabolism NDT Plus, June 1, 2009; 2(3): 205 - 212. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tang, R. Zhou, D. Luger, W. Zhu, P. B. Silver, R. S. Grajewski, S.-B. Su, C.-C. Chan, L. Adorini, and R. R. Caspi Calcitriol Suppresses Antiretinal Autoimmunity through Inhibitory Effects on the Th17 Effector Response J. Immunol., April 15, 2009; 182(8): 4624 - 4632. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bouillon, G. Carmeliet, L. Verlinden, E. van Etten, A. Verstuyf, H. F. Luderer, L. Lieben, C. Mathieu, and M. Demay Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice Endocr. Rev., October 1, 2008; 29(6): 726 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Kovesdy, S. Ahmadzadeh, J. E. Anderson, and K. Kalantar-Zadeh Association of Activated Vitamin D Treatment and Mortality in Chronic Kidney Disease Arch Intern Med, February 25, 2008; 168(4): 397 - 403. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Cutolo and K. Otsa Review: Vitamin D, immunity and lupus Lupus, January 1, 2008; 17(1): 6 - 10. [Abstract] [PDF]
|
|
|
|
 |
|
 Y. Arnson, H. Amital, and Y. Shoenfeld Vitamin D and autoimmunity: new aetiological and therapeutic considerations Ann Rheum Dis, September 1, 2007; 66(9): 1137 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Baroni, M. Biffi, F. Benigni, A. Monno, D. Carlucci, G. Carmeliet, R. Bouillon, and D. D'Ambrosio VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3 J. Leukoc. Biol., January 1, 2007; 81(1): 250 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Daniel, H. H. Radeke, N. A. Sartory, N. Zahn, U. Zuegel, A. Steinmeyer, and J. Stein The New Low Calcemic Vitamin D Analog 22-Ene-25-Oxa-Vitamin D Prominently Ameliorates T Helper Cell Type 1-Mediated Colitis in Mice J. Pharmacol. Exp. Ther., November 1, 2006; 319(2): 622 - 631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Fretz, L. A. Zella, S. Kim, N. K. Shevde, and J. W. Pike 1,25-Dihydroxyvitamin D3 Regulates the Expression of Low-Density Lipoprotein Receptor-Related Protein 5 via Deoxyribonucleic Acid Sequence Elements Located Downstream of the Start Site of Transcription Mol. Endocrinol., September 1, 2006; 20(9): 2215 - 2230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, M. T. Cencioni, D. F. Angelini, G. Borsellino, L. Battistini, and C. F. Brosnan Transcriptional Profiling of {gamma}{delta} T Cells Identifies a Role for Vitamin D in the Immunoregulation of the V{gamma}9V{delta}2 Response to Phosphate-Containing Ligands J. Immunol., May 15, 2005; 174(10): 6144 - 6152. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Murase, K. K. Chan, T. J. Garite, D. M. Cooper, and G. D. Weinstein Hormonal Effect on Psoriasis in Pregnancy and Post Partum Arch Dermatol, May 1, 2005; 141(5): 601 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Cantorna and B. D. Mahon Mounting Evidence for Vitamin D as an Environmental Factor Affecting Autoimmune Disease Prevalence Experimental Biology and Medicine, December 1, 2004; 229(11): 1136 - 1142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Rhodes, L. A. Terry, J. Hope, R. G. Hewinson, and H. M. Vordermeier 1,25-Dihydroxyvitamin D3 and Development of Tuberculosis in Cattle Clin. Vaccine Immunol., November 1, 2003; 10(6): 1129 - 1135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gurlek, M. R. Pittelkow, and R. Kumar Modulation of Growth Factor/Cytokine Synthesis and Signaling by 1{alpha},25-Dihydroxyvitamin D3: Implications in Cell Growth and Differentiation Endocr. Rev., December 1, 2002; 23(6): 763 - 786. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
