The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Einav, S.
Right arrow Articles by Carroll, M. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Einav, S.
Right arrow Articles by Carroll, M. C.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Lupus
The Journal of Immunology, 2002, 168: 1036-1041.
Copyright © 2002 by The American Association of Immunologists

Complement C4 Is Protective for Lupus Disease Independent of C31

Shirit Einav, Olga O. Pozdnyakova, Minghe Ma and Michael C. Carroll2

Center for Blood Research and Department of Pediatrics, Harvard Medical School, Boston, MA 02115

The role of complement C3 in mediating systemic lupus erythematosus (SLE) was examined using a double-knockout C3nullC4null Fas (CD95)-deficient mouse model. Results from this study reveal significant lymphadenopathy, splenomegaly, elevated titers of anti-nuclear Abs and anti-dsDNA Abs, an increased number of anti-dsDNA-producing cells in ELISPOT assay, as well as severe glomerulonephritis in the double-deficient mice. Based on these clinical, serological, and histological parameters, we find that autoimmune disease in the double-knockout group is similar in severity to that in C4null lpr mice, but not to that in C3null lpr mice. The development of severe SLE in the absence of both classical and alternative complement pathways suggests that it is the absence of C4, and not the presence of C3, that is critical in SLE pathogenesis. Thus, complement C4 provides an important protective role against the development of SLE.




This article has been cited by other articles:


Home page
 JEMHome page
V. A. Gupta, M. L. Hermiston, G. Cassafer, D. I. Daikh, and A. Weiss
B cells drive lymphocyte activation and expansion in mice with the CD45 wedge mutation and Fas deficiency
J. Exp. Med., November 24, 2008; 205(12): 2755 - 2761.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
H. Al-Rayes, R. Al-Swailem, M. Arfin, S. Sobki, S. Rizvi, and M. Tariq
Lupus Around the World: Systemic lupus erythematosus and infections: a retrospective study in Saudis
Lupus, September 1, 2007; 16(9): 755 - 763.
[Abstract] [PDF]

Home page
 Am. J. Pathol.Home page
M. M. Markiewski and J. D. Lambris
The Role of Complement in Inflammatory Diseases From Behind the Scenes into the Spotlight
Am. J. Pathol., September 1, 2007; 171(3): 715 - 727.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
M Bijl, E Reefman, G Horst, P C Limburg, and C G M Kallenberg
Reduced uptake of apoptotic cells by macrophages in systemic lupus erythematosus: correlates with decreased serum levels of complement
Ann Rheum Dis, January 1, 2006; 65(1): 57 - 63.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. E. Wenderfer, B. Ke, T. J. Hollmann, R. A. Wetsel, H. Y. Lan, and M. C. Braun
C5a Receptor Deficiency Attenuates T Cell Function and Renal Disease in MRLlpr Mice
J. Am. Soc. Nephrol., December 1, 2005; 16(12): 3572 - 3582.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
B. Zachrau, D. Finke, K. Kropf, H.-J. Gosink, H. Kirchner, and S. Goerg
Antigen localization within the splenic marginal zone restores humoral immune response and IgG class switch in complement C4-deficient mice
Int. Immunol., December 1, 2004; 16(12): 1685 - 1690.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Moll, L. Nitschke, M. Carroll, J. V. Ravetch, and S. Izui
A Critical Role for Fc{gamma}RIIB in the Induction of Rheumatoid Factors
J. Immunol., October 1, 2004; 173(7): 4724 - 4728.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
R P Rother, C F Mojcik, and E W McCroskery
Inhibition of terminal complement: a novel therapeutic approach for the treatment of systemic lupus erythematosus
Lupus, May 1, 2004; 13(5): 328 - 334.
[Abstract] [PDF]

Home page
 Nephrol Dial TransplantHome page
K. Lhotta, R. Wurzner, H. J. Rumpelt, P. Eder, and G. Mayer
Membranous nephropathy in a patient with hereditary complete complement C4 deficiency
Nephrol. Dial. Transplant., April 1, 2004; 19(4): 990 - 993.
[Full Text] [PDF]

Home page
 LupusHome page
K Lhotta, R Wurzner, A R Rosenkranz, R Beer, A Rudisch, F Neumair, and G Mayer
Cerebral vasculitis in a patient with hereditary complete C4 deficiency and systemic lupus erythematosus
Lupus, February 1, 2004; 13(2): 139 - 141.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
R. J. Quigg
Complement and the Kidney
J. Immunol., October 1, 2003; 171(7): 3319 - 3324.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
L. Bao, M. Haas, D. M. Kraus, B. K. Hack, J. K. Rakstang, V. M. Holers, and R. J. Quigg
Administration of a Soluble Recombinant Complement C3 Inhibitor Protects Against Renal Disease in MRL/lpr Mice
J. Am. Soc. Nephrol., March 1, 2003; 14(3): 670 - 679.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.