| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Gastroenterology Division, Departments of Medicine and
Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115; and
Department of Microbiology, University of Colorado Health Sciences Center, Denver, CO 80262
Carcinoembryonic Ag cell adhesion molecule 1 (CEACAM1) consists of highly related homologs in humans and rodents that are characterized by significant alternate splicing generating isoforms capable of negative intracellular signaling by virtue of two immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic (cyt) tail. Although human T cells have been recently observed to express CEACAM1, the expression and function of CEACAM1 in mouse T cells have not been defined. Although resting mouse spleen T cells exhibited no evidence of CEACAM1 on the cell surface, CEACAM1 was rapidly up-regulated on CD4+ and CD8+ T cells after activation with either Con A or anti-CD3 without a requirement for either de novo transcription or translation due to the fact that CEACAM1 was present intracellularly before activation. Using a GST-CEACAM1-cytoplasmic tail fusion protein, it was shown that the cytoplasmic tail of CEACAM1 bound the src homology domain-containing phosphatase 1 and adaptor protein 1 complex in its phosphorylated and nonphosphorylated states, respectively. CEACAM1 ligation with an anti-CEACAM1 mAb resulted in inhibition of an allogeneic MLR and anti-CD3 plus anti-CD28 Ab-induced proliferation of spleen T cells in vitro and inhibition of a delayed-type hypersensitivity response to oxazolone in vivo. Inhibition of the delayed-type hypersensitivity response required that the anti-CEACAM1-specific mAb be present at the time of T cell sensitization. These studies support a role for CEACAM1 as a novel class of immunoreceptor tyrosine-based inhibition motif-bearing regulatory molecules on T cells that are active during early phases of the immune response in mice.
This article has been cited by other articles:
|
|
 |
|
  H. S. W. Lee, M. A. Ostrowski, and S. D. Gray-Owen CEACAM1 Dynamics during Neisseria gonorrhoeae Suppression of CD4+ T Lymphocyte Activation J. Immunol., May 15, 2008; 180(10): 6827 - 6835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Chen, L. Chen, S.-W. Qiao, T. Nagaishi, and R. S. Blumberg Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Inhibits Proximal TCR Signaling by Targeting ZAP-70 J. Immunol., May 1, 2008; 180(9): 6085 - 6093. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Yu, E. M. C. Chow, H. Wong, J. Gu, O. Mandelboim, S. D. Gray-Owen, and M. A. Ostrowski CEACAM1 (CD66a) Promotes Human Monocyte Survival via a Phosphatidylinositol 3-Kinase- and AKT-dependent Pathway J. Biol. Chem., December 22, 2006; 281(51): 39179 - 39193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Albarran-Somoza, R. Franco-Topete, V. Delgado-Rizo, F. Cerda-Camacho, L. Acosta-Jimenez, M. Lopez-Botet, and A. Daneri-Navarro CEACAM1 in Cervical Cancer and Precursor Lesions: Association With Human Papillomavirus Infection J. Histochem. Cytochem., December 1, 2006; 54(12): 1393 - 1399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. B. Frey and N. Monu Effector-phase tolerance: another mechanism of how cancer escapes antitumor immune response J. Leukoc. Biol., April 1, 2006; 79(4): 652 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhou and S. Perlman Preferential Infection of Mature Dendritic Cells by Mouse Hepatitis Virus Strain JHM J. Virol., March 1, 2006; 80(5): 2506 - 2514. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Azuz-Lieberman, G. Markel, S. Mizrahi, R. Gazit, J. Hanna, H. Achdout, R. Gruda, G. Katz, T. I. Arnon, S. Battat, et al. The involvement of NK cells in ankylosing spondylitis Int. Immunol., July 1, 2005; 17(7): 837 - 845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Servin Pathogenesis of Afa/Dr Diffusely Adhering Escherichia coli Clin. Microbiol. Rev., April 1, 2005; 18(2): 264 - 292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ramakrishna, C. C. Bergmann, K. V. Holmes, and S. A. Stohlman Expression of the Mouse Hepatitis Virus Receptor by Central Nervous System Microglia J. Virol., July 15, 2004; 78(14): 7828 - 7832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Turner, E. M. Hemmila, N. Beauchemin, and K. V. Holmes Receptor-Dependent Coronavirus Infection of Dendritic Cells J. Virol., May 15, 2004; 78(10): 5486 - 5490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chen, H. Iijima, T. Nagaishi, A. Nakajima, S. Russell, R. Raychowdhury, V. Morales, C. E. Rudd, N. Utku, and R. S. Blumberg Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 1 Isoforms Alternatively Inhibit and Costimulate Human T Cell Function J. Immunol., March 15, 2004; 172(6): 3535 - 3543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-J. Chen and J. E. Shively The Cell-Cell Adhesion Molecule Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 1 Inhibits IL-2 Production and Proliferation in Human T Cells by Association with Src Homology Protein-1 and Down-Regulates IL-2 Receptor J. Immunol., March 15, 2004; 172(6): 3544 - 3552. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Iijima, M. F. Neurath, T. Nagaishi, J. N. Glickman, E. E. Nieuwenhuis, A. Nakajima, D. Chen, I. J. Fuss, N. Utku, D. N. Lewicki, et al. Specific Regulation of T Helper Cell 1-mediated Murine Colitis by CEACAM1 J. Exp. Med., February 17, 2004; 199(4): 471 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kirshner, D. Schumann, and J. E. Shively CEACAM1, a Cell-Cell Adhesion Molecule, Directly Associates with Annexin II in a Three-dimensional Model of Mammary Morphogenesis J. Biol. Chem., December 12, 2003; 278(50): 50338 - 50345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Fournes, J. Farrah, M. Olson, N. Lamarche-Vane, and N. Beauchemin Distinct Rho GTPase Activities Regulate Epithelial Cell Localization of the Adhesion Molecule CEACAM1: Involvement of the CEACAM1 Transmembrane Domain Mol. Cell. Biol., October 15, 2003; 23(20): 7291 - 7304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Greicius, E. Severinson, N. Beauchemin, B. Obrink, and B. B. Singer CEACAM1 is a potent regulator of B cell receptor complex-induced activation J. Leukoc. Biol., July 1, 2003; 74(1): 126 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Finkenzeller, B. Fischer, S. Lutz, H. Schrewe, T. Shimizu, and W. Zimmermann Carcinoembryonic Antigen-Related Cell Adhesion Molecule 10 Expressed Specifically Early in Pregnancy in the Decidua Is Dispensable for Normal Murine Development Mol. Cell. Biol., January 1, 2003; 23(1): 272 - 279. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
