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The Journal of Immunology, 2002, 168: 782-792.
Copyright © 2002 by The American Association of Immunologists

Identification of Mouse Langerin/CD207 in Langerhans Cells and Some Dendritic Cells of Lymphoid Tissues1

Jenny Valladeau*, Valérie Clair-Moninot*, Colette Dezutter-Dambuyant{dagger}, Jean-Jacques Pin*, Adrien Kissenpfennig§, Marie-Genevieve Mattéi{ddagger}, Smina Ait-Yahia*, Elizabeth E. M. Bates*, Bernard Malissen§, Franz Koch, François Fossiez*, Nikolaus Romani, Serge Lebecque* and Sem Saeland2,*

* Schering-Plough Laboratory for Immunological Research, Dardilly, France; {dagger} Institut National de la Santé et de la Recherche Médicale Unité 346, Centre Hospitalier Edouard Herriot, Lyon, France; {ddagger} Institut National de la Santé et de la Recherche Médicale Unité 491, Faculté de Médecine, Marseille, France; § Centre d’Immunologie, Institut National de la Santé et de la Recherche Médicale-Centre National de la Recherche Scientifique, Marseille, France; Department of Dermatology, University of Innsbruck, Innsbruck, Austria

Human (h)Langerin/CD207 is a C-type lectin of Langerhans cells (LC) that induces the formation of Birbeck granules (BG). In this study, we have cloned a cDNA-encoding mouse (m)Langerin. The predicted protein is 66% homologous to hLangerin with conservation of its particular features. The organization of human and mouse Langerin genes are similar, consisting of six exons, three of which encode the carbohydrate recognition domain. The mLangerin gene maps to chromosome 6D, syntenic to the human gene on chromosome 2p13. mLangerin protein, detected by a mAb as a 48-kDa species, is abundant in epidermal LC in situ and is down-regulated upon culture. A subset of cells also expresses mLangerin in bone marrow cultures supplemented with TGF-{beta}. Notably, dendritic cells in thymic medulla are mLangerin-positive. By contrast, only scattered cells express mLangerin in lymph nodes and spleen. mLangerin mRNA is also detected in some nonlymphoid tissues (e.g., lung, liver, and heart). Similarly to hLangerin, a network of BG form upon transfection of mLangerin cDNA into fibroblasts. Interestingly, substitution of a conserved residue (Phe244 to Leu) within the carbohydrate recognition domain transforms the BG in transfectant cells into structures resembling cored tubules, previously described in mouse LC. Our findings should facilitate further characterization of mouse LC, and provide insight into a plasticity of dendritic cell organelles which may have important functional consequences.




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