The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morrison, S. J.
Right arrow Articles by Clarke, M. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morrison, S. J.
Right arrow Articles by Clarke, M. F.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
Medline Plus Health Information
*Stem Cells
The Journal of Immunology, 2002, 168: 635-642.
Copyright © 2002 by The American Association of Immunologists

A Genetic Determinant That Specifically Regulates the Frequency of Hematopoietic Stem Cells1

Sean J. Morrison*,{dagger},{ddagger}, Dalong Qian{dagger}, Libuse Jerabek§, Bonnie A. Thiel, In-Kyung Park{dagger}, Preston S. Ford{dagger}, Mark J. Kiel*,{dagger},{ddagger}, Nicholas J. Schork, Irving L. Weissman§ and Michael F. Clarke2,{dagger}

* Howard Hughes Medical Institute and Departments of {dagger} Internal Medicine and {ddagger} Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109; § Departments of Pathology and Developmental Biology, Stanford University, Stanford, CA 94305; and Department of Genetics and Center for Human Genetics, Case Western Reserve University, Cleveland, OH 44106

The regulation of hematopoietic stem cell (HSC) homeostasis is not well understood. We screened for genetic polymorphisms that were linked to differences between mouse strains in the numbers of long-term reconstituting HSCs or restricted progenitors in the bone marrow. AKR/J mice had significantly higher frequencies and numbers of both HSCs and restricted progenitors in their bone marrow than C57BL/Ka-Thy-1.1 mice. The C57BL/Ka-Thy-1.1 alleles were partially dominant. A locus on chromosome 17, including the H-2 complex, was significantly linked to the frequency of long-term self-renewing HSCs but showed no evidence of linkage to the frequency of restricted progenitors. Conversely, a chromosome 1 locus exhibited suggestive linkage to restricted progenitor frequencies but was not linked to HSC frequency. This demonstrates that there are distinct genetic determinants of the frequencies of HSCs and restricted progenitors in vivo. The AKR/J chromosome 17 locus was not sufficient to increase HSC frequencies when bred onto a C57BL background. This suggests that to affect HSC frequencies, the product(s) of this locus likely depend on interactions with unlinked modifying loci.




This article has been cited by other articles:


Home page
 Stem CellsHome page
U. Ganapati, H. T. Tan, M. Lynch, M. Dolezal, S. de Vos, and J. C. Gasson
Modeling Notch Signaling in Normal and Neoplastic Hematopoiesis: Global Gene Expression Profiling in Response to Activated Notch Expression
Stem Cells, August 1, 2007; 25(8): 1872 - 1880.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Martelli, B. Ghinassi, B. Panetta, E. Alfani, V. Gatta, A. Pancrazzi, C. Bogani, A. M. Vannucchi, F. Paoletti, G. Migliaccio, et al.
Variegation of the phenotype induced by the Gata1low mutation in mice of different genetic backgrounds
Blood, December 15, 2005; 106(13): 4102 - 4113.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Henckaerts, J. C. Langer, J. Orenstein, and H.-W. Snoeck
The Positive Regulatory Effect of TGF-{beta}2 on Primitive Murine Hemopoietic Stem and Progenitor Cells Is Dependent on Age, Genetic Background, and Serum Factors
J. Immunol., August 15, 2004; 173(4): 2486 - 2493.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Henckaerts, J. C. Langer, and H.-W. Snoeck
Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice
Blood, July 15, 2004; 104(2): 374 - 379.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y.-A. Cao, A. J. Wagers, A. Beilhack, J. Dusich, M. H. Bachmann, R. S. Negrin, I. L. Weissman, and C. H. Contag
Shifting foci of hematopoiesis during reconstitution from single stem cells
PNAS, January 6, 2004; 101(1): 221 - 226.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
J. C. Langer, E. Henckaerts, J. Orenstein, and H.-W. Snoeck
Quantitative Trait Analysis Reveals Transforming Growth Factor-{beta}2 as a Positive Regulator of Early Hematopoietic Progenitor and Stem Cell Function
J. Exp. Med., January 5, 2004; 199(1): 5 - 14.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. O. Schonland, C. Lopez, T. Widmann, J. Zimmer, E. Bryl, J. J. Goronzy, and C. M. Weyand
Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages
PNAS, November 11, 2003; 100(23): 13471 - 13476.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. de Haan, L. V. Bystrykh, E. Weersing, B. Dontje, H. Geiger, N. Ivanova, I. R. Lemischka, E. Vellenga, and G. Van Zant
A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover
Blood, August 28, 2002; 100(6): 2056 - 2062.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.