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I-B Kinase Is Critical for B Cell Proliferation and Antibody Response

Division of Hematology-Oncology, Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390

The NF-B proteins are critical in the regulation of the immune and inflammatory response. Stimulation of the NF-B pathway leads to increases in I-B kinase (IKK) kinase activity to result in the enhanced phosphorylation and degradation of I-B and the translocation of the NF-B proteins from the cytoplasm to the nucleus. In this study, a dominant-negative IKK mutant expressed from the IgH promoter was used to generate transgenic mice to address the role of IKK on B cell function. Although these transgenic mice were defective in activating the NF-B pathway in B cells, they exhibited no defects in B lymphocyte development or basal Ig levels. However, they exhibited defects in the cell cycle progression and proliferation of B cells in response to treatment with LPS, anti-CD40, and anti-IgM. Furthermore, selective defects in the production of specific Ig subclasses in response to both T-dependent and T-independent Ags were noted. These results suggest that IKK is critical for the proliferation of B cells and the control of some aspects of the humoral response.

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