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* Division of Developmental and Clinical Immunology, Departments of
Medicine,
Pediatrics,
Microbiology, and
¶ Pathology,
|| Howard Hughes Medical Institute, University of Alabama, Birmingham, AL 35294
The effect of steroid treatment on the thymic output of T cells was
examined in an avian model. Recent thymic emigrants in chickens
transiently express the chicken T cell Ag 1 thymocyte marker,
and thymic function can be monitored indirectly by measuring the levels
of TCR gene rearrangement excision circles in peripheral T
cells. Both parameters were used to show that intensive steroid
treatment induces thymic involution and a profound reduction in the
supply of naive T cells to the periphery. Conversely, resident T cells
in the peripheral lymphocyte pool were relatively spared. Thymopoiesis
immediately recovered following cessation of steroid treatment,
concurrent with restoration of the thymic output of newly formed T
cells. Repopulation of the peripheral T cell pool recapitulated the
ontogenetic pattern of 
T cell replenishment before 
T cell
reseeding, thereby indicating the complete recovery of thymic function
after a course of steroid treatment.
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