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5 Triple-Deficient Mice Show Impaired B Cell Development but Functional Allelic Exclusion of the IgH Locus1
* Basel Institute for Immunology, Basel, Switzerland; and
Developmental Immunology, Babraham Institute, Cambridge, United Kingdom
At the precursor B cell stage during bone marrow B cell
development, Ig µH chain associates with surrogate L (SL) chain,
which is encoded by the three genes VpreB1,
VpreB2, and 
5, to form the pre-B cell
receptor (pre-BCR). Surface expression of the pre-BCR is believed to
signal both proliferation and allelic exclusion of the
IgH locus. Mice which lack either
VpreB1/VpreB2 or 5 show
a lack of precursor B cell expansion but normal IgH
allelic exclusion. This would suggest that one of either 5 or VpreB
can make a pre-BCR-like complex which is still able to signal allelic
exclusion but not proliferation. To investigate this, we established
mice lacking all components of the SL chain. These mice showed severely
impaired B cell development which was similar to that previously found
in mice lacking either 5 or
VpreB1/VpreB2. Surprisingly, the
IgH locus was still allelically excluded and thus the SL
chain appears not to be involved in allelic
exclusion.
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