| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Food Engineering and Biotechnology, Technion, Haifa, Israel; and
Department of Gene Regulation and Differentiation, Gesellschaft für Biotechnologische Forschung, Braunschweig, Germany
Type I IFNs cause the induction of a subset of genes termed
IFN-stimulated genes (ISGs), which harbor a specific DNA element,
IFN-stimulated response element (ISRE). This ISRE confers the
responsiveness to the IFN signal through the binding of a family of
transcription factors designated IFN regulatory factors (IRFs). Some
IRFs can bind to the DNA alone, such as IRF-1, which elicits
transcriptional activation, or IRF-2, which leads to transcriptional
repression. In addition, these factors associate with IRF-8/IFN
consensus sequence binding protein (ICSBP), an immune cell-restricted
IRF, and the assembled heterocomplexes lead to synergistic repression
of ISRE elements. ISG15 is a prototype ISG that contains a
well-characterized ISRE. Here we show that PU.1, an ETS member
essential for myeloid/lymphoid cell differentiation, forms
heterocomplexes with the immune-restricted IRFs, IRF-8\/ICSBP and
IRF-4, which lead to transcriptional activation of ISG15. These data
allowed the characterization of a subset of ISREs designated ETS/IRF
response element (EIRE), which are differentially regulated in immune
cells. EIREs are unique in their ability to recruit different factors
to an assembled enhanceosomes. In nonimmune cells the factors will
mainly include IRF members, while cell type-restricted factors, such as
PU.1, IRF-8\/ICSBP, and IRF-4, will be recruited in immune cells. IRF
heterocomplex formation leads to transcriptional repression, and
conversely, PU.1/IRFs heterocomplex formation leads to transcriptional
activation. The fact that IRF-8\/ICSBP is an IFN-
-induced factor
explains why some of the EIREs are also induced by type II IFN. Our
results lay the molecular basis for the unique regulation of ISGs,
harboring EIRE, in immune cells.
This article has been cited by other articles:
|
|
 |
|
  Y.-J. Lou, X.-R. Pan, P.-M. Jia, D. Li, S. Xiao, Z.-L. Zhang, S.-J. Chen, Z. Chen, and J.-H. Tong IFR-9/STAT2 Functional Interaction Drives Retinoic Acid-Induced Gene G Expression Independently of STAT1 Cancer Res., April 15, 2009; 69(8): 3673 - 3680. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Zimmerer, A. M. Lehman, A. S. Ruppert, C. W. Noble, T. Olencki, M. J. Walker, K. Kendra, and W. E. Carson III IFN-{alpha}-2b-Induced Signal Transduction and Gene Regulation in Patient Peripheral Blood Mononuclear Cells Is Not Enhanced by a Dose Increase from 5 to 10 Megaunits/m2 Clin. Cancer Res., March 1, 2008; 14(5): 1438 - 1445. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Yang, M. Thangaraju, D. D. Browning, Z. Dong, B. Korchin, D. C. Lev, V. Ganapathy, and K. Liu IFN Regulatory Factor 8 Mediates Apoptosis in Nonhemopoietic Tumor Cells via Regulation of Fas Expression J. Immunol., October 1, 2007; 179(7): 4775 - 4782. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schroder, M. Lichtinger, K. M. Irvine, K. Brion, A. Trieu, I. L. Ross, T. Ravasi, K. J. Stacey, M. Rehli, D. A. Hume, et al. PU.1 and ICSBP control constitutive and IFN-{gamma}-regulated Tlr9 gene expression in mouse macrophages J. Leukoc. Biol., June 1, 2007; 81(6): 1577 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Zimmerer, G. B. Lesinski, S. V. Kondadasula, V. I. Karpa, A. Lehman, A. RayChaudhury, B. Becknell, and W. E. Carson III IFN-{alpha}-Induced Signal Transduction, Gene Expression, and Antitumor Activity of Immune Effector Cells Are Negatively Regulated by Suppressor of Cytokine Signaling Proteins J. Immunol., April 15, 2007; 178(8): 4832 - 4845. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Dror, N. Rave-Harel, A. Burchert, A. Azriel, T. Tamura, P. Tailor, A. Neubauer, K. Ozato, and B.-Z. Levi Interferon Regulatory Factor-8 Is Indispensable for the Expression of Promyelocytic Leukemia and the Formation of Nuclear Bodies in Myeloid Cells J. Biol. Chem., February 23, 2007; 282(8): 5633 - 5640. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. C. Huang, K. E. Duffy, L. R. San Mateo, B. Y. Amegadzie, R. T. Sarisky, and M. L. Mbow A pathway analysis of poly(I:C)-induced global gene expression change in human peripheral blood mononuclear cells Physiol Genomics, September 14, 2006; 26(2): 125 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Liu and X. Ma Interferon Regulatory Factor 8 Regulates RANTES Gene Transcription in Cooperation with Interferon Regulatory Factor-1, NF-{kappa}B, and PU.1 J. Biol. Chem., July 14, 2006; 281(28): 19188 - 19195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Liu, M. Mendicino, Q. Ning, A. Ghanekar, W. He, I. McGilvray, I. Shalev, D. Pivato, D. A. Clark, M. J. Phillips, et al. Cytokine-Induced Hepatic Apoptosis Is Dependent on FGL2/Fibroleukin: The Role of Sp1/Sp3 and STAT1/PU.1 Composite cis Elements. J. Immunol., June 1, 2006; 176(11): 7028 - 7038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Wang, R. M. Baron, G. Zhu, M. Joo, J. W. Christman, E. S. Silverman, M. A. Perrella, R. J. Riese, and M. Cernadas PU.1 Regulates Cathepsin S Expression in Professional APCs J. Immunol., January 1, 2006; 176(1): 275 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. F. Eisenbeis, G. B. Lesinski, M. Anghelina, R. Parihar, D. Valentino, J. Liu, P. Nadella, P. Sundaram, D. C. Young, M. Sznol, et al. Phase I Study of the Sequential Combination of Interleukin-12 and Interferon Alfa-2b in Advanced Cancer: Evidence for Modulation of Interferon Signaling Pathways by Interleukin-12 J. Clin. Oncol., December 1, 2005; 23(34): 8835 - 8844. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Laricchia-Robbio, T. Tamura, T. Karpova, B. L. Sprague, J. G. McNally, and K. Ozato Partner-regulated interaction of IFN regulatory factor 8 with chromatin visualized in live macrophages PNAS, October 4, 2005; 102(40): 14368 - 14373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tamura, P. Thotakura, T. S. Tanaka, M. S. H. Ko, and K. Ozato Identification of target genes and a unique cis element regulated by IRF-8 in developing macrophages Blood, September 15, 2005; 106(6): 1938 - 1947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. V. Pedchenko, G. Y. Park, M. Joo, T. S. Blackwell, and J. W. Christman Inducible binding of PU.1 and interacting proteins to the Toll-like receptor 4 promoter during endotoxemia Am J Physiol Lung Cell Mol Physiol, September 1, 2005; 289(3): L429 - L437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Narasimhan, M. Wang, Z. Fu, J. M. Klein, A. L. Haas, and J.-J. P. Kim Crystal Structure of the Interferon-induced Ubiquitin-like Protein ISG15 J. Biol. Chem., July 22, 2005; 280(29): 27356 - 27365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Ho Sui, J. R. Mortimer, D. J. Arenillas, J. Brumm, C. J. Walsh, B. P. Kennedy, and W. W. Wasserman oPOSSUM: identification of over-represented transcription factor binding sites in co-expressed genes Nucleic Acids Res., June 2, 2005; 33(10): 3154 - 3164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Gautier, M. Humbert, F. Deauvieau, M. Scuiller, J. Hiscott, E. E.M. Bates, G. Trinchieri, C. Caux, and P. Garrone A type I interferon autocrine-paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells J. Exp. Med., May 2, 2005; 201(9): 1435 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tamura, P. Tailor, K. Yamaoka, H. J. Kong, H. Tsujimura, J. J. O'Shea, H. Singh, and K. Ozato IFN Regulatory Factor-4 and -8 Govern Dendritic Cell Subset Development and Their Functional Diversity J. Immunol., March 1, 2005; 174(5): 2573 - 2581. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. D. Sgarlato, C. L. Eastman, and H. H. Sussman Panel of Genes Transcriptionally Up-regulated in Squamous Cell Carcinoma of the Cervix Identified by Representational Difference Analysis, Confirmed by Macroarray, and Validated by Real-Time Quantitative Reverse Transcription-PCR Clin. Chem., January 1, 2005; 51(1): 27 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. B. Lesinski, S. V. Kondadasula, T. Crespin, L. Shen, K. Kendra, M. Walker, and W. E. Carson III Multiparametric Flow Cytometric Analysis of Inter-Patient Variation in STAT1 Phosphorylation Following Interferon Alfa Immunotherapy J Natl Cancer Inst, September 1, 2004; 96(17): 1331 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Alter-Koltunoff, S. Ehrlich, N. Dror, A. Azriel, M. Eilers, H. Hauser, H. Bowen, C. H. Barton, T. Tamura, K. Ozato, et al. Nramp1-mediated Innate Resistance to Intraphagosomal Pathogens Is Regulated by IRF-8, PU.1, and Miz-1 J. Biol. Chem., November 7, 2003; 278(45): 44025 - 44032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chaussabel, R. T. Semnani, M. A. McDowell, D. Sacks, A. Sher, and T. B. Nutman Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites Blood, July 15, 2003; 102(2): 672 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hashmueli, M. Gleit-Kielmanowicz, D. Meraro, A. Azriel, D. Melamed, and B.-Z. Levi A truncated IFN-regulatory factor-8\IFN consensus sequence-binding protein acts as dominant-negative, interferes with endogenous protein-protein interactions and leads to apoptosis of immune cells Int. Immunol., July 1, 2003; 15(7): 807 - 815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. O'Reilly, C. M. Quinn, T. El-Shanawany, S. Gordon, and D. R. Greaves Multiple Ets Factors and Interferon Regulatory Factor-4 Modulate CD68 Expression in a Cell Type-specific Manner J. Biol. Chem., June 6, 2003; 278(24): 21909 - 21919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Barnes, A. E. Field, and P. M. Pitha-Rowe Virus-induced Heterodimer Formation between IRF-5 and IRF-7 Modulates Assembly of the IFNA Enhanceosome in Vivo and Transcriptional Activity of IFNA Genes J. Biol. Chem., May 2, 2003; 278(19): 16630 - 16641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. P. Gobin, P. Biesta, and P. J. Van den Elsen Regulation of human beta 2-microglobulin transactivation in hematopoietic cells Blood, April 15, 2003; 101(8): 3058 - 3064. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
