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* Walter and Eliza Hall Institute of Medical Research, Post Office Royal Melbourne Hospital, and
Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia; and
Department of Medicine, Division of Hematology/Oncology, Weill Medical College of Cornell University, New York, NY 10021
Cross-presentation allows the processing of Ags from donor cells
into the MHC class I presentation pathway of dendritic cells (DCs).
This is important for the generation of cytotoxic T cell immunity and
for induction of self tolerance. Apoptotic cells are reported to be
efficient targets for cross-presentation, and in vitro studies using
human DCs have implicated CD36 in their capture. In support of a role
for CD36 in cross-presentation, we show that this molecule is
differentially expressed by CD8+ splenic DCs, which
previously have been identified as responsible for cross-presentation
in the mouse. Three different cross-presentation models were examined
for their dependence on CD36. These included cross-priming to
OVA-coated spleen cells and cross-tolerance to OVA transgenically
expressed in the pancreatic islet 
cells under constitutive
conditions or during cell destruction. In these models, CD36
knockout DCs were equivalent to wild-type DCs in their capacity to
cross-present either foreign or self Ags, indicating that CD36 is not
essential for cross-presentation of cellular Ags in
vivo.
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