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Cutting Edge |
* Unité de Défense Innée et Inflammation, Institut Pasteur, Institut National de la Santé et de la Recherche Médicale, Unité 485, Paris, France;
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Cincinnati, Cincinnati, OH 45267; and
Department of Medicine, Division of Infectious Diseases, University of Massachusetts Medical School, Worcester, MA 01655
The collectin surfactant protein-A (SP-A) is involved in the
innate host defense and the regulation of inflammatory processes in the
lung. In this work we investigated the molecular mechanisms related to
the immunostimulatory activity of SP-A using macrophages from C3H/HeJ
mice, which carry an inactivating mutation in the Toll-like receptor
(TLR)4 gene, and TLR4-transfected Chinese hamster ovary cells. We
demonstrate that SP-A-induced activation of the NF-
B signaling
pathway and up-regulation of cytokine synthesis such as TNF-
and
IL-10 are critically dependent on the TLR4 functional complex. These
findings support the concept that TLR4 is a pattern recognition
receptor that signals in response to both foreign pathogens and
endogenous host mediators.
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W. Huang, G. Wang, D. S. Phelps, H. Al-Mondhiry, and J. Floros Human SP-A genetic variants and bleomycin-induced cytokine production by THP-1 cells: effect of ozone-induced SP-A oxidation Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L546 - L553. [Abstract] [Full Text] [PDF]
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J. F. Alcorn and J. R. Wright Surfactant protein A inhibits alveolar macrophage cytokine production by CD14-independent pathway Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L129 - L136. [Abstract] [Full Text] [PDF]
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L. G. Vazquez de Lara, T. M. Umstead, S. E. Davis, and D. S. Phelps Surfactant protein A increases matrix metalloproteinase-9 production by THP-1 cells Am J Physiol Lung Cell Mol Physiol, October 1, 2003; 285(4): L899 - L906. [Abstract] [Full Text] [PDF]
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S. Chabot, L. Salez, F. X. McCormack, L. Touqui, and M. Chignard Surfactant Protein A Inhibits Lipopolysaccharide-Induced In Vivo Production of Interleukin-10 by Mononuclear Phagocytes during Lung Inflammation Am. J. Respir. Cell Mol. Biol., March 1, 2003; 28(3): 347 - 353. [Abstract] [Full Text] [PDF]
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I. Caramalho, T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide J. Exp. Med., February 17, 2003; 197(4): 403 - 411. [Abstract] [Full Text] [PDF]
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