| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, and
Solution-Oriented Research for Science and Technology of Japan Science and Technology Corp., Suita, Osaka, Japan
Macrophages produce a large amount of PGE2 during
inflammation. This lipid mediator modulates various immune responses.
PGE2 acts on macrophages and inhibits production of
cytokines such as TNF-
and IL-12. Membrane-bound
glutathione-dependent PGE2 synthase (mPGES) has been shown
to be a terminal enzyme of the cyclooxygenase-2-mediated
PGE2 biosynthesis. Here we identified mPGES as a molecule
that is induced by LPS in macrophages. The expression of mPGES was not
induced by LPS in mice lacking Toll-like receptor 4 or MyD88.
Furthermore, mice deficient in NF-IL6 showed neither induction of mPGES
nor biosynthesis of PGE2 in response to LPS, indicating
that mPGES expression in response to LPS is regulated by a Toll-like
receptor 4/MyD88/NF-IL6-dependent signaling pathway. We generated
mPGES-deficient mice and investigated the role of mPGES in vivo. The
mice showed no augmentation of the PGE2 production in
response to LPS. However, they were not impaired in the LPS-induced
production of inflammatory cytokines and showed normal response to the
LPS-induced shock. Thus, mPGES is critically involved in the
biosynthesis of PGE2 induced by LPS, but is dispensable for
the modulation of inflammatory responses.
This article has been cited by other articles:
|
|
 |
|
  Y.-C. Lu, I. Kim, E. Lye, F. Shen, N. Suzuki, S. Suzuki, S. Gerondakis, S. Akira, S. L. Gaffen, W.-C. Yeh, et al. Differential Role for c-Rel and C/EBP{beta}/{delta} in TLR-Mediated Induction of Proinflammatory Cytokines J. Immunol., June 1, 2009; 182(11): 7212 - 7221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Nilsberth, L. Elander, N. Hamzic, M. Norell, J. Lonn, L. Engstrom, and A. Blomqvist The Role of Interleukin-6 in Lipopolysaccharide-Induced Fever by Mechanisms Independent of Prostaglandin E2 Endocrinology, April 1, 2009; 150(4): 1850 - 1860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Herath, S. T. Lilly, D. P. Fischer, E. J. Williams, H. Dobson, C. E. Bryant, and I. M. Sheldon Bacterial Lipopolysaccharide Induces an Endocrine Switch from Prostaglandin F2{alpha} to Prostaglandin E2 in Bovine Endometrium Endocrinology, April 1, 2009; 150(4): 1912 - 1920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Kojima, M. Kapoor, L. Yang, E. L. Fleishaker, M. R. Ward, S. U. Monrad, P. C. Kottangada, C. Q. Pace, J. A. Clark, J. G. Woodward, et al. Defective Generation of a Humoral Immune Response Is Associated with a Reduced Incidence and Severity of Collagen-Induced Arthritis in Microsomal Prostaglandin E Synthase-1 Null Mice J. Immunol., June 15, 2008; 180(12): 8361 - 8368. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nakanishi, D. C. Montrose, P. Clark, P. R. Nambiar, G. S. Belinsky, K. P. Claffey, D. Xu, and D. W. Rosenberg Genetic Deletion of mPGES-1 Suppresses Intestinal Tumorigenesis Cancer Res., May 1, 2008; 68(9): 3251 - 3259. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Minami, K. Shimizu, Y. Okamoto, E. Folco, M.-L. Ilasaca, M. W. Feinberg, M. Aikawa, and P. Libby Prostaglandin E Receptor Type 4-associated Protein Interacts Directly with NF-{kappa}B1 and Attenuates Macrophage Activation J. Biol. Chem., April 11, 2008; 283(15): 9692 - 9703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Into, M. Inomata, M. Nakashima, K.-i. Shibata, H. Hacker, and K. Matsushita Regulation of MyD88-Dependent Signaling Events by S Nitrosylation Retards Toll-Like Receptor Signal Transduction and Initiation of Acute-Phase Immune Responses Mol. Cell. Biol., February 15, 2008; 28(4): 1338 - 1347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. E Ackerman IV, T. L.S Summerfield, D. D Vandre, J. M Robinson, and D. A Kniss Nuclear Factor-Kappa B Regulates Inducible Prostaglandin E Synthase Expression in Human Amnion Mesenchymal Cells Biol Reprod, January 1, 2008; 78(1): 68 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nagamachi, D. Sakata, K. Kabashima, T. Furuyashiki, T. Murata, E. Segi-Nishida, K. Soontrapa, T. Matsuoka, Y. Miyachi, and S. Narumiya Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1 J. Exp. Med., November 26, 2007; 204(12): 2865 - 2874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamashita, T. Shinohara, S. Tsuji, Q. N. Myrvik, A. Nishiyama, R. A. Henriksen, and Y. Shibata Catalytically Inactive Cyclooxygenase 2 and Absence of Prostaglandin E2 Biosynthesis in Murine Peritoneal Macrophages following In Vivo Phagocytosis of Heat-Killed Mycobacterium bovis Bacillus Calmette-Guerin J. Immunol., November 15, 2007; 179(10): 7072 - 7078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Uematsu, T. Kaisho, T. Tanaka, M. Matsumoto, M. Yamakami, H. Omori, M. Yamamoto, T. Yoshimori, and S. Akira The C/EBPbeta Isoform 34-kDa LAP Is Responsible for NF-IL-6-Mediated Gene Induction in Activated Macrophages, but Is Not Essential for Intracellular Bacteria Killing J. Immunol., October 15, 2007; 179(8): 5378 - 5386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamamoto, S. Uematsu, T. Okamoto, Y. Matsuura, S. Sato, H. Kumar, T. Satoh, T. Saitoh, K. Takeda, K. J. Ishii, et al. Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency J. Exp. Med., September 3, 2007; 204(9): 2233 - 2239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Samuelsson, R. Morgenstern, and P.-J. Jakobsson Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target Pharmacol. Rev., September 1, 2007; 59(3): 207 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mosca, N. Polentarutti, G. Mangano, C. Apicella, A. Doni, F. Mancini, M. De Bortoli, I. Coletta, L. Polenzani, G. Santoni, et al. Regulation of the microsomal prostaglandin E synthase-1 in polarized mononuclear phagocytes and its constitutive expression in neutrophils J. Leukoc. Biol., August 1, 2007; 82(2): 320 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Lovgren, M. Kovarova, and B. H. Koller cPGES/p23 Is Required for Glucocorticoid Receptor Function and Embryonic Growth but Not Prostaglandin E2 Synthesis Mol. Cell. Biol., June 15, 2007; 27(12): 4416 - 4430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sanchez-Alavez and T. Bartfai It all happens between Toll receptors and Caspase 1 PNAS, May 8, 2007; 104(19): 7733 - 7734. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Francois, C. Facemire, A. Kumar, L. Audoly, B. Koller, and T. Coffman Role of Microsomal Prostaglandin E Synthase 1 in the Kidney J. Am. Soc. Nephrol., May 1, 2007; 18(5): 1466 - 1475. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Woolard, J. E. Wilson, L. L. Hensley, L. A. Jania, T. H. Kawula, J. R. Drake, and J. A. Frelinger Francisella tularensis-Infected Macrophages Release Prostaglandin E2 that Blocks T Cell Proliferation and Promotes a Th2-Like Response J. Immunol., February 15, 2007; 178(4): 2065 - 2074. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kapoor, F. Kojima, M. Qian, L. Yang, and L. J. Crofford Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase-1 null embryo fibroblasts: regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis FASEB J, November 1, 2006; 20(13): 2387 - 2389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chang, H. Hanawa, H. Liu, T. Yoshida, M. Hayashi, R. Watanabe, S. Abe, K. Toba, K. Yoshida, R. Elnaggar, et al. Hydrodynamic-Based Delivery of an Interleukin-22-Ig Fusion Gene Ameliorates Experimental Autoimmune Myocarditis in Rats J. Immunol., September 15, 2006; 177(6): 3635 - 3643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shibata, J. Gabbard, M. Yamashita, S. Tsuji, M. Smith, A. Nishiyama, R. A. Henriksen, and Q. N. Myrvik Heat-killed BCG induces biphasic cyclooxygenase 2+ splenic macrophage formation--role of IL-10 and bone marrow precursors J. Leukoc. Biol., September 1, 2006; 80(3): 590 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inada, C. Matsumoto, S. Uematsu, S. Akira, and C. Miyaura Membrane-Bound Prostaglandin E Synthase-1-Mediated Prostaglandin E2 Production by Osteoblast Plays a Critical Role in Lipopolysaccharide-Induced Bone Loss Associated with Inflammation J. Immunol., August 1, 2006; 177(3): 1879 - 1885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ikeda-Matsuo, A. Ota, T. Fukada, S. Uematsu, S. Akira, and Y. Sasaki Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury PNAS, August 1, 2006; 103(31): 11790 - 11795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. K. Lovgren, L. A. Jania, J. M. Hartney, K. K. Parsons, L. P. Audoly, G. A. FitzGerald, S. L. Tilley, and B. H. Koller COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis Am J Physiol Lung Cell Mol Physiol, August 1, 2006; 291(2): L144 - L156. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Cong, H.-L. Diao, Y.-C. Zhao, H. Ni, Y.-Q. Yan, and Z.-M. Yang Differential expression and regulation of cylooxygenases, prostaglandin E synthases and prostacyclin synthase in rat uterus during the peri-implantation period Reproduction, January 1, 2006; 131(1): 139 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Herath, D. P. Fischer, D. Werling, E. J. Williams, S. T. Lilly, H. Dobson, C. E. Bryant, and I. M. Sheldon Expression and Function of Toll-Like Receptor 4 in the Endometrial Cells of the Uterus Endocrinology, January 1, 2006; 147(1): 562 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Neild, S. Shin, and C. R. Roy Activated Macrophages Infected with Legionella Inhibit T Cells by Means of MyD88-Dependent Production of Prostaglandins J. Immunol., December 15, 2005; 175(12): 8181 - 8190. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kubota, T. Kubota, D. Kamei, M. Murakami, I. Kudo, T. Aso, and I. Morita Change in prostaglandin E synthases (PGESs) in microsomal PGES-1 knockout mice in a preterm delivery model J. Endocrinol., December 1, 2005; 187(3): 339 - 345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chandrasekharan, N. A. Foley, L. Jania, P. Clark, L. P. Audoly, and B. H. Koller Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland J. Lipid Res., December 1, 2005; 46(12): 2636 - 2648. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Shibata, R. A. Henriksen, I. Honda, R. M. Nakamura, and Q. N. Myrvik Splenic PGE2-releasing macrophages regulate Th1 and Th2 immune responses in mice treated with heat-killed BCG J. Leukoc. Biol., December 1, 2005; 78(6): 1281 - 1290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. E. Ackerman IV, J. M. Robinson, and D. A. Kniss Despite Transcriptional and Functional Coordination, Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Largely Reside in Distinct Lipid Microdomains in WISH Epithelial Cells J. Histochem. Cytochem., November 1, 2005; 53(11): 1391 - 1401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Masse, S. Guiral, L.-J. Fortin, E. Cauchon, D. Ethier, J. Guay, and C. Brideau An Automated Multistep High-Throughput Screening Assay for the Identification of Lead Inhibitors of the Inducible Enzyme mPGES-1 J Biomol Screen, September 1, 2005; 10(6): 599 - 605. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Sapirstein, H. Saito, S. J. Texel, T. A. Samad, E. O'Leary, and J. V. Bonventre Cytosolic phospholipase A2{alpha} regulates induction of brain cyclooxygenase-2 in a mouse model of inflammation Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1774 - R1782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Romanovsky Vioxx, Celebrex, Bextra....Do we have a new target for anti-inflammatory and antipyretic therapy? Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1098 - R1099. [Full Text] [PDF]
|
|
|
|
|
|
C. E. Trebino, J. D. Eskra, T. S. Wachtmann, J. R. Perez, T. J. Carty, and L. P. Audoly Redirection of Eicosanoid Metabolism in mPGES-1-deficient Macrophages J. Biol. Chem., April 29, 2005; 280(17): 16579 - 16585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Rowley, C. L. Vogan, G. W. Taylor, and A. S. Clare Prostaglandins in non-insectan invertebrates: recent insights and unsolved problems J. Exp. Biol., January 1, 2005; 208(1): 3 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Giannico, M. Mendez, and M. C. LaPointe Regulation of the membrane-localized prostaglandin E synthases mPGES-1 and mPGES-2 in cardiac myocytes and fibroblasts Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H165 - H174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Rouzer, P. J. Kingsley, H. Wang, H. Zhang, J. D. Morrow, S. K. Dey, and L. J. Marnett Cyclooxygenase-1-dependent Prostaglandin Synthesis Modulates Tumor Necrosis Factor-{alpha} Secretion in Lipopolysaccharide-challenged Murine Resident Peritoneal Macrophages J. Biol. Chem., August 13, 2004; 279(33): 34256 - 34268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kamei, K. Yamakawa, Y. Takegoshi, M. Mikami-Nakanishi, Y. Nakatani, S. Oh-ishi, H. Yasui, Y. Azuma, N. Hirasawa, K. Ohuchi, et al. Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1 J. Biol. Chem., August 6, 2004; 279(32): 33684 - 33695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Bafica, C. A. Scanga, M. Schito, D. Chaussabel, and A. Sher Influence of Coinfecting Pathogens on HIV Expression: Evidence for a Role of Toll-Like Receptors J. Immunol., June 15, 2004; 172(12): 7229 - 7234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Guay, K. Bateman, R. Gordon, J. Mancini, and D. Riendeau Carrageenan-induced Paw Edema in Rat Elicits a Predominant Prostaglandin E2 (PGE2) Response in the Central Nervous System Associated with the Induction of Microsomal PGE2 Synthase-1 J. Biol. Chem., June 4, 2004; 279(23): 24866 - 24872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Boulet, M. Ouellet, K. P. Bateman, D. Ethier, M. D. Percival, D. Riendeau, J. A. Mancini, and N. Methot Deletion of Microsomal Prostaglandin E2 (PGE2) Synthase-1 Reduces Inducible and Basal PGE2 Production and Alters the Gastric Prostanoid Profile J. Biol. Chem., May 28, 2004; 279(22): 23229 - 23237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Cheng, H. Afif, J. Martel-Pelletier, J.-P. Pelletier, X. Li, K. Farrajota, M. Lavigne, and H. Fahmi Activation of Peroxisome Proliferator-activated Receptor {gamma} Inhibits Interleukin-1{beta}-induced Membrane-associated Prostaglandin E2 Synthase-1 Expression in Human Synovial Fibroblasts by Interfering with Egr-1 J. Biol. Chem., May 21, 2004; 279(21): 22057 - 22065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-K. Lim, Y.-A. Choi, W. Park, T. Lee, S. H. Ryu, S.-Y. Kim, J.-R. Kim, J.-H. Kim, and S.-H. Baek Phosphatidic Acid Regulates Systemic Inflammatory Responses by Modulating the Akt-Mammalian Target of Rapamycin-p70 S6 Kinase 1 Pathway J. Biol. Chem., November 14, 2003; 278(46): 45117 - 45127. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Murakami, K. Nakashima, D. Kamei, S. Masuda, Y. Ishikawa, T. Ishii, Y. Ohmiya, K. Watanabe, and I. Kudo Cellular Prostaglandin E2 Production by Membrane-bound Prostaglandin E Synthase-2 via Both Cyclooxygenases-1 and -2 J. Biol. Chem., September 26, 2003; 278(39): 37937 - 37947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. N. Serhan and B. Levy Success of prostaglandin E2 in structure-function is a challenge for structure-based therapeutics PNAS, July 22, 2003; 100(15): 8609 - 8611. [Full Text] [PDF]
|
|
|
|
|
|
C. E. Trebino, J. L. Stock, C. P. Gibbons, B. M. Naiman, T. S. Wachtmann, J. P. Umland, K. Pandher, J.-M. Lapointe, S. Saha, M. L. Roach, et al. Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase PNAS, July 22, 2003; 100(15): 9044 - 9049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Kamei, M. Murakami, Y. Nakatani, Y. Ishikawa, T. Ishii, and I. Kudo Potential Role of Microsomal Prostaglandin E Synthase-1 in Tumorigenesis J. Biol. Chem., May 23, 2003; 278(21): 19396 - 19405. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Miyaura, M. Inada, C. Matsumoto, T. Ohshiba, N. Uozumi, T. Shimizu, and A. Ito An Essential Role of Cytosolic Phospholipase A2{alpha} in Prostaglandin E2-mediated Bone Resorption Associated with Inflammation J. Exp. Med., May 19, 2003; 197(10): 1303 - 1310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Claveau, M. Sirinyan, J. Guay, R. Gordon, C.-C. Chan, Y. Bureau, D. Riendeau, and J. A. Mancini Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model J. Immunol., May 1, 2003; 170(9): 4738 - 4744. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
