The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parham, C.
Right arrow Articles by Moore, K. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parham, C.
Right arrow Articles by Moore, K. W.
The Journal of Immunology, 2002, 168: 5699-5708.
Copyright © 2002 by The American Association of Immunologists

A Receptor for the Heterodimeric Cytokine IL-23 Is Composed of IL-12R{beta}1 and a Novel Cytokine Receptor Subunit, IL-23R1

Christi Parham2,3,*, Madaline Chirica2,*, Jacqueline Timans{dagger}, Elena Vaisberg*, Marilyn Travis*, Jeanne Cheung*, Stefan Pflanz{dagger}, Rebecca Zhang{dagger}, Komal P. Singh*, Felix Vega{dagger}, Wayne To{dagger}, Janet Wagner{dagger}, Anne-Marie O’Farrell4,*, Terrill McClanahan{ddagger}, Sandra Zurawski{dagger}, Charles Hannum{dagger}, Daniel Gorman{dagger}, Donna M. Rennick*, Robert A. Kastelein{dagger}, Rene de Waal Malefyt* and Kevin W. Moore5,*

Departments of * Immunology, {dagger} Molecular Biology, and {ddagger} Molecular Pathology, DNAX Research, Palo Alto, CA 94304

IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related to IL-12p35, termed p19. Human and mouse IL-23 exhibit some activities similar to IL-12, but differ in their capacities to stimulate particular populations of memory T cells. Like IL-12, IL-23 binds to the IL-12R subunit IL-12R{beta}1. However, it does not use IL-12R{beta}2. In this study, we identify a novel member of the hemopoietin receptor family as a subunit of the receptor for IL-23, "IL-23R." IL-23R pairs with IL-12R{beta}1 to confer IL-23 responsiveness on cells expressing both subunits. Human IL-23, but not IL-12, exhibits detectable affinity for human IL-23R. Anti-IL-12R{beta}1 and anti-IL-23R Abs block IL-23 responses of an NK cell line and Ba/F3 cells expressing the two receptor chains. IL-23 activates the same Jak-stat signaling molecules as IL-12: Jak2, Tyk2, and stat1, -3, -4, and -5, but stat4 activation is substantially weaker and different DNA-binding stat complexes form in response to IL-23 compared with IL-12. IL-23R associates constitutively with Jak2 and in a ligand-dependent manner with stat3. The ability of cells to respond to IL-23 or IL-12 correlates with expression of IL-23R or IL-12R{beta}2, respectively. The human IL-23R gene is on human chromosome 1 within 150 kb of IL-12R{beta}2.




This article has been cited by other articles:


Home page
 J. Exp. Med.Home page
C. S. Ma, G. Y.J. Chew, N. Simpson, A. Priyadarshi, M. Wong, B. Grimbacher, D. A. Fulcher, S. G. Tangye, and M. C. Cook
Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3
J. Exp. Med., July 7, 2008; 205(7): 1551 - 1557.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D.-J. Kim, J.-I. Youn, S.-H. Seo, H.-T. Jin, and Y.-C. Sung
Differential Regulation of Antigen-Specific CD8+ T Cell Responses by IL-12p40 in a Dose-Dependent Manner
J. Immunol., June 1, 2008; 180(11): 7167 - 7174.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Muhlbauer, P. M. Chilton, T. C. Mitchell, and C. Jobin
Impaired Bcl3 Up-regulation Leads to Enhanced Lipopolysaccharide-induced Interleukin (IL)-23P19 Gene Expression in IL-10-/- Mice
J. Biol. Chem., May 23, 2008; 283(21): 14182 - 14189.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. V. Rachitskaya, A. M. Hansen, R. Horai, Z. Li, R. Villasmil, D. Luger, R. B. Nussenblatt, and R. R. Caspi
Cutting Edge: NKT Cells Constitutively Express IL-23 Receptor and ROR{gamma}t and Rapidly Produce IL-17 upon Receptor Ligation in an IL-6-Independent Fashion
J. Immunol., April 15, 2008; 180(8): 5167 - 5171.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. F. Y. Cheung, C. K. Wong, and C. W. K. Lam
Molecular Mechanisms of Cytokine and Chemokine Release from Eosinophils Activated by IL-17A, IL-17F, and IL-23: Implication for Th17 Lymphocytes-Mediated Allergic Inflammation
J. Immunol., April 15, 2008; 180(8): 5625 - 5635.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Tanaka, K. Ichiyama, M. Hashimoto, H. Yoshida, T. Takimoto, G. Takaesu, T. Torisu, T. Hanada, H. Yasukawa, S. Fukuyama, et al.
Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-{gamma} on STAT3 and Smads
J. Immunol., March 15, 2008; 180(6): 3746 - 3756.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. K. Huber, E. M. Jacobson, K. Jazdzewski, E. S. Concepcion, and Y. Tomer
Interleukin (IL)-23 Receptor Is a Major Susceptibility Gene for Graves' Ophthalmopathy: The IL-23/T-helper 17 Axis Extends to Thyroid Autoimmunity
J. Clin. Endocrinol. Metab., March 1, 2008; 93(3): 1077 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. E. Ruby, R. Montler, R. Zheng, S. Shu, and A. D. Weinberg
IL-12 Is Required for Anti-OX40-Mediated CD4 T Cell Survival
J. Immunol., February 15, 2008; 180(4): 2140 - 2148.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Fukata, K. Breglio, A. Chen, A. S. Vamadevan, T. Goo, D. Hsu, D. Conduah, R. Xu, and M. T. Abreu
The Myeloid Differentiation Factor 88 (MyD88) Is Required for CD4+ T Cell Effector Function in a Murine Model of Inflammatory Bowel Disease
J. Immunol., February 1, 2008; 180(3): 1886 - 1894.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Mise-Omata, E. Kuroda, J. Niikura, U. Yamashita, Y. Obata, and T. S. Doi
A Proximal {kappa}B Site in the IL-23 p19 Promoter Is Responsible for RelA- and c-Rel-Dependent Transcription
J. Immunol., November 15, 2007; 179(10): 6596 - 6603.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Rider, A. Shatrova, E. P. Feener, L. Webb, and M. Diakonova
JAK2 Tyrosine Kinase Phosphorylates PAK1 and Regulates PAK1 Activity and Functions
J. Biol. Chem., October 19, 2007; 282(42): 30985 - 30996.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Kohyama, S. Ohno, A. Isoda, O. Moriya, M. L. Belladonna, H. Hayashi, Y. Iwakura, T. Yoshimoto, T. Akatsuka, and M. Matsui
IL-23 Enhances Host Defense against Vaccinia Virus Infection Via a Mechanism Partly Involving IL-17
J. Immunol., September 15, 2007; 179(6): 3917 - 3925.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
F.-L. Liu, C.-H. Chen, S.-J. Chu, J.-H. Chen, J.-H. Lai, H.-K. Sytwu, and D.-M. Chang
Interleukin (IL)-23 p19 expression induced by IL-1{beta} in human fibroblast-like synoviocytes with rheumatoid arthritis via active nuclear factor-{kappa}B and AP-1 dependent pathway
Rheumatology, August 1, 2007; 46(8): 1266 - 1273.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Tokumasa, A. Suto, S.-i. Kagami, S. Furuta, K. Hirose, N. Watanabe, Y. Saito, K. Shimoda, I. Iwamoto, and H. Nakajima
Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-{gamma} production and the induction of Th1 cell differentiation
Blood, July 15, 2007; 110(2): 553 - 560.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Kaiga, M. Sato, H. Kaneda, Y. Iwakura, T. Takayama, and H. Tahara
Systemic Administration of IL-23 Induces Potent Antitumor Immunity Primarily Mediated through Th1-Type Response in Association with the Endogenously Expressed IL-12
J. Immunol., June 15, 2007; 178(12): 7571 - 7580.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
X. L. Rudner, K. I. Happel, E. A. Young, and J. E. Shellito
Interleukin-23 (IL-23)-IL-17 Cytokine Axis in Murine Pneumocystis carinii Infection
Infect. Immun., June 1, 2007; 75(6): 3055 - 3061.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. N. Mathur, H.-C. Chang, D. G. Zisoulis, G. L. Stritesky, Q. Yu, J. T. O'Malley, R. Kapur, D. E. Levy, G. S. Kansas, and M. H. Kaplan
Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells
J. Immunol., April 15, 2007; 178(8): 4901 - 4907.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
I. D. Jung, J. S. Lee, Y. J. Kim, Y.-I. Jeong, C.-M. Lee, T. Baumruker, A. Billlich, Y. Banno, M. G. Lee, S.-C. Ahn, et al.
Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells
Int. Immunol., April 1, 2007; 19(4): 411 - 426.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. O. Yang, A. D. Panopoulos, R. Nurieva, S. H. Chang, D. Wang, S. S. Watowich, and C. Dong
STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells
J. Biol. Chem., March 30, 2007; 282(13): 9358 - 9363.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. M. Hildner, P. Schirmacher, I. Atreya, M. Dittmayer, B. Bartsch, P. R. Galle, S. Wirtz, and M. F. Neurath
Targeting of the Transcription Factor STAT4 by Antisense Phosphorothioate Oligonucleotides Suppresses Collagen-Induced Arthritis
J. Immunol., March 15, 2007; 178(6): 3427 - 3436.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Umemura, A. Yahagi, S. Hamada, M. D. Begum, H. Watanabe, K. Kawakami, T. Suda, K. Sudo, S. Nakae, Y. Iwakura, et al.
IL-17-Mediated Regulation of Innate and Acquired Immune Response against Pulmonary Mycobacterium bovis Bacille Calmette-Guerin Infection
J. Immunol., March 15, 2007; 178(6): 3786 - 3796.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. M. Wozniak, A. A. Ryan, and W. J. Britton
Interleukin-23 Restores Immunity to Mycobacterium tuberculosis Infection in IL-12p40-Deficient Mice and Is Not Required for the Development of IL-17-Secreting T Cell Responses
J. Immunol., December 15, 2006; 177(12): 8684 - 8692.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
R. H. Duerr, K. D. Taylor, S. R. Brant, J. D. Rioux, M. S. Silverberg, M. J. Daly, A. H. Steinhart, C. Abraham, M. Regueiro, A. Griffiths, et al.
A Genome-Wide Association Study Identifies IL23R as an Inflammatory Bowel Disease Gene
Science, December 1, 2006; 314(5804): 1461 - 1463.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
J. R. Chan, W. Blumenschein, E. Murphy, C. Diveu, M. Wiekowski, S. Abbondanzo, L. Lucian, R. Geissler, S. Brodie, A. B. Kimball, et al.
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis
J. Exp. Med., November 27, 2006; 203(12): 2577 - 2587.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. C. Kullberg, D. Jankovic, C. G. Feng, S. Hue, P. L. Gorelick, B. S. McKenzie, D. J. Cua, F. Powrie, A. W. Cheever, K. J. Maloy, et al.
IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
J. Exp. Med., October 30, 2006; 203(11): 2485 - 2494.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. N. Mathur, H.-C. Chang, D. G. Zisoulis, R. Kapur, M. L. Belladonna, G. S. Kansas, and M. H. Kaplan
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype
Blood, September 1, 2006; 108(5): 1595 - 1601.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Li, N. Chu, A. Rostami, and G.-X. Zhang
Dendritic Cells Transduced with SOCS-3 Exhibit a Tolerogenic/DC2 Phenotype That Directs Type 2 Th Cell Differentiation In Vitro and In Vivo
J. Immunol., August 1, 2006; 177(3): 1679 - 1688.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. J. Fahey, R. A. Robins, K. B. Kindle, D. M. Heery, and C. S. Constantinescu
Effects of glucocorticoids on STAT4 activation in human T cells are stimulus-dependent
J. Leukoc. Biol., July 1, 2006; 80(1): 133 - 144.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Oniki, H. Nagai, T. Horikawa, J. Furukawa, M. L. Belladonna, T. Yoshimoto, I. Hara, and C. Nishigori
Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma.
Cancer Res., June 15, 2006; 66(12): 6395 - 6404.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Z. Chen, A. Laurence, Y. Kanno, M. Pacher-Zavisin, B.-M. Zhu, C. Tato, A. Yoshimura, L. Hennighausen, and J. J. O'Shea
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
PNAS, May 23, 2006; 103(21): 8137 - 8142.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. W. Overwijk, K. E. de Visser, F. H. Tirion, L. A. de Jong, T. W. H. Pols, Y. U. van der Velden, J. G. van den Boorn, A. M. Keller, W. A. Buurman, M. R. Theoret, et al.
Immunological and Antitumor Effects of IL-23 as a Cancer Vaccine Adjuvant
J. Immunol., May 1, 2006; 176(9): 5213 - 5222.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M.-L. Cho, J.-W. Kang, Y.-M. Moon, H.-J. Nam, J.-Y. Jhun, S.-B. Heo, H.-T. Jin, S.-Y. Min, J.-H. Ju, K.-S. Park, et al.
STAT3 and NF-{kappa}B Signal Pathway Is Required for IL-23-Mediated IL-17 Production in Spontaneous Arthritis Animal Model IL-1 Receptor Antagonist-Deficient Mice
J. Immunol., May 1, 2006; 176(9): 5652 - 5661.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
M. O Huising, C. P Kruiswijk, and G. Flik
Phylogeny and evolution of class-I helical cytokines.
J. Endocrinol., April 1, 2006; 189(1): 1 - 25.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Lai, R. A. Zeff, and I. Goldschneider
A recombinant single-chain IL-7/HGFbeta hybrid cytokine induces juxtacrine interactions of the IL-7 and HGF (c-Met) receptors and stimulates the proliferation of CFU-S12, CLPs, and pre-pro-B cells
Blood, March 1, 2006; 107(5): 1776 - 1784.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. A. Kleinschek, U. Muller, S. J. Brodie, W. Stenzel, G. Kohler, W. M. Blumenschein, R. K. Straubinger, T. McClanahan, R. A. Kastelein, and G. Alber
IL-23 Enhances the Inflammatory Cell Response in Cryptococcus neoformans Infection and Induces a Cytokine Pattern Distinct from IL-12
J. Immunol., January 15, 2006; 176(2): 1098 - 1106.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. M. Wozniak, A. A. Ryan, J. A. Triccas, and W. J. Britton
Plasmid Interleukin-23 (IL-23), but Not Plasmid IL-27, Enhances the Protective Efficacy of a DNA Vaccine against Mycobacterium tuberculosis Infection
Infect. Immun., January 1, 2006; 74(1): 557 - 565.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Kidoya, M. Umemura, T. Kawabe, G. Matsuzaki, A. Yahagi, R. Imamura, and T. Suda
Fas Ligand Induces Cell-Autonomous IL-23 Production in Dendritic Cells, a Mechanism for Fas Ligand-Induced IL-17 Production
J. Immunol., December 15, 2005; 175(12): 8024 - 8031.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. L. Drakes, T. G. Blanchard, and S. J. Czinn
Colon lamina propria dendritic cells induce a proinflammatory cytokine response in lamina propria T cells in the SCID mouse model of colitis
J. Leukoc. Biol., December 1, 2005; 78(6): 1291 - 1300.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
K. I. Happel, P. J. Dubin, M. Zheng, N. Ghilardi, C. Lockhart, L. J. Quinton, A. R. Odden, J. E. Shellito, G. J. Bagby, S. Nelson, et al.
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
J. Exp. Med., September 19, 2005; 202(6): 761 - 769.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. I. Rutitzky, J. R. Lopes da Rosa, and M. J. Stadecker
Severe CD4 T Cell-Mediated Immunopathology in Murine Schistosomiasis Is Dependent on IL-12p40 and Correlates with High Levels of IL-17
J. Immunol., September 15, 2005; 175(6): 3920 - 3926.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. I. Happel, E. A. Lockhart, C. M. Mason, E. Porretta, E. Keoshkerian, A. R. Odden, S. Nelson, and A. J. Ramsay
Pulmonary Interleukin-23 Gene Delivery Increases Local T-Cell Immunity and Controls Growth of Mycobacterium tuberculosis in the Lungs
Infect. Immun., September 1, 2005; 73(9): 5782 - 5788.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. A. Khader, J. E. Pearl, K. Sakamoto, L. Gilmartin, G. K. Bell, D. M. Jelley-Gibbs, N. Ghilardi, F. deSauvage, and A. M. Cooper
IL-23 Compensates for the Absence of IL-12p70 and Is Essential for the IL-17 Response during Tuberculosis but Is Dispensable for Protection and Antigen-Specific IFN-{gamma} Responses if IL-12p70 Is Available
J. Immunol., July 15, 2005; 175(2): 788 - 795.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
N. Schuetze, S. Schoeneberger, U. Mueller, M. A. Freudenberg, G. Alber, and R. K. Straubinger
IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella Enteritidis and the impact of IL-10 in bone marrow-derived macrophages
Int. Immunol., May 1, 2005; 17(5): 649 - 659.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Arsenescu, A. M. Blum, A. Metwali, D. E. Elliott, and J. V. Weinstock
IL-12 Induction of mRNA Encoding Substance P in Murine Macrophages from the Spleen and Sites of Inflammation
J. Immunol., April 1, 2005; 174(7): 3906 - 3911.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Schnurr, T. Toy, A. Shin, M. Wagner, J. Cebon, and E. Maraskovsky
Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway
Blood, February 15, 2005; 105(4): 1582 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
E. Bettelli and V. K. Kuchroo
IL-12- and IL-23-induced T helper cell subsets: birds of the same feather flock together
J. Exp. Med., January 18, 2005; 201(2): 169 - 171.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Sun, M. Walsh, A. V. Villarino, L. Cervi, C. A. Hunter, Y. Choi, and E. J. Pearce
TLR Ligands Can Activate Dendritic Cells to Provide a MyD88-Dependent Negative Signal for Th2 Cell Development
J. Immunol., January 15, 2005; 174(2): 742 - 751.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Fairweather, S. Frisancho-Kiss, S. A. Yusung, M. A. Barrett, S. E. Davis, R. A. Steele, S. J. L. Gatewood, and N. R. Rose
IL-12 Protects against Coxsackievirus B3-Induced Myocarditis by Increasing IFN-{gamma} and Macrophage and Neutrophil Populations in the Heart
J. Immunol., January 1, 2005; 174(1): 261 - 269.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Salcedo, J. K. Stauffer, E. Lincoln, T. C. Back, J. A. Hixon, C. Hahn, K. Shafer-Weaver, A. Malyguine, R. Kastelein, and J. M. Wigginton
IL-27 Mediates Complete Regression of Orthotopic Primary and Metastatic Murine Neuroblastoma Tumors: Role for CD8+ T Cells
J. Immunol., December 15, 2004; 173(12): 7170 - 7182.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J J O'Shea
Targeting the Jak/STAT pathway for immunosuppression
Ann Rheum Dis, November 1, 2004; 63(suppl_2): ii67 - ii71.
[Full Text] [PDF]

Home page
 BloodHome page
C. Fieschi, M. Bosticardo, L. de Beaucoudrey, S. Boisson-Dupuis, J. Feinberg, O. F. Santos, J. Bustamante, J. Levy, F. Candotti, and J.-L. Casanova
A novel form of complete IL-12/IL-23 receptor {beta}1 deficiency with cell surface-expressed nonfunctional receptors
Blood, October 1, 2004; 104(7): 2095 - 2101.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Morinobu, Y. Kanno, and J. J. O'Shea
Discrete Roles for Histone Acetylation in Human T Helper 1 Cell-specific Gene Expression
J. Biol. Chem., September 24, 2004; 279(39): 40640 - 40646.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S.-Z. Wang, Y.-X. Bao, C. L. Rosenberger, Y. Tesfaigzi, J. M. Stark, and K. S. Harrod
IL-12p40 and IL-18 Modulate Inflammatory and Immune Responses to Respiratory Syncytial Virus Infection
J. Immunol., September 15, 2004; 173(6): 4040 - 4049.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Matsui, O. Moriya, M. L. Belladonna, S. Kamiya, F. A. Lemonnier, T. Yoshimoto, and T. Akatsuka
Adjuvant Activities of Novel Cytokines, Interleukin-23 (IL-23) and IL-27, for Induction of Hepatitis C Virus-Specific Cytotoxic T Lymphocytes in HLA-A*0201 Transgenic Mice
J. Virol., September 1, 2004; 78(17): 9093 - 9104.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
J. Siren, T. Sareneva, J. Pirhonen, M. Strengell, V. Veckman, I. Julkunen, and S. Matikainen
Cytokine and contact-dependent activation of natural killer cells by influenza A or Sendai virus-infected macrophages
J. Gen. Virol., August 1, 2004; 85(8): 2357 - 2364.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Wassink, P. L. Vieira, H. H. Smits, G. A. Kingsbury, A. J. Coyle, M. L. Kapsenberg, and E. A. Wierenga
ICOS Expression by Activated Human Th Cells Is Enhanced by IL-12 and IL-23: Increased ICOS Expression Enhances the Effector Function of Both Th1 and Th2 Cells
J. Immunol., August 1, 2004; 173(3): 1779 - 1786.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. A. Lieberman, F. Cardillo, A. M. Owyang, D. M. Rennick, D. J. Cua, R. A. Kastelein, and C. A. Hunter
IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-12
J. Immunol., August 1, 2004; 173(3): 1887 - 1893.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
L. S. Argetsinger, J.-L. K. Kouadio, H. Steen, A. Stensballe, O. N. Jensen, and C. Carter-Su
Autophosphorylation of JAK2 on Tyrosines 221 and 570 Regulates Its Activity
Mol. Cell. Biol., June 1, 2004; 24(11): 4955 - 4967.
[Abstract]