| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Division of Viral Immunology, Center for AIDS Research, Kumamoto University, Kumamoto, Japan
Previous studies of perforin expression and cytokine
production in subsets of peripheral human
CD45RA-CD8+ T cells with different CD28/CD27
phenotypes showed that
CD28+CD45RA-CD8+ and
CD27+CD45RA-CD8+ T cells have
characteristics of memory T cells, whereas
CD28-CD45RA-CD8+ and
CD27-CD45RA-CD8+ T cells
have characteristics of both memory and effector T cells. However, the
differentiation pathway from memory CD8+ T cells into
memory/effector CD8+ T cells has not been completely
clarified. We investigated this differentiation pathway using EBV- and
human CMV (HCMV)-specific CD8+ T cells. Three subsets of
CD45RA-CD8+ T cells were observed in both
total CD8+ T cells and EBV- or HCMV-specific
CD8+ T cells: CD27+CD28+,
CD27+CD28-, and
CD27-CD28-. A significant number of the
CD27-CD28+ subset was observed in total CD8 T
cells. However, this subset was barely detectable in EBV- or
HCMV-specific CD8+ T cells. Analysis of perforin expression
and cytotoxic activity in the first three subsets suggested the
following differentiation pathway:
CD27+CD28+CD45RA-
CD27+CD28-CD45RA-CD27-CD28-CD45RA-.
This was supported by the observation that the frequency of
CCR5+ cells and CCR7+ cells decreased during
this sequence. Analysis of CCR5 and CCR7 expression in the
CD27+CD28+ memory cell subset demonstrated the
presence of three CCR5/CCR7 populations:
CCR5-CCR7+,
CCR5+CCR7+, and
CCR5+CCR7-. These findings suggested the
following differentiation pathway:
CD27+CD28+CD45RA-
(CCR5-CCR7+CCR5+CCR7+CCR5+CCR7-)CD27+CD28-CD45RA-CD27-CD28-CD45RA-.
The presence of a CD27-CD28+ subset with a
CCR5+CCR7- phenotype implies a specialized
role for this subset in the differentiation of CD8+ T
cells.
This article has been cited by other articles:
|
|
 |
|
  S. Gupta, S. Agrawal, and S. Gollapudi Differential Effect of Human Herpesvirus 6A on Cell Division and Apoptosis among Naive and Central and Effector Memory CD4+ and CD8+ T-Cell Subsets J. Virol., June 1, 2009; 83(11): 5442 - 5450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nikolova, J.-D. Lelievre, M. Carriere, A. Bensussan, and Y. Levy Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets Blood, May 7, 2009; 113(19): 4556 - 4565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kondo and M. Takiguchi Human memory CCR4+CD8+ T cell subset has the ability to produce multiple cytokines Int. Immunol., May 1, 2009; 21(5): 523 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kondo, H. Takata, F. Matsuki, and M. Takiguchi Cutting Edge: Phenotypic Characterization and Differentiation of Human CD8+ T Cells Producing IL-17 J. Immunol., February 15, 2009; 182(4): 1794 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. E. Dahl, A. Berson, J. Lora, and M. Fuentes A Novel CCR5-Specific Pharmacodynamic Assay in Whole Blood Using Phosphoflow Cytometry Highlights Different Ligand-Dependent Responses but Similar Properties of Antagonists in CD8+ and CD4+ T Lymphocytes J. Pharmacol. Exp. Ther., December 1, 2008; 327(3): 926 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. DeBenedette, D. M. Calderhead, H. Ketteringham, A. H. Gamble, J. M. Horvatinovich, I. Y. Tcherepanova, C. A. Nicolette, and D. G. Healey Priming of a Novel Subset of CD28+ Rapidly Expanding High-Avidity Effector Memory CTL by Post Maturation Electroporation-CD40L Dendritic Cells Is IL-12 Dependent J. Immunol., October 15, 2008; 181(8): 5296 - 5305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Okada, T. Kondo, F. Matsuki, H. Takata, and M. Takiguchi Phenotypic classification of human CD4+ T cell subsets and their differentiation Int. Immunol., September 1, 2008; 20(9): 1189 - 1199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Walker, D. Haley, U. Petrausch, K. Floyd, W. Miller, N. Sanjuan, G. Alvord, B. A. Fox, and W. J. Urba Phenotype and Functional Characterization of Long-term gp100-Specific Memory CD8+ T Cells in Disease-Free Melanoma Patients Before and After Boosting Immunization Clin. Cancer Res., August 15, 2008; 14(16): 5270 - 5283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Winter, J. Moser, E. Kriehuber, C. Wiesner, R. Knobler, F. Trautinger, P. Bombosi, G. Stingl, P. Petzelbauer, A. Rot, et al. Down-Modulation of CXCR3 Surface Expression and Function in CD8+ T Cells from Cutaneous T Cell Lymphoma Patients J. Immunol., September 15, 2007; 179(6): 4272 - 4282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fann, J. M. Godlove, M. Catalfamo, W. H. Wood III, F. J. Chrest, N. Chun, L. Granger, R. Wersto, K. Madara, K. Becker, et al. Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8+ T-cell response Blood, November 15, 2006; 108(10): 3363 - 3370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takata and M. Takiguchi Three Memory Subsets of Human CD8+ T Cells Differently Expressing Three Cytolytic Effector Molecules J. Immunol., October 1, 2006; 177(7): 4330 - 4340. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kobayashi, T. Kondo, H. Takata, S. Yokota, and M. Takiguchi Functional and phenotypic analysis of human memory CD8+ T cells expressing CXCR3. J. Leukoc. Biol., August 1, 2006; 80(2): 320 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. R. Hadrup, J. Strindhall, T. Kollgaard, T. Seremet, B. Johansson, G. Pawelec, P. thor Straten, and A. Wikby Longitudinal Studies of Clonally Expanded CD8 T Cells Reveal a Repertoire Shrinkage Predicting Mortality and an Increased Number of Dysfunctional Cytomegalovirus-Specific T Cells in the Very Elderly J. Immunol., February 15, 2006; 176(4): 2645 - 2653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Fritsch, X. Shen, G. P. Sims, K. S. Hathcock, R. J. Hodes, and P. E. Lipsky Stepwise Differentiation of CD4 Memory T Cells Defined by Expression of CCR7 and CD27 J. Immunol., November 15, 2005; 175(10): 6489 - 6497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Willinger, T. Freeman, H. Hasegawa, A. J. McMichael, and M. F. C. Callan Molecular Signatures Distinguish Human Central Memory from Effector Memory CD8 T Cell Subsets J. Immunol., November 1, 2005; 175(9): 5895 - 5903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Ahn, H. Chung, D.-s. Lee, Y. S. Yu, and H. G. Yu CD8brightCD56+ T Cells Are Cytotoxic Effectors in Patients with Active Behcet's Uveitis J. Immunol., November 1, 2005; 175(9): 6133 - 6142. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fujiwara, H. Takata, S. Oka, H. Tomiyama, and M. Takiguchi Patterns of Cytokine Production in Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Human CD8+ T Cells after Stimulation with HIV-1-Infected CD4+ T Cells J. Virol., October 1, 2005; 79(19): 12536 - 12543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, M. Bleakley, and C. Yee IL-21 Influences the Frequency, Phenotype, and Affinity of the Antigen-Specific CD8 T Cell Response J. Immunol., August 15, 2005; 175(4): 2261 - 2269. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Wikby, F. Ferguson, R. Forsey, J. Thompson, J. Strindhall, S. Lofgren, B.-O. Nilsson, J. Ernerudh, G. Pawelec, and B. Johansson An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2005; 60(5): 556 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gough, M. Crittenden, U. Thanarajasingam, L. Sanchez-Perez, J. Thompson, D. Jevremovic, and R. Vile Gene Therapy to Manipulate Effector T Cell Trafficking to Tumors for Immunotherapy J. Immunol., May 1, 2005; 174(9): 5766 - 5773. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. W. van Deventer, W. O'Connor Jr., W. J. Brickey, R. M. Aris, J. P.Y. Ting, and J. S. Serody C-C Chemokine Receptor 5 on Stromal Cells Promotes Pulmonary Metastasis Cancer Res., April 15, 2005; 65(8): 3374 - 3379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sun, J. E. Schmitz, P. M. Acierno, S. Santra, R. A. Subbramanian, D. H. Barouch, D. A. Gorgone, M. A. Lifton, K. R. Beaudry, K. Manson, et al. Dysfunction of Simian Immunodeficiency Virus/Simian Human Immunodeficiency Virus-Induced IL-2 Expression by Central Memory CD4+ T Lymphocytes J. Immunol., April 15, 2005; 174(8): 4753 - 4760. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Fischer, S. Voelkl, J. Heymann, G. K. Przybylski, K. Mondal, M. Laumer, L. Kunz-Schughart, C. A. Schmidt, R. Andreesen, and A. Mackensen Isolation and characterization of human antigen-specific TCR{alpha}{beta}+ CD4-CD8- double-negative regulatory T cells Blood, April 1, 2005; 105(7): 2828 - 2835. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sabbaj, M. K. Ghosh, B. H. Edwards, R. Leeth, W. D. Decker, P. A. Goepfert, and G. M. Aldrovandi Breast Milk-Derived Antigen-Specific CD8+ T Cells: An Extralymphoid Effector Memory Cell Population in Humans J. Immunol., March 1, 2005; 174(5): 2951 - 2956. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Kolber Impact of Immune Plasticity on Development of Cellular Memory Responses to Human Immunodeficiency Virus Type 1 Clin. Vaccine Immunol., November 1, 2004; 11(6): 1002 - 1007. [Full Text] [PDF]
|
|
|
|
|
|
N. Meidenbauer, A. Zippelius, M. J. Pittet, M. Laumer, S. Vogl, J. Heymann, M. Rehli, B. Seliger, S. Schwarz, F.-A. L. Gal, et al. High Frequency of Functionally Active Melan-A-Specific T Cells in a Patient with Progressive Immunoproteasome-Deficient Melanoma Cancer Res., September 1, 2004; 64(17): 6319 - 6326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takata, H. Tomiyama, M. Fujiwara, N. Kobayashi, and M. Takiguchi Cutting Edge: Expression of Chemokine Receptor CXCR1 on Human Effector CD8+ T Cells J. Immunol., August 15, 2004; 173(4): 2231 - 2235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Wherry and R. Ahmed Memory CD8 T-Cell Differentiation during Viral Infection J. Virol., June 1, 2004; 78(11): 5535 - 5545. [Full Text] [PDF]
|
|
|
|
|
|
M. V. Maus, B. Kovacs, W. W. Kwok, G. T. Nepom, K. Schlienger, J. L. Riley, D. Allman, T. H. Finkel, and C. H. June Extensive Replicative Capacity of Human Central Memory T Cells J. Immunol., June 1, 2004; 172(11): 6675 - 6683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Umehara, E. T. Bloom, T. Okazaki, Y. Nagano, O. Yoshie, and T. Imai Fractalkine in Vascular Biology: From Basic Research to Clinical Disease Arterioscler Thromb Vasc Biol, January 1, 2004; 24(1): 34 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Amyes, C. Hatton, D. Montamat-Sicotte, N. Gudgeon, A. B. Rickinson, A. J. McMichael, and M. F.C. Callan Characterization of the CD4+ T Cell Response to Epstein-Barr Virus during Primary and Persistent Infection J. Exp. Med., September 15, 2003; 198(6): 903 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Salazar, C. D. Pope, T. J. Sellati, H. M. Feder Jr, T. G. Kiely, K. R. Dardick, R. L. Buckman, M. W. Moore, M. J. Caimano, J. G. Pope, et al. Coevolution of Markers of Innate and Adaptive Immunity in Skin and Peripheral Blood of Patients with Erythema Migrans J. Immunol., September 1, 2003; 171(5): 2660 - 2670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Rufer, A. Zippelius, P. Batard, M. J. Pittet, I. Kurth, P. Corthesy, J.-C. Cerottini, S. Leyvraz, E. Roosnek, M. Nabholz, et al. Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions Blood, September 1, 2003; 102(5): 1779 - 1787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sauce, N. Rufer, P. Mercier, M. Bodinier, J.-P. Remy-Martin, A. Duperrier, C. Ferrand, P. Herve, P. Romero, F. Lang, et al. Retrovirus-mediated gene transfer in polyclonal T cells results in lower apoptosis and enhanced ex vivo cell expansion of CMV-reactive CD8 T cells as compared with EBV-reactive CD8 T cells Blood, August 15, 2003; 102(4): 1241 - 1248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-M. Roger, J. Durant, M. Ticchioni, P. Halfon, J.-P. Breittmayer, C. Brignone, S. Chaillou, B. Dunais, P. Dellamonica, A. Bernard, et al. Apoptosis and proliferation kinetics of T cells in patients having experienced antiretroviral treatment interruptions J. Antimicrob. Chemother., August 1, 2003; 52(2): 269 - 275. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Strauss, I. Knape, I. Melzner, and K.-M. Debatin Constitutive Caspase Activation and Impaired Death-Inducing Signaling Complex Formation in CD95-Resistant, Long-Term Activated, Antigen-Specific T Cells J. Immunol., August 1, 2003; 171(3): 1172 - 1182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. M. Mackus, F. N. J. Frakking, A. Grummels, L. E. Gamadia, G. J. de Bree, D. Hamann, R. A. W. van Lier, and M. H. J. van Oers Expansion of CMV-specific CD8+CD45RA+CD27- T cells in B-cell chronic lymphocytic leukemia Blood, August 1, 2003; 102(3): 1057 - 1063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Moschella, B. Bisikirska, A. Maffei, K. P. Papadopoulos, D. Skerrett, Z. Liu, C. S. Hesdorffer, and P. E. Harris Gene Expression Profiling and Functional Activity of Human Dendritic Cells Induced with IFN-{alpha}-2b: Implications for Cancer Immunotherapy Clin. Cancer Res., June 1, 2003; 9(6): 2022 - 2031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Shacklett, C. A. Cox, J. K. Sandberg, N. H. Stollman, M. A. Jacobson, and D. F. Nixon Trafficking of Human Immunodeficiency Virus Type 1-Specific CD8+ T Cells to Gut-Associated Lymphoid Tissue during Chronic Infection J. Virol., May 15, 2003; 77(10): 5621 - 5631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Nascimbeni, E. Mizukoshi, M. Bosmann, M. E. Major, K. Mihalik, C. M. Rice, S. M. Feinstone, and B. Rehermann Kinetics of CD4+ and CD8+ Memory T-Cell Responses during Hepatitis C Virus Rechallenge of Previously Recovered Chimpanzees J. Virol., April 15, 2003; 77(8): 4781 - 4793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Aandahl, J. K. Sandberg, K. P. Beckerman, K. Tasken, W. J. Moretto, and D. F. Nixon CD7 Is a Differentiation Marker That Identifies Multiple CD8 T Cell Effector Subsets J. Immunol., March 1, 2003; 170(5): 2349 - 2355. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
