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in Macrophages from BALB/c Mice1
Department of Immunology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
BALB/c mice have been shown to easily induce Th2 type responses in
several infection models. In this study, to examine the mechanisms of
Th2 dominant responses in BALB/c mice, we assessed several macrophage
functions using C3H/HeN, C57BL/6, and BALB/c mouse strains. Peritoneal
macrophages from three strains of mice equally produced IL-12 by
stimulation with LPS plus IFN-
. However, IFN- production in
response to IL-12 or IL-12 plus IL-18 was much lower in macrophages
from BALB/c mice than other strains. IFN- produced by activated
macrophages induced IL-12R mRNA expression in T cells and macrophages
themselves depending on their amount of IFN-; namely, macrophages
from BALB/c mice induced lower expression of IL-12R. Intracellular
levels of STAT4 were much lower in macrophages from BALB/c mice.
However, other STATs, such as STAT1 or STAT6, were expressed similarly
in the three mouse strains. STAT4 and IFN- production by other cell
types such as T cells and B cells were equal in C3H/HeN and BALB/c
mice. These results indicate that macrophages from Th2-dominant BALB/c
mice have different functional characters compared with other mouse
strains; that is, STAT4 expression and IFN- production are reduced,
which is one of the causes to shift to Th2-type
responses.
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