| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Immunology and Rheumatology and Institut National de la Sante et de la Recherche Médicale Unité 403, Hôpital Edouard Herriot, Lyon, France; and
Schering-Plough Laboratory for Immunological Research, Dardilly, France
It remains to be clarified whether dendritic cells (DC) reach the rheumatoid arthritis (RA) synovium, considered an ectopic lymphoid organ, as mature cells or undergo local maturation. We characterized by immunohistochemistry the DC subsets and used tonsils as a control. Immature and mature DC were defined by CD1a and DC-lysosome-associated membrane protein/CD83 expression, respectively. Immature DC were mainly detected in the lining layer in RA synovium. Mature DC were exclusively detected in the lymphocytic infiltrates. The DC-lysosome-associated membrane protein/CD1a ratio was 1.1 in RA synovium and 5.3 in tonsils, suggesting the relative accumulation of immature DC in RA synovium. We then focused on the expression of CCL20/CCR6 and CCL19/CCR7, CCL21/CCR7 chemokine/receptor complex, which control immature and mature DC migration respectively. A close association was observed between CCL20-producing cells and CD1a+ cells, suggesting the contribution of CCL20 to CCR6+ cell homing. Conversely, CCL21 and CCL19 expression was only detected in perivascular infiltrates. The association among CCL19/21-producing cells, CCR7 expression, and mature DC accumulation is in line with the roles of these chemokines in mature CCR7+ DC homing to lymphocytic infiltrates. The role of DC in disease initiation and perpetuation makes chemokines involved in DC migration a potential therapeutic target.
This article has been cited by other articles:
|
|
 |
|
  A W T van Lieshout, R van der Voort, L W J Toonen, S F G van Helden, C G Figdor, P L C M van Riel, T R D J Radstake, and G J Adema Regulation of CXCL16 expression and secretion by myeloid cells is not altered in rheumatoid arthritis Ann Rheum Dis, June 1, 2009; 68(6): 1036 - 1043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Andre, D. F. Tough, S. Lacroix-Desmazes, S. V. Kaveri, and J. Bayry Surveillance of Antigen-Presenting Cells by CD4+CD25+ Regulatory T Cells in Autoimmunity: Immunopathogenesis and Therapeutic Implications Am. J. Pathol., May 1, 2009; 174(5): 1575 - 1587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. L. Lakey, T. G. Morgan, A. D. Rowan, J. D. Isaacs, T. E. Cawston, and C. M. U. Hilkens A novel paradigm for dendritic cells as effectors of cartilage destruction Rheumatology, May 1, 2009; 48(5): 502 - 507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Fletcher, N. Seach, J. J. Reiseger, T. E. Lowen, M. V. Hammett, H. S. Scott, and R. L. Boyd Reduced Thymic Aire Expression and Abnormal NF-{kappa}B2 Signaling in a Model of Systemic Autoimmunity J. Immunol., March 1, 2009; 182(5): 2690 - 2699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Tournadre and P Miossec Chemokines and dendritic cells in inflammatory myopathies Ann Rheum Dis, March 1, 2009; 68(3): 300 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Jongbloed, R. A. Benson, M. B. Nickdel, P. Garside, I. B. McInnes, and J. M. Brewer Plasmacytoid Dendritic Cells Regulate Breach of Self-Tolerance in Autoimmune Arthritis J. Immunol., January 15, 2009; 182(2): 963 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Lebre, S. L. Jongbloed, S. W. Tas, T. J.M. Smeets, I. B. McInnes, and P. P. Tak Rheumatoid Arthritis Synovium Contains Two Subsets of CD83-DC-LAMP- Dendritic Cells with Distinct Cytokine Profiles Am. J. Pathol., April 1, 2008; 172(4): 940 - 950. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Manzo, S. Bugatti, R. Caporali, R. Prevo, D. G. Jackson, M. Uguccioni, C. D. Buckley, C. Montecucco, and C. Pitzalis CCL21 Expression Pattern of Human Secondary Lymphoid Organ Stroma Is Conserved in Inflammatory Lesions with Lymphoid Neogenesis Am. J. Pathol., November 1, 2007; 171(5): 1549 - 1562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J G Walker, M J Ahern, M Coleman, H Weedon, V Papangelis, D Beroukas, P J Roberts-Thomson, and M D Smith Characterisation of a dendritic cell subset in synovial tissue which strongly expresses Jak/STAT transcription factors from patients with rheumatoid arthritis Ann Rheum Dis, August 1, 2007; 66(8): 992 - 999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Galili, K. Wigglesworth, and U. M. Abdel-Motal Intratumoral Injection of {alpha}-gal Glycolipids Induces Xenograft-Like Destruction and Conversion of Lesions into Endogenous Vaccines J. Immunol., April 1, 2007; 178(7): 4676 - 4687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Raine, P. Zaccone, P. Mastroeni, and A. Cooke Salmonella typhimurium Infection in Nonobese Diabetic Mice Generates Immunomodulatory Dendritic Cells Able to Prevent Type 1 Diabetes J. Immunol., August 15, 2006; 177(4): 2224 - 2233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Roelofs, W. C. Boelens, L. A. B. Joosten, S. Abdollahi-Roodsaz, J. Geurts, L. U. Wunderink, B. W. Schreurs, W. B. van den Berg, and T. R. D. J. Radstake Identification of Small Heat Shock Protein B8 (HSP22) as a Novel TLR4 Ligand and Potential Involvement in the Pathogenesis of Rheumatoid Arthritis. J. Immunol., June 1, 2006; 176(11): 7021 - 7027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P Middel, D Raddatz, B Gunawan, F Haller, and H-J Radzun Increased number of mature dendritic cells in Crohn's disease: evidence for a chemokine mediated retention mechanism Gut, February 1, 2006; 55(2): 220 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J G Walker, M J Ahern, M Coleman, H Weedon, V Papangelis, D Beroukas, P J Roberts-Thomson, and M D Smith Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis Ann Rheum Dis, February 1, 2006; 65(2): 149 - 156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T R D J Radstake, K C A M Nabbe, M H Wenink, M F Roelofs, A Oosterlaar, A W T van Lieshout, P Barrera, P L E M van Lent, and W B van den Berg Dendritic cells from patients with rheumatoid arthritis lack the interleukin 13 mediated increase of Fc{gamma}RII expression, which has clear functional consequences Ann Rheum Dis, December 1, 2005; 64(12): 1737 - 1743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T R D J Radstake, A W T van Lieshout, P L C M van Riel, W B van den Berg, and G J Adema Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis Ann Rheum Dis, November 1, 2005; 64(11): 1532 - 1538. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Schutyser, A. Richmond, and J. Van Damme Involvement of CC chemokine ligand 18 (CCL18) in normal and pathological processes J. Leukoc. Biol., July 1, 2005; 78(1): 14 - 26. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A W T van Lieshout, P Barrera, R L Smeets, G J Pesman, P L C M van Riel, W B van den Berg, and T R D J Radstake Inhibition of TNF{alpha} during maturation of dendritic cells results in the development of semi-mature cells: a potential mechanism for the beneficial effects of TNF{alpha} blockade in rheumatoid arthritis Ann Rheum Dis, March 1, 2005; 64(3): 408 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T R D J Radstake, R van der Voort, M ten Brummelhuis, M de Waal Malefijt, M Looman, C G Figdor, W B van den Berg, P Barrera, and G J Adema Increased expression of CCL18, CCL19, and CCL17 by dendritic cells from patients with rheumatoid arthritis, and regulation by Fc gamma receptors Ann Rheum Dis, March 1, 2005; 64(3): 359 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Cupedo and R. E. Mebius Cellular Interactions in Lymph Node Development J. Immunol., January 1, 2005; 174(1): 21 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. W. Park, Y. M. Kang, J. Butterfield, M. Detmar, J. J. Goronzy, and C. M. Weyand Thrombospondin 2 Functions as an Endogenous Regulator of Angiogenesis and Inflammation in Rheumatoid Arthritis Am. J. Pathol., December 1, 2004; 165(6): 2087 - 2098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T R D J Radstake, A B Blom, A W Sloetjes, E O F van Gorselen, G J Pesman, L Engelen, R Torensma, W B van den Berg, C G Figdor, P L E M van Lent, et al. Increased Fc{gamma}RII expression and aberrant tumour necrosis factor {alpha} production by mature dendritic cells from patients with active rheumatoid arthritis Ann Rheum Dis, December 1, 2004; 63(12): 1556 - 1563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J J Haringman, J Ludikhuize, and P P Tak Chemokines in joint disease: the key to inflammation? Ann Rheum Dis, October 1, 2004; 63(10): 1186 - 1194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Lande, E. Giacomini, B. Serafini, B. Rosicarelli, G. D. Sebastiani, G. Minisola, U. Tarantino, V. Riccieri, G. Valesini, and E. M. Coccia Characterization and Recruitment of Plasmacytoid Dendritic Cells in Synovial Fluid and Tissue of Patients with Chronic Inflammatory Arthritis J. Immunol., August 15, 2004; 173(4): 2815 - 2824. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Luft, E. Maraskovsky, M. Schnurr, K. Knebel, M. Kirsch, M. Gorner, R. Skoda, A. D. Ho, P. Nawroth, and A. Bierhaus Tuning the volume of the immune response: strength and persistence of stimulation determine migration and cytokine secretion of dendritic cells Blood, August 15, 2004; 104(4): 1066 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Van Krinks, M. K. Matyszak, and J. S. Hill Gaston Characterization of plasmacytoid dendritic cells in inflammatory arthritis synovial fluid Rheumatology, April 1, 2004; 43(4): 453 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Movassagh, A. Spatz, J. Davoust, S. Lebecque, P. Romero, M. Pittet, D. Rimoldi, D. Lienard, O. Gugerli, L. Ferradini, et al. Selective Accumulation of Mature DC-Lamp+ Dendritic Cells in Tumor Sites Is Associated with Efficient T-Cell-Mediated Antitumor Response and Control of Metastatic Dissemination in Melanoma Cancer Res., March 15, 2004; 64(6): 2192 - 2198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kobayashi, S. Miura, H. Nagata, Y. Tsuzuki, R. Hokari, T. Ogino, C. Watanabe, T. Azuma, and H. Ishii In situ demonstration of dendritic cell migration from rat intestine to mesenteric lymph nodes: relationships to maturation and role of chemokines J. Leukoc. Biol., March 1, 2004; 75(3): 434 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Page, A. Sattler, S. Kersten, A. Thiel, A. Radbruch, and P. Miossec Plasma Cell-Like Morphology of Th1-Cytokine-Producing Cells Associated with the Loss of CD3 Expression Am. J. Pathol., February 1, 2004; 164(2): 409 - 417. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Chomarat, C. Dantin, L. Bennett, J. Banchereau, and A. K. Palucka TNF Skews Monocyte Differentiation from Macrophages to Dendritic Cells J. Immunol., September 1, 2003; 171(5): 2262 - 2269. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. B. McInnes, B. P. Leung, M. Harnett, J. A. Gracie, F. Y. Liew, and W. Harnett A Novel Therapeutic Approach Targeting Articular Inflammation Using the Filarial Nematode-Derived Phosphorylcholine-Containing Glycoprotein ES-62 J. Immunol., August 15, 2003; 171(4): 2127 - 2133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Weninger, H. S. Carlsen, M. Goodarzi, F. Moazed, M. A. Crowley, E. S. Baekkevold, L. L. Cavanagh, and U. H. von Andrian Naive T Cell Recruitment to Nonlymphoid Tissues: A Role for Endothelium-Expressed CC Chemokine Ligand 21 in Autoimmune Disease and Lymphoid Neogenesis J. Immunol., May 1, 2003; 170(9): 4638 - 4648. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
