The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van Houwelingen, A. H.
Right arrow Articles by Nijkamp, F. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van Houwelingen, A. H.
Right arrow Articles by Nijkamp, F. P.
The Journal of Immunology, 2002, 168: 5297-5302.
Copyright © 2002 by The American Association of Immunologists

Mast Cell-Derived TNF-{alpha} Primes Sensory Nerve Endings in a Pulmonary Hypersensitivity Reaction

Anneke H. van Houwelingen1, Mirjam Kool, Saskia C. A. de Jager, Frank A. M. Redegeld, Dicky van Heuven-Nolsen, Aletta D. Kraneveld and Frans P. Nijkamp

Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

TNF-{alpha} is a cytokine associated with inflammatory diseases, including asthma. Increased levels of TNF-{alpha} were found in the bronchoalveolar lavage fluid of mice undergoing a dinitrofluorobenzene (DNFB)-induced non-IgE-mediated pulmonary hypersensitivity reaction. We report in this work that TNF-{alpha} increases the susceptibility of sensory neurons to dinitrobenzene sulfonic acid (DNS) and capsaicin, leading to a tracheal vascular hyperpermeability response in DNFB-sensitized and DNS-challenged mice. mAb against TNF-{alpha} or the TNFR1 inhibited this hyperpermeability response in DNFB-sensitized and DNS-challenged mice. Furthermore, the hyperpermeability response after DNS challenge was abolished in DNFB-sensitized mast cell-deficient WBB6F1-W/WV mice. These animals showed a remarked decrease of TNF-{alpha} bronchoalveolar lavage fluid levels after a single DNS challenge. The hyperpermeability response after DNS challenge was regained in mast cell-deficient mice after mast cell reconstitution. These findings indicate a prominent role for TNF-{alpha} and its TNFR1 in the DNFB-induced tracheal hyperpermeability response. We propose that a priming effect of mast cell-derived TNF-{alpha} on the sensory neurons could be the mechanism of action of TNF-{alpha} in the vascular hyperpermeability response in tracheas of mice undergoing a pulmonary hypersensitivity reaction.




This article has been cited by other articles:


Home page
 Eur Respir JHome page
S. Reuter, A. Heinz, M. Sieren, R. Wiewrodt, E. W. Gelfand, M. Stassen, R. Buhl, and C. Taube
Mast cell-derived tumour necrosis factor is essential for allergic airway disease
Eur. Respir. J., April 1, 2008; 31(4): 773 - 782.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M.-G. Lee, X. Dong, Q. Liu, K. N. Patel, O. H. Choi, B. Vonakis, and B. J. Undem
Agonists of the Mas-Related Gene (Mrgs) Orphan Receptors as Novel Mediators of Mast Cell-Sensory Nerve Interactions
J. Immunol., February 15, 2008; 180(4): 2251 - 2255.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
A. K. Farraj, E. Boykin, N. Haykal-Coates, S. H. Gavett, D. Doerfler, and M. Selgrade
Th2 Cytokines in Skin Draining Lymph Nodes and Serum IgE Do Not Predict Airway Hypersensitivity to Intranasal Isocyanate Exposure in Mice
Toxicol. Sci., November 1, 2007; 100(1): 99 - 108.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Kakurai, R. Monteforte, H. Suto, M. Tsai, S. Nakae, and S. J. Galli
Mast Cell-Derived Tumor Necrosis Factor Can Promote Nerve Fiber Elongation in the Skin during Contact Hypersensitivity in Mice
Am. J. Pathol., November 1, 2006; 169(5): 1713 - 1721.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Furuno, A. Ito, Y.-i. Koma, K. Watabe, H. Yokozaki, J. Bienenstock, M. Nakanishi, and Y. Kitamura
The Spermatogenic Ig Superfamily/Synaptic Cell Adhesion Molecule Mast-Cell Adhesion Molecule Promotes Interaction with Nerves
J. Immunol., June 1, 2005; 174(11): 6934 - 6942.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. D. Kraneveld, M. Kool, A. H. van Houwelingen, P. Roholl, A. Solomon, D. S. Postma, F. P. Nijkamp, and F. A. Redegeld
From The Cover: Elicitation of allergic asthma by immunoglobulin free light chains
PNAS, February 1, 2005; 102(5): 1578 - 1583.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
I. A. Yang, O. Holz, R. A. Jorres, H. Magnussen, S. J. Barton, S. Rodriguez, J. A. Cakebread, J. W. Holloway, and S. T. Holgate
Association of Tumor Necrosis Factor-{alpha} Polymorphisms and Ozone-induced Change in Lung Function
Am. J. Respir. Crit. Care Med., January 15, 2005; 171(2): 171 - 176.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
A. K. Farraj, J. R. Harkema, and N. E. Kaminski
Allergic Rhinitis Induced by Intranasal Sensitization and Challenge with Trimellitic Anhydride but Not with Dinitrochlorobenzene or Oxazolone in A/J Mice
Toxicol. Sci., June 1, 2004; 79(2): 315 - 325.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.