| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Modulates 4
7 Integrin-Mediated Lymphocyte Adhesion to Mucosal Addressin Cell Adhesion Molecule-1 and Fibronectin1
* Department of Immunology, Centro de Investigaciones Biológicas, and
Department of Immunology and Oncology, Centro Nacional de Biotecnología, Madrid, Spain; and
Millenium Pharmaceuticals, Inc., Cambridge, MA 02139
The interaction between the integrin
4
7 and its ligand, mucosal addressin cell
adhesion molecule-1, on high endothelial venules represents a key
adhesion event during lymphocyte homing to secondary lymphoid tissue.
Stromal cell-derived factor-1 (SDF-1) is a chemokine that
attracts T and B lymphocytes and has been hypothesized to be involved
in lymphocyte homing. In this work we show that
47-mediated adhesion of CD4+
T lymphocytes and the RPMI 8866 cell line to mucosal addressin cell
adhesion molecule-1 was up-regulated by SDF-1 in both static
adhesion and cell detachment under shear stress assays. Both naive and
memory phenotype CD4+ T cells were targets of
SDF-1-triggered increased adhesion. In addition, SDF-1 augmented
47-dependent adhesion of RPMI 8866 cells
to connecting segment-1 of fibronectin. While pertussis toxin totally
blocked chemotaxis of CD4+ and RPMI 8866 cells to SDF-1,
enhanced 47-dependent adhesion triggered
by this chemokine was partially inhibited, indicating the participation
of Gi-dependent as well as Gi-independent
signaling. Accordingly, we show that SDF-1 induced a rapid and
transient association between its receptor CXCR4 and Gi,
whereas association of pertussis toxin-insensitive G13
with CXCR4 was slower and of a lesser extent. SDF-1 also activated
the small GTPases RhoA and Rac1, and inhibition of RhoA activation
reduced the up-regulation of 47-mediated
lymphocyte adhesion in response to SDF-1, suggesting that activation
of RhoA could play an important role in the enhanced adhesion. These
data indicate that up-regulation by SDF-1 of lymphocyte adhesion
mediated by 47 could contribute to
lymphocyte homing to secondary lymphoid tissues.
This article has been cited by other articles:
|
|
 |
|
  E. Iliaki, V. Poulaki, N. Mitsiades, C. S. Mitsiades, J. W. Miller, and E. S. Gragoudas Role of {alpha}4 Integrin (CD49d) in the Pathogenesis of Diabetic Retinopathy Invest. Ophthalmol. Vis. Sci., October 1, 2009; 50(10): 4898 - 4904. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Meiron, Y. Zohar, R. Anunu, G. Wildbaum, and N. Karin CXCL12 (SDF-1{alpha}) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells J. Exp. Med., October 27, 2008; 205(11): 2643 - 2655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Kerfoot, G. Andonegui, C. S. Bonder, and L. Liu Exogenous stromal cell-derived factor-1 induces modest leukocyte recruitment in vivo Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2524 - H2534. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Miles, E. Liaskou, B. Eksteen, P. F. Lalor, and D. H. Adams CCL25 and CCL28 promote {alpha}4{beta}7-integrin-dependent adhesion of lymphocytes to MAdCAM-1 under shear flow Am J Physiol Gastrointest Liver Physiol, May 1, 2008; 294(5): G1257 - G1267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bastianutto, A. Mian, J. Symes, J. Mocanu, N. Alajez, G. Sleep, W. Shi, A. Keating, M. Crump, M. Gospodarowicz, et al. Local Radiotherapy Induces Homing of Hematopoietic Stem Cells to the Irradiated Bone Marrow Cancer Res., November 1, 2007; 67(21): 10112 - 10116. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Garcia-Bernal, E. Sotillo-Mallo, C. Nombela-Arrieta, R. Samaniego, Y. Fukui, J. V. Stein, and J. Teixido DOCK2 is Required for Chemokine-Promoted Human T Lymphocyte Adhesion Under Shear Stress Mediated by the Integrin {alpha}4beta1 J. Immunol., October 15, 2006; 177(8): 5215 - 5225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Gallego, M. A. de la Fuente, I. M. Anton, S. Snapper, R. Fuhlbrigge, and R. S. Geha WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1{alpha} Int. Immunol., February 1, 2006; 18(2): 221 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Vianello, P. Kraft, Y. T. Mok, W. K. Hart, N. White, and M. C. Poznansky A CXCR4-Dependent Chemorepellent Signal Contributes to the Emigration of Mature Single-Positive CD4 Cells from the Fetal Thymus J. Immunol., October 15, 2005; 175(8): 5115 - 5125. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Smaniotto, V. de Mello-Coelho, D. M. S. Villa-Verde, J.-M. Pleau, M.-C. Postel-Vinay, M. Dardenne, and W. Savino Growth Hormone Modulates Thymocyte Development in Vivo through a Combined Action of Laminin and CXC Chemokine Ligand 12 Endocrinology, July 1, 2005; 146(7): 3005 - 3017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Garcia-Bernal, N. Wright, E. Sotillo-Mallo, C. Nombela-Arrieta, J. V. Stein, X. R. Bustelo, and J. Teixido Vav1 and Rac Control Chemokine-promoted T Lymphocyte Adhesion Mediated by the Integrin {alpha}4{beta}1 Mol. Biol. Cell, July 1, 2005; 16(7): 3223 - 3235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Sela, R. Hershkoviz, L. Cahalon, O. Lider, and E. Mozes Down-Regulation of Stromal Cell-Derived Factor-1{alpha}-Induced T Cell Chemotaxis by a Peptide Based on the Complementarity-Determining Region 1 of an Anti-DNA Autoantibody via Up-Regulation of TGF-{beta} Secretion J. Immunol., January 1, 2005; 174(1): 302 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Katayama, A. Hidalgo, A. Peired, and P. S. Frenette Integrin {alpha}4{beta}7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation Blood, October 1, 2004; 104(7): 2020 - 2026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Heidemann, H. Ogawa, P. Rafiee, N. Lugering, C. Maaser, W. Domschke, D. G. Binion, and M. B. Dwinell Mucosal angiogenesis regulation by CXCR4 and its ligand CXCL12 expressed by human intestinal microvascular endothelial cells Am J Physiol Gastrointest Liver Physiol, June 1, 2004; 286(6): G1059 - G1068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Bartolome, B. G. Galvez, N. Longo, F. Baleux, G. N. P. van Muijen, P. Sanchez-Mateos, A. G. Arroyo, and J. Teixido Stromal Cell-Derived Factor-1{alpha} Promotes Melanoma Cell Invasion across Basement Membranes Involving Stimulation of Membrane-Type 1 Matrix Metalloproteinase and Rho GTPase Activities Cancer Res., April 1, 2004; 64(7): 2534 - 2543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lindholm, A. Naylor, E.-L. Johansson, and M. Quiding-Jarbrink Mucosal Vaccination Increases Endothelial Expression of Mucosal Addressin Cell Adhesion Molecule 1 in the Human Gastrointestinal Tract Infect. Immun., February 1, 2004; 72(2): 1004 - 1009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wright, T. L. de Lera, C. Garcia-Moruja, R. Lillo, F. Garcia-Sanchez, A. Caruz, and J. Teixido Transforming growth factor-{beta}1 down-regulates expression of chemokine stromal cell-derived factor-1: functional consequences in cell migration and adhesion Blood, September 15, 2003; 102(6): 1978 - 1984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Bartolome, F. Sanz-Rodriguez, M. M. Robledo, A. Hidalgo, and J. Teixido Rapid Up-Regulation of alpha 4 Integrin-mediated Leukocyte Adhesion by Transforming Growth Factor-beta 1 Mol. Biol. Cell, January 1, 2003; 14(1): 54 - 66. [Abstract] [Full Text]
|
|
|
|
|
|
E. Wilson, J. F. Hedges, E. C. Butcher, M. Briskin, and M. A. Jutila Bovine {gamma}{delta} T Cell Subsets Express Distinct Patterns of Chemokine Responsiveness and Adhesion Molecules: A Mechanism for Tissue-Specific {gamma}{delta} T Cell Subset Accumulation J. Immunol., November 1, 2002; 169(9): 4970 - 4975. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
