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and Lymphotoxin- Receptor Expression in Mouse Embryos1
* Department of Exploratory Biology, Biogen, Cambridge, MA 02142; and
Department of Dermatology, University of Geneva, Geneva, Switzerland
The heteromeric lymphotoxin 
ligand (LT) binds to the
LT receptor (LTR) and provides an essential trigger for lymph
node (LN) development. LTR signaling is also critical for the
emergence of pathological ectopic lymph node-like structures and the
maintenance of an organized splenic white pulp. To better understand
the role of LT in development, the expression patterns of LT and
LTR mRNA were examined by in situ hybridization in the developing
mouse embryo. Images of LT ligand expression in developing
peripheral LN in the E18.5 embryo revealed a relatively early phase
structure and allowed for comparative staging with LN development in
rat and humans. The LTR is expressed from E16.5 onward in
respiratory, salivary, bronchial, and gastric epithelium, which may be
consistent with early communication events between lymphoid elements
and epithelial specialization over emerging mucosal LN. Direct
comparison of mouse fetal and adult tissues by FACS analysis confirmed
the elevated expression of LTBR in some embryonic epithelial layers.
Therefore, surface LTBR expression may be elevated during fetal
development in some epithelial layers.
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