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* Institut National de la Santé et de la Recherche Médicale, Unité 345, and
Laboratoire d’Expérimentation Animale et de Transgénèse, Faculté de Médecine Necker-Enfants Malades, Université René Descartes, Paris, France
To examine directly whether a limited number of naive T cells
transferred to lymphopenic hosts can truly fill the peripheral naive T
cell pool, we compared the expansion and phenotype of naive T cells
transferred to three different hosts, namely recombination-activating
gene-deficient mice, CD3
-deficient mice, and irradiated normal mice.
In all three recipients, the absolute number of recovered cells was
much smaller than in normal mice. In addition, transferred naive T
cells acquired a memory-like phenotype that remained stable with time.
Finally, injected cells were rapidly replaced by host thymic migrants
in irradiated normal mice. Only continuous output of naive T cells by
the thymus can generate a full compartment of truly naive T cells.
Thus, conversion of naive T cells to a memory-like phenotype in
lymphopenic hosts is not related to a homeostatic mechanism that fills
the peripheral naive T cell pool.
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