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A Role for CD147 in Thymic Development

Toufic Renno^1,2,*, Anne Wilson^1,, Caroline Dunkel^*, Isabelle Coste^2,*, Karine Maisnier-Patin^*, Amélie Benoit de Coignac^*, Jean-Pierre Aubry^*, Rosemary K. Lees, Jean-Yves Bonnefoy^*, H. Robson MacDonald and Jean-François Gauchat^3,*

^* Centre d’Immunologie Pierre Fabre, Saint-Julien en Genevois, France; and Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland

We have previously identified a mAb that binds to a molecule expressed preferentially on the surface of cycling thymocytes. In this study the molecule recognized by this mAb has been identified in the mouse as CD147 (basigin) by expression cloning. We show that CD147 expression correlates with cycling of immature thymocytes even in the absence of TCR selection and that ligation of this molecule on immature fetal thymocytes inhibits their further development into mature T cells.

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