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/CC Chemokine Ligand-20 After Cellular Activation Without Changes in CCR6 Expression or Ligand Binding
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
CCR6 is the only known receptor for the chemokine
macrophage-inflammatory protein (MIP)-3
/CC chemokine ligand (CCL)20.
We have shown previously that CCR6 is expressed on peripheral blood B
cells, but CCR6 activity on these cells is low in in vitro assays. We
report that MIP-3/CCL20-induced calcium flux and chemotaxis can be
enhanced significantly on peripheral blood and tonsillar B cells after
activation by cross-linking surface Ag receptors. Of particular
interest is the fact that the enhanced activity on B cells was not
associated with an increase in CCR6 expression as assessed by levels of
receptor mRNA, surface staining, or MIP-3/CCL20 binding sites, or by
a change in the affinity of the receptor for ligand. These data
convincingly demonstrate that responses to a chemokine can be regulated
solely by changes in the downstream pathways for signal transduction
resulting from Ag receptor activation, and establish CCR6 as an
efficacious receptor on human B cells.
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