The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Derre, L.
Right arrow Articles by Gervois, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Derre, L.
Right arrow Articles by Gervois, N.
The Journal of Immunology, 2002, 168: 4864-4870.
Copyright © 2002 by The American Association of Immunologists

Expression of CD94/NKG2-A on Human T Lymphocytes Is Induced by IL-12: Implications for Adoptive Immunotherapy1

Laurent Derre*, Murielle Corvaisier*, Marie-Christine Pandolfino{dagger}, Elisabeth Diez*, Francine Jotereau* and Nadine Gervois2,*

* Institut National de la Santé et de la Recherche Médicale Unité 463, Institut de Biologie, and {dagger} Unité de Thérapies Cellulaire et Génique, Centre Hospitalier Régional Universitaire, Nantes, France

NK cell receptors (NKRs) are expressed on a subset of human T cells, predominantly CD8+, within which they can modulate TCR-mediated functions. In an attempt to identify the mechanisms leading to NKR expression, we analyzed the capacity of IL-12 to modulate the expression by T cells of the components of the CD94/NKG2-A inhibitory receptor, a member of the C-type lectin-like family of NKR. We show that IL-12 induces the expression of NKG2-A and/or CD94 by CD8+ T cells in culture, and that this induction was mediated neither by IFN-{gamma} nor by IL-15. We also show, using the redirected killing assay, that IL-12-induced expression of both CD94 and NKG2-A led to the acquisition by T cells of a functional inhibitory receptor. Expression of the CD94/NKG2-A inhibitory receptor was also induced by IL-12 during T cell Ag stimulation so that in the presence of this cytokine a high proportion of melanoma-reactive CTL induced from PBL by melanoma peptide stimulation expressed this receptor. This study emphasizes the implication of IL-12 in the modulation of immune responses through NKR induction.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
A. Saez-Borderias, N. Romo, G. Magri, M. Guma, A. Angulo, and M. Lopez-Botet
IL-12-Dependent Inducible Expression of the CD94/NKG2A Inhibitory Receptor Regulates CD94/NKG2C+ NK Cell Function
J. Immunol., January 15, 2009; 182(2): 829 - 836.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
S. Iizuka, T. Kaifu, A. Nakamura, M. Obinata, and T. Takai
Establishment and Functional Characterization of Novel Natural Killer Cell Lines Derived from a Temperature-Sensitive SV40 Large T Antigen Transgenic Mouse
J. Biochem., August 1, 2006; 140(2): 255 - 265.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
H. S. Warren, P. M. Rana, D. T. Rieger, K. A. Hewitt, J. E. Dahlstrom, and A. L. Kent
CD8 T cells expressing killer Ig-like receptors and NKG2A are present in cord blood and express a more naive phenotype than their counterparts in adult blood
J. Leukoc. Biol., June 1, 2006; 79(6): 1252 - 1259.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
B.-C. Sheu, S.-H. Chiou, H.-H. Lin, S.-N. Chow, S.-C. Huang, H.-N. Ho, and S.-M. Hsu
Up-regulation of Inhibitory Natural Killer Receptors CD94/NKG2A with Suppressed Intracellular Perforin Expression of Tumor-Infiltrating CD8+ T Lymphocytes in Human Cervical Carcinoma
Cancer Res., April 1, 2005; 65(7): 2921 - 2929.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Draghi, N. Yawata, M. Gleimer, M. Yawata, N. M. Valiante, and P. Parham
Single-cell analysis of the human NK cell response to missing self and its inhibition by HLA class I
Blood, March 1, 2005; 105(5): 2028 - 2035.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. I. Marusina, D.-K. Kim, L. D. Lieto, F. Borrego, and J. E. Coligan
GATA-3 Is an Important Transcription Factor for Regulating Human NKG2A Gene Expression
J. Immunol., February 15, 2005; 174(4): 2152 - 2159.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Tanaka, T. Toubai, Y. Tsutsumi, Y. Miura, N. Kato, S. Umehara, K. Kahata, A. Mori, N. Toyoshima, S. Ota, et al.
Cytolytic activity and regulatory functions of inhibitory NK cell receptor-expressing T cells expanded from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells
Blood, August 1, 2004; 104(3): 768 - 774.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
G. Saruhan-Direskeneli, F. A. Uyar, A. Cefle, S. C. Onder, E. Eksioglu-Demiralp, S. Kamali, M. Inanc, L. Ocal, and A. Gul
Expression of KIR and C-type lectin receptors in Behcet's disease
Rheumatology, April 1, 2004; 43(4): 423 - 427.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. T. Wilhelm, J.-R. Landry, F. Takei, and D. L. Mager
Transcriptional Control of Murine CD94 Gene: Differential Usage of Dual Promoters by Lymphoid Cell Types
J. Immunol., October 15, 2003; 171(8): 4219 - 4226.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Gunturi, R. E. Berg, and J. Forman
Preferential Survival of CD8 T and NK Cells Expressing High Levels of CD94
J. Immunol., February 15, 2003; 170(4): 1737 - 1745.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.