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Cutting Edge |
Departments of
* Immunology and
Pediatrics and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905; and
Human Genome Sciences, Rockville, MD 20850
Interactions of LIGHT and its receptors, herpesvirus entry
mediator on T cells and lymphotoxin 
receptor on stromal cells, are
implicated in the regulation of lymphoid organogenesis, costimulation
of T cells, and activation of dendritic cells. In this work we report
that LIGHT-deficient mice had normal lymphoid organs with T cells and
APCs that normally responded to Ag stimulation and normally stimulated
T cells. Although the number of V8+ T cells in naive
LIGHT+/+ and LIGHT-/- mice was identical,
V8+CD8+ T cell proliferation in response to
staphylococcal enterotoxin B was significantly lower in
LIGHT-/- mice. Consistently, induction and cytokine
secretion of CD8+ CTL to MHC class I-restricted peptide was
also reduced in LIGHT-/- mice. However, the proliferative
response of V8+CD4+ T cells to
staphylococcal enterotoxin B was comparable in LIGHT-/-
and LIGHT+/+ mice. Our results suggest that LIGHT is
required for activation of normal CD8+ T cells but not
CD4+ T cells.
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