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Cutting Edge |
* Division of Immunology, University of Connecticut Health Center, Farmington, CT 06030;
Committee on Immunology, University of Chicago, Chicago, IL 60637; and
Department of Medicine, Division of Immunology, Harvard Medical School, Boston, MA 02215
IL-15 and IL-15R
are required for generation of
memory-phenotype CD8 T cells in unimmunized mice. However, the role of
IL-15 in primary expansion and generation of Ag-specific memory CD8 T
cells in vivo has not been investigated. We characterized the CD8 T
cell response against vesicular stomatitis virus (VSV) in
IL-15-/- and IL-15R-/- mice.
Surprisingly, IL-15 was required for primary expansion of VSV-specific
CD8 T cells. The generation of VSV-specific memory CD8 T cells was also
impaired without IL-15 signaling, and this defect correlated with a
decrease in memory CD8 T cell turnover. Despite minimal proliferation
without IL-15, a subset of memory cells survived long-term. IL-15R
expression was low on naive CD8 T cells, up-regulated on Ag-specific
effector cells, and sustained on memory cells. Thus, IL-15 was
important for the generation and the subsequent maintenance of
antiviral memory CD8 T cells.
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R. M. Teague, R. M. Tempero, S. Thomas, K. Murali-Krishna, and B. H. Nelson Proliferation and Differentiation of CD8+ T Cells in the Absence of IL-2/15 Receptor {beta}-Chain Expression or STAT5 Activation J. Immunol., September 1, 2004; 173(5): 3131 - 3139. [Abstract] [Full Text] [PDF]
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J. J. Obar, S. G. Crist, E. K. Leung, and E. J. Usherwood IL-15-Independent Proliferative Renewal of Memory CD8+ T Cells in Latent Gammaherpesvirus Infection J. Immunol., August 15, 2004; 173(4): 2705 - 2714. [Abstract] [Full Text] [PDF]
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G. Ratzinger, J. Baggers, M. A. de Cos, J. Yuan, T. Dao, J. L. Reagan, C. Munz, G. Heller, and J. W. Young Mature Human Langerhans Cells Derived from CD34+ Hematopoietic Progenitors Stimulate Greater Cytolytic T Lymphocyte Activity in the Absence of Bioactive IL-12p70, by Either Single Peptide Presentation or Cross-Priming, Than Do Dermal-Interstitial or Monocyte-Derived Dendritic Cells J. Immunol., August 15, 2004; 173(4): 2780 - 2791. [Abstract] [Full Text] [PDF]
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G. C. Hildebrandt, L. A. Corrion, K. M. Olkiewicz, B. Lu, K. Lowler, U. A. Duffner, B. B. Moore, W. A. Kuziel, C. Liu, and K. R. Cooke Blockade of CXCR3 Receptor:Ligand Interactions Reduces Leukocyte Recruitment to the Lung and the Severity of Experimental Idiopathic Pneumonia Syndrome J. Immunol., August 1, 2004; 173(3): 2050 - 2059. [Abstract] [Full Text] [PDF]
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D. C. Lenz, S. K. Kurz, E. Lemmens, S. P. Schoenberger, J. Sprent, M. B. A. Oldstone, and D. Homann IL-7 regulates basal homeostatic proliferation of antiviral CD4+T cell memory PNAS, June 22, 2004; 101(25): 9357 - 9362. [Abstract] [Full Text] [PDF]
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E. J. Wherry and R. Ahmed Memory CD8 T-Cell Differentiation during Viral Infection J. Virol., June 1, 2004; 78(11): 5535 - 5545. [Full Text] [PDF]
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J. J. Lum, D. J. Schnepple, Z. Nie, J. Sanchez-Dardon, G. L. Mbisa, J. Mihowich, N. Hawley, S. Narayan, J. E. Kim, D. H. Lynch, et al. Differential Effects of Interleukin-7 and Interleukin-15 on NK Cell Anti-Human Immunodeficiency Virus Activity J. Virol., June 1, 2004; 78(11): 6033 - 6042. [Abstract] [Full Text] [PDF]
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Z. Wu, M. Roberts, M. Porter, F. Walker, E. J. Wherry, J. Kelly, M. Gadina, E. M. Silva, G. A. DosReis, M. F. Lopes, et al. Viral FLIP Impairs Survival of Activated T Cells and Generation of CD8+ T Cell Memory J. Immunol., May 15, 2004; 172(10): 6313 - 6323. [Abstract] [Full Text] [PDF]
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K. S. Schluns, E. C. Nowak, A. Cabrera-Hernandez, L. Puddington, L. Lefrancois, and H. L. Aguila Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor {alpha} expression PNAS, April 13, 2004; 101(15): 5616 - 5621. [Abstract] [Full Text] [PDF]
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J. Castelli, E. K. Thomas, M. Gilliet, Y.-J. Liu, and J. A. Levy Mature dendritic cells can enhance CD8+ cell noncytotoxic anti-HIV responses: the role of IL-15 Blood, April 1, 2004; 103(7): 2699 - 2704. [Abstract] [Full Text] [PDF]
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J. Chang, J.-H. Cho, S.-W. Lee, S.-Y. Choi, S.-J. Ha, and Y.-C. Sung IL-12 Priming during In Vitro Antigenic Stimulation Changes Properties of CD8 T Cells and Increases Generation of Effector and Memory Cells J. Immunol., March 1, 2004; 172(5): 2818 - 2826. [Abstract] [Full Text] [PDF]
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S.-K. Kim and R. M. Welsh Comprehensive Early and Lasting Loss of Memory CD8 T Cells and Functional Memory during Acute and Persistent Viral Infections J. Immunol., March 1, 2004; 172(5): 3139 - 3150. [Abstract] [Full Text] [PDF]
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K. S. Schluns, K. D. Klonowski, and L. Lefrancois Transregulation of memory CD8 T-cell proliferation by IL-15R{alpha}+ bone marrow-derived cells Blood, February 1, 2004; 103(3): 988 - 994. [Abstract] [Full Text] [PDF]
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J. J. Obar, S. G. Crist, D. C. Gondek, and E. J. Usherwood Different Functional Capacities of Latent and Lytic Antigen-Specific CD8 T Cells in Murine Gammaherpesvirus Infection J. Immunol., January 15, 2004; 172(2): 1213 - 1219. [Abstract] [Full Text] [PDF]
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R. Vankayalapati, P. Klucar, B. Wizel, S. E. Weis, B. Samten, H. Safi, H. Shams, and P. F. Barnes NK Cells Regulate CD8+ T Cell Effector Function in Response to an Intracellular Pathogen J. Immunol., January 1, 2004; 172(1): 130 - 137. [Abstract] [Full Text] [PDF]
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W. N. D'Souza and L. Lefrancois IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion J. Immunol., December 1, 2003; 171(11): 5727 - 5735. [Abstract] [Full Text] [PDF]
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M. A. Burchill, C. A. Goetz, M. Prlic, J. J. O'Neil, I. R. Harmon, S. J. Bensinger, L. A. Turka, P. Brennan, S. C. Jameson, and M. A. Farrar Distinct Effects of STAT5 Activation on CD4+ and CD8+ T Cell Homeostasis: Development of CD4+CD25+ Regulatory T Cells versus CD8+ Memory T Cells J. Immunol., December 1, 2003; 171(11): 5853 - 5864. [Abstract] [Full Text] [PDF]
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M. Jinushi, T. Takehara, T. Tatsumi, T. Kanto, V. Groh, T. Spies, T. Suzuki, T. Miyagi, and N. Hayashi Autocrine/Paracrine IL-15 That Is Required for Type I IFN-Mediated Dendritic Cell Expression of MHC Class I-Related Chain A and B Is Impaired in Hepatitis C Virus Infection J. Immunol., November 15, 2003; 171(10): 5423 - 5429. [Abstract] [Full Text] [PDF]
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K. H. Ely, A. D. Roberts, and D. L. Woodland Cutting Edge: Effector Memory CD8+ T Cells in the Lung Airways Retain the Potential to Mediate Recall Responses J. Immunol., October 1, 2003; 171(7): 3338 - 3342. [Abstract] [Full Text] [PDF]
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N. L. Alves, B. Hooibrink, F. A. Arosa, and R. A. W. van Lier IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro Blood, October 1, 2003; 102(7): 2541 - 2546. [Abstract] [Full Text] [PDF]
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L. Lefrancois, A. Marzo, and K. Williams Sustained Response Initiation Is Required for T Cell Clonal Expansion But Not for Effector or Memory Development In Vivo J. Immunol., September 15, 2003; 171(6): 2832 - 2839. [Abstract] [Full Text] [PDF]
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 F. G. Lakkis and M. H. Sayegh Memory T Cells: A Hurdle to Immunologic Tolerance J. Am. Soc. Nephrol., September 1, 2003; 14(9): 2402 - 2410. [Full Text] [PDF]
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