The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     
 


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Arnett, H. A.
Right arrow Articles by Ting, J. P.-Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arnett, H. A.
Right arrow Articles by Ting, J. P.-Y.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*L-TYROSINE
*NITRIC OXIDE
The Journal of Immunology, 2002, 168: 427-433.
Copyright © 2002 by The American Association of Immunologists

The Protective Role of Nitric Oxide in a Neurotoxicant- Induced Demyelinating Model1

Heather A. Arnett2,*,{dagger}, Ron P. Hellendall2,*, Glenn K. Matsushima{dagger},{ddagger}, Kinuko Suzuki{dagger}, Victor E. Laubach§, Paula Sherman and Jenny P.-Y. Ting3,*,{dagger},{ddagger}

* Lineberger Comprehensive Cancer Center, {dagger} Neurobiology Curriculum, and {ddagger} Department of Microbiology/Immunology, University of North Carolina, Chapel Hill, NC 27599; § Department of Surgery, University of Virginia Health Sciences Center, Charlottesville, VA 22908; and Department of Human Genetics, Glaxo Wellcome Research Institute, Research Triangle Park, NC 27709

Demyelination is often associated with acute inflammatory events involving the recruitment-activation of microglia/macrophage, astrocytes, and leukocytes. The ultimate role of inflammatory products in demyelinating disease and in the survival of oligodendrocytes, the myelin forming cells, is unresolved. The current study examines the role of inducible NO synthase (iNOS)-derived NO in a neurotoxicant-induced model of demyelination. NO levels were greatly elevated in the midline corpus callosum during demyelination in genetically intact C57BL/6 mice, and this NO was due solely to the induction of iNOS, as the correlates of NO were not found in mice lacking iNOS. C57BL/6 mice lacking iNOS exhibited more demyelination, but did not display an increased overall cellularity in the corpus callosum, attributable to an unimpeded microglia/macrophage presence. An enhanced course of pathology was noted in mice lacking iNOS. This was associated with a greater depletion of mature oligodendrocytes, most likely due to apoptosis of oligodendrocytes. Microglia and astrocytes did not undergo apoptosis during treatment. Our results suggest a moderately protective role for NO during acute inflammation-association demyelination.




This article has been cited by other articles:


Home page
J. Neurosci.Home page
M. D. Binder, H. S. Cate, A. L. Prieto, D. Kemper, H. Butzkueven, M. M. Gresle, T. Cipriani, V. G. Jokubaitis, P. Carmeliet, and T. J. Kilpatrick
Gas6 Deficiency Increases Oligodendrocyte Loss and Microglial Activation in Response to Cuprizone-Induced Demyelination
J. Neurosci., May 14, 2008; 28(20): 5195 - 5206.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
S. R. Plant, H. A. Iocca, Y. Wang, J. C. Thrash, B. P. O'Connor, H. A. Arnett, Y.-X. Fu, M. J. Carson, and J. P.-Y. Ting
Lymphotoxin {beta} Receptor (Lt{beta}R): Dual Roles in Demyelination and Remyelination and Successful Therapeutic Intervention Using Lt{beta}R-Ig Protein
J. Neurosci., July 11, 2007; 27(28): 7429 - 7437.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
D. Linares, M. Taconis, P. Mana, M. Correcha, S. Fordham, M. Staykova, and D. O. Willenborg
Neuronal Nitric Oxide Synthase Plays a Key Role in CNS Demyelination
J. Neurosci., December 6, 2006; 26(49): 12672 - 12681.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
P. Mana, D. Linares, S. Fordham, M. Staykova, and D. Willenborg
Deleterious Role of IFN{gamma} in a Toxic Model of Central Nervous System Demyelination
Am. J. Pathol., May 1, 2006; 168(5): 1464 - 1473.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Y. Zhang, H. Wang, J. Li, L. Dong, P. Xu, W. Chen, R. L. Neve, J. J. Volpe, and P. A. Rosenberg
Intracellular Zinc Release and ERK Phosphorylation Are Required Upstream of 12-Lipoxygenase Activation in Peroxynitrite Toxicity to Mature Rat Oligodendrocytes
J. Biol. Chem., April 7, 2006; 281(14): 9460 - 9470.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
J. L. Mason, A. Toews, J. D. Hostettler, P. Morell, K. Suzuki, J. E. Goldman, and G. K. Matsushima
Oligodendrocytes and Progenitors Become Progressively Depleted within Chronically Demyelinated Lesions
Am. J. Pathol., May 1, 2004; 164(5): 1673 - 1682.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
S. Hortelano, P. G. Traves, M. Zeini, A. M. Alvarez, and L. Bosca
Sustained Nitric Oxide Delivery Delays Nitric Oxide-Dependent Apoptosis in Macrophages: Contribution to the Physiological Function of Activated Macrophages
J. Immunol., December 1, 2003; 171(11): 6059 - 6064.
[Abstract] [Full Text] [PDF]


Home page
J. Neurosci.Home page
H. A. Arnett, Y. Wang, G. K. Matsushima, K. Suzuki, and J. P.-Y. Ting
Functional Genomic Analysis of Remyelination Reveals Importance of Inflammation in Oligodendrocyte Regeneration
J. Neurosci., October 29, 2003; 23(30): 9824 - 9832.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2002 by The American Association of Immunologists, Inc. All rights reserved.