| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Secretion by Type 2 Predendritic Cells Up-Regulates MHC Class I in the HIV-1-Infected Thymus1
,
*
Gladstone Institute of Virology and Immunology,
Biomedical Sciences Graduate Program, and Departments of
Medicine and
Microbiology and Immunology, University of California, San Francisco, CA 94143
The ability of HIV-1 to evade the host immune response leads to the
establishment of chronic infection. HIV-1 has been reported to
up-regulate MHC I molecules on the surface of thymocytes from
HIV-1-infected thymus. We demonstrate in this study that HIV-1
up-regulates MHC I on both HIV-1-infected and uninfected thymocytes in
a manner that is independent of Nef, proportional to viral replication,
and entirely mediated by IFN-
. IL-3R+ type 2
predendritic cells (preDC2) resident in the thymic medulla secrete
IFN-, which acts on IFN-
R-expressing immature thymocytes to
induce MHC I expression. Furthermore, thymic preDC2 are permissive for
HIV-1 infection and positive for intracellular p24. These data
demonstrate the ability of IFN- secreted by preDC2 to induce MHC I
up-regulation in the HIV-1-infected human thymus.
This article has been cited by other articles:
|
|
 |
|
  T. Demoulins, A. Abdallah, N. Kettaf, M.-L. Baron, C. Gerarduzzi, D. Gauchat, S. Gratton, and R.-P. Sekaly Reversible Blockade of Thymic Output: An Inherent Part of TLR Ligand-Mediated Immune Response J. Immunol., November 15, 2008; 181(10): 6757 - 6769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Schweneker, D. Favre, J. N. Martin, S. G. Deeks, and J. M. McCune HIV-Induced Changes in T Cell Signaling Pathways J. Immunol., May 15, 2008; 180(10): 6490 - 6500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Schmidlin, W. Dontje, F. Groot, S. J. Ligthart, A. D. Colantonio, M. E. Oud, E. J. Schilder-Tol, M. Spaargaren, H. Spits, C. H. Uittenbogaart, et al. Stimulated plasmacytoid dendritic cells impair human T-cell development Blood, December 1, 2006; 108(12): 3792 - 3800. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hosmalin and P. Lebon Type I interferon production in HIV-infected patients J. Leukoc. Biol., November 1, 2006; 80(5): 984 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Donaghy, J. Wilkinson, and A. L. Cunningham HIV interactions with dendritic cells: has our focus been too narrow? J. Leukoc. Biol., November 1, 2006; 80(5): 1001 - 1012. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Del Corno, M. C. Gauzzi, G. Penna, F. Belardelli, L. Adorini, and S. Gessani Human Immunodeficiency Virus Type 1 gp120 and Other Activation Stimuli Are Highly Effective in Triggering Alpha Interferon and CC Chemokine Production in Circulating Plasmacytoid but Not Myeloid Dendritic Cells J. Virol., October 1, 2005; 79(19): 12597 - 12601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Cole, W. Yan, Z. Galic, J. Arevalo, and J. A. Zack Expression-based monitoring of transcription factor activity: the TELiS database Bioinformatics, March 15, 2005; 21(6): 803 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Choudhary, N. R. Choudhary, K. C. Kimbrell, J. Colasanti, A. Ziogas, D. Kwa, H. Schuitemaker, and D. Camerini R5 Human Immunodeficiency Virus Type 1 Infection of Fetal Thymic Organ Culture Induces Cytokine and CCR5 Expression J. Virol., January 1, 2005; 79(1): 458 - 471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Gurney, A. D. Colantonio, B. Blom, H. Spits, and C. H. Uittenbogaart Endogenous IFN-{alpha} Production by Plasmacytoid Dendritic Cells Exerts an Antiviral Effect on Thymic HIV-1 Infection J. Immunol., December 15, 2004; 173(12): 7269 - 7276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ueno, H. Tomiyama, M. Fujiwara, S. Oka, and M. Takiguchi Functionally Impaired HIV-Specific CD8 T Cells Show High Affinity TCR-Ligand Interactions J. Immunol., November 1, 2004; 173(9): 5451 - 5457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Brilot, V. Geenen, D. Hober, and C. A. Stoddart Coxsackievirus B4 Infection of Human Fetal Thymus Cells J. Virol., September 15, 2004; 78(18): 9854 - 9861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Turville, J. Wilkinson, P. Cameron, J. Dable, and A. L. Cunningham The role of dendritic cell C-type lectin receptors in HIV pathogenesis J. Leukoc. Biol., November 1, 2003; 74(5): 710 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Keir, M. G. Rosenberg, J. K. Sandberg, K. A. Jordan, A. Wiznia, D. F. Nixon, C. A. Stoddart, and J. M. McCune Generation of CD3+CD8low Thymocytes in the HIV Type 1-Infected Thymus J. Immunol., September 1, 2002; 169(5): 2788 - 2796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Abel, M. J. Alegria-Hartman, K. Rothaeusler, M. Marthas, and C. J. Miller The Relationship between Simian Immunodeficiency Virus RNA Levels and the mRNA Levels of Alpha/Beta Interferons (IFN-{alpha}/{beta}) and IFN-{alpha}/{beta}-Inducible Mx in Lymphoid Tissues of Rhesus Macaques during Acute and Chronic Infection J. Virol., July 17, 2002; 76(16): 8433 - 8445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pedroza-Martins, W. J. Boscardin, D. J. Anisman-Posner, D. Schols, Y. J. Bryson, and C. H. Uittenbogaart Impact of Cytokines on Replication in the Thymus of Primary Human Immunodeficiency Virus Type 1 Isolates from Infants J. Virol., June 14, 2002; 76(14): 6929 - 6943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-O. Vidalain, D. Laine, Y. Zaffran, O. Azocar, C. Servet-Delprat, T. F. Wild, C. Rabourdin-Combe, and H. Valentin Interferons Mediate Terminal Differentiation of Human Cortical Thymic Epithelial Cells J. Virol., June 5, 2002; 76(13): 6415 - 6424. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
