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*
Departments of Biomedical Sciences and
Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada;
Institute of Cellular and Molecular Biology, University of Texas, Austin, TX 78712;
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599; and
¶ Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263
Uterine NK (uNK) cells are abundant in human and murine uteri
during decidualization. It is unclear whether precursors of uNK
(pre-uNK) cells self-renew or are recruited from other sites. To assess
self-renewal of pre-uNK cells, uterine segments from NK cell-competent
mice were grafted orthotopically into NK/uNK cell-deficient or
wild-type mice. Only in wild-type recipients did decidualized grafts
contain uNK cells, indicating that pre-uNK cells do not self-renew in
uterus. To identify pre-uNK cell sources, thymus, bone marrow, lymph
node, or spleen cells were grafted from virgin or pregnant NK
cell-competent donors into mated NK/uNK cell-deficient recipients.
Cells from secondary lymphoid tissues of pregnant donors gave high
level uNK cell reconstitution, which was independent of chemokine
receptors CCR2 or CCR5. Pregnancy-induced changes to
lymphocyte-endothelial cell interactions were documented using adhesion
of human lymphocytes to frozen mouse tissue sections under shear. A
dynamic increase was observed in L-selectin- and 
4
integrin-dependent adhesion of CD56bright NK cells to
decidualizing uterus and in human PBL adhesion to lymph node
endothelium. These data support a model that attributes the dramatic
increases in human and murine uNK cells during decidualization to
precursor cell recruitment.
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