| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cutting Edge |
,
Departments of
*
Neurology and
Microbiology and Immunology and
The Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642; and
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
IL-10 has potent immunosuppressive properties, and
IL-10-producing CD4+ Tr1 cells have been characterized as
regulators of Th1-mediated immunity. In this study, using a s.c. model
of glioma cell growth in mice, we demonstrate that CD4+,
but not CD8+, T cells play a critical role in tumor
rejection following vaccination with irradiated glioma cells.
Surprisingly, glioma-specific CD4+ T cells produce IL-10
but neither IL-4 nor IFN-
, and glioma rejection is compromised in
IL-10-/- hosts. Hence, our findings demonstrate that
IL-10-producing CD4+ T cells can manifest antitumor
functions and suggest that IL-10 may have proinflammatory effects in
disease states.
This article has been cited by other articles:
|
|
 |
|
  D. Atanackovic, N. K. Altorki, Y. Cao, E. Ritter, C. A. Ferrara, G. Ritter, E. W. Hoffman, C. Bokemeyer, L. J. Old, and S. Gnjatic Booster vaccination of cancer patients with MAGE-A3 protein reveals long-term immunological memory or tolerance depending on priming PNAS, February 5, 2008; 105(5): 1650 - 1655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Numasaki, M. Tagawa, F. Iwata, T. Suzuki, A. Nakamura, M. Okada, Y. Iwakura, S. Aiba, and M. Yamaya IL-28 Elicits Antitumor Responses against Murine Fibrosarcoma J. Immunol., April 15, 2007; 178(8): 5086 - 5098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wahl, P. Bochtler, R. Schirmbeck, and J. Reimann Type I IFN-Producing CD4 V{alpha}14i NKT Cells Facilitate Priming of IL-10-Producing CD8 T Cells by Hepatocytes J. Immunol., February 15, 2007; 178(4): 2083 - 2093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Ding, L. Lu, B. Wang, Y. Zhou, Y. Jiang, X. Zhou, L. Xin, Z. Jiao, and K.-Y. Chou B7H1-Ig Fusion Protein Activates the CD4+ IFN-{gamma} Receptor+ Type 1 T Regulatory Subset through IFN-{gamma}-Secreting Th1 Cells J. Immunol., September 15, 2006; 177(6): 3606 - 3614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Mocellin, F. M. Marincola, and H. A. Young Interleukin-10 and the immune response against cancer: a counterpoint J. Leukoc. Biol., November 1, 2005; 78(5): 1043 - 1051. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Erdman, J. J. Sohn, V. P. Rao, P. R. Nambiar, Z. Ge, J. G. Fox, and D. B. Schauer CD4+CD25+ Regulatory Lymphocytes Induce Regression of Intestinal Tumors in ApcMin/+ Mice Cancer Res., May 15, 2005; 65(10): 3998 - 4004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Park, M. Terabe, Y. Sakai, J. Munasinghe, G. Forni, J. C. Morris, and J. A. Berzofsky Early Role of CD4+ Th1 Cells and Antibodies in HER-2 Adenovirus Vaccine Protection against Autochthonous Mammary Carcinomas J. Immunol., April 1, 2005; 174(7): 4228 - 4236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Atanackovic, N. K. Altorki, E. Stockert, B. Williamson, A. A. Jungbluth, E. Ritter, D. Santiago, C. A. Ferrara, M. Matsuo, A. Selvakumar, et al. Vaccine-Induced CD4+ T Cell Responses to MAGE-3 Protein in Lung Cancer Patients J. Immunol., March 1, 2004; 172(5): 3289 - 3296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-L. Ma, M. J. Whitters, R. F. Konz, M. Senices, D. A. Young, M. J. Grusby, M. Collins, and K. Dunussi-Joannopoulos IL-21 Activates Both Innate and Adaptive Immunity to Generate Potent Antitumor Responses that Require Perforin but Are Independent of IFN-{gamma} J. Immunol., July 15, 2003; 171(2): 608 - 615. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Yang and E. C. Lattime Tumor-induced Interleukin 10 Suppresses the Ability of Splenic Dendritic Cells to Stimulate CD4 and CD8 T-Cell Responses Cancer Res., May 1, 2003; 63(9): 2150 - 2157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Erdman, T. Poutahidis, M. Tomczak, A. B. Rogers, K. Cormier, B. Plank, B. H. Horwitz, and J. G. Fox CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice Am. J. Pathol., February 1, 2003; 162(2): 691 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Xainli, M. Baisor, W. Kastens, M. Bockarie, J. H. Adams, and C. L. King Age-Dependent Cellular Immune Responses to Plasmodium vivax Duffy Binding Protein in Humans J. Immunol., September 15, 2002; 169(6): 3200 - 3207. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
