| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
2-Microglobulin Gene Transactivation1
*
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands; and
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322
The promoter regions of MHC class I and
2-microglobulin (2m) genes posses a
regulatory module consisting of S, X, and Y boxes, which is shared by
MHC class II and its accessory genes. In this study we show that,
similar to MHC class II, the SXY module in MHC class I and
2m promoters is cooperatively bound by a multiprotein
complex containing regulatory factor X, CREB/activating transcription
factor, and nuclear factor Y. Together with the coactivator
class II transactivator this multiprotein complex drives
transactivation of these genes. In contrast to MHC class II, the
multiprotein complex has an additional function in the constitutive
transactivation of MHC class I and 2m genes. The
requirement for all transcription factors in the complex and correct
spacing of the binding sites within the SXY regulatory module for
complex formation and functioning of this multiprotein complex strongly
suggests that this complex can be regarded as a bona fide enhanceosome.
The general coactivators CREB binding protein, p300, general control
nonderepressible-5, and p300/CREB binding protein-associated
factor exert an ancillary function in MHC class I and 2m
transactivation, but exclusively through the class II transactivator
component of this enhanceosome. Thus, the SXY module is the basis for a
specific enhanceosome important for the constitutive and inducible
transactivation of MHC class I and 2m
genes.
This article has been cited by other articles:
|
|
 |
|
  D. Pons, F. R. de Vries, P. J. van den Elsen, B. T. Heijmans, P. H.A. Quax, and J. W. Jukema Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease Eur. Heart J., February 1, 2009; 30(3): 266 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. F. Kuipers, P. J. Biesta, L. J. Montagne, E. S. van Haastert, P. van der Valk, and P. J. van den Elsen CC chemokine receptor 5 gene promoter activation by the cyclic AMP response element binding transcription factor Blood, September 1, 2008; 112(5): 1610 - 1619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Moon, S. M. Veniamin, J. A. Parks-Dely, and K. E. Magor The MHC of the Duck (Anas platyrhynchos) Contains Five Differentially Expressed Class I Genes J. Immunol., November 15, 2005; 175(10): 6702 - 6712. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Rohrer, F. R. Pinto, K. E. Hulse, H. R. Lohr, L. Zhang, and J. S. Almeida Multidestructive Pathways Triggered in Photoreceptor Cell Death of the RD Mouse as Determined through Gene Expression Profiling J. Biol. Chem., October 1, 2004; 279(40): 41903 - 41910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Magor, B. P. Shum, and P. Parham The {beta}2-Microglobulin Locus of Rainbow Trout (Oncorhynchus mykiss) Contains Three Polymorphic Genes J. Immunol., March 15, 2004; 172(6): 3635 - 3643. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Tzortzakaki, C. Spilianakis, E. Zika, A. Kretsovali, and J. Papamatheakis Steroid Receptor Coactivator 1 Links the Steroid and Interferon {gamma} Response Pathways Mol. Endocrinol., December 1, 2003; 17(12): 2509 - 2518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. P. Gobin, P. Biesta, and P. J. Van den Elsen Regulation of human beta 2-microglobulin transactivation in hematopoietic cells Blood, April 15, 2003; 101(8): 3058 - 3064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Nowling, C. Bernadt, L. Johnson, M. Desler, and A. Rizzino The Co-activator p300 Associates Physically with and Can Mediate the Action of the Distal Enhancer of the FGF-4 Gene J. Biol. Chem., April 11, 2003; 278(16): 13696 - 13705. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Johnson Locus-Specific Constitutive and Cytokine-Induced HLA Class I Gene Expression J. Immunol., February 15, 2003; 170(4): 1894 - 1902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. van der Stoep, E. Quinten, and P. J. van den Elsen Transcriptional Regulation of the MHC Class II Trans-Activator (CIITA) Promoter III: Identification of a Novel Regulatory Region in the 5'-Untranslated Region and an Important Role for cAMP-Responsive Element Binding Protein 1 and Activating Transcription Factor-1 in CIITA-Promoter III Transcriptional Activation in B Lymphocytes J. Immunol., November 1, 2002; 169(9): 5061 - 5071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. P. Gobin, P. Biesta, J. E. M. de Steenwinkel, G. Datema, and P. J. Van den Elsen HLA-G Transactivation by cAMP-response Element-binding Protein (CREB). AN ALTERNATIVE TRANSACTIVATION PATHWAY TO THE CONSERVED MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS I REGULATORY ROUTES J. Biol. Chem., October 11, 2002; 277(42): 39525 - 39531. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
