The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Granger, S. W.
Right arrow Articles by Ware, C. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Granger, S. W.
Right arrow Articles by Ware, C. F.
The Journal of Immunology, 2001, 167: 5122-5128.
Copyright © 2001 by The American Association of Immunologists

Genomic Characterization of LIGHT Reveals Linkage to an Immune Response Locus on Chromosome 19p13.3 and Distinct Isoforms Generated by Alternate Splicing or Proteolysis1 ,2

Steve W. Granger, Kris D. Butrovich, Pantea Houshmand, Wilson R. Edwards and Carl F. Ware3

Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121

LIGHT is a member of the TNF cytokine superfamily that signals through the lymphotoxin (LT){beta} receptor and the herpesvirus entry mediator. LIGHT may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus, which may provide significant selective pressure shaping the evolution of LIGHT. Here, we define the molecular genetics of the human LIGHT locus, revealing its close linkage to the TNF superfamily members CD27 ligand and 4-1BB ligand, and the third complement protein (C3), which positions LIGHT within the MHC paralog on chromosome 19p13.3. An alternately spliced isoform of LIGHT mRNA that encodes a transmembrane-deleted form is detected in activated T cells and gives rise to a nonglycosylated protein that resides in the cytosol. Furthermore, membrane LIGHT is shed from the cell surface of human 293 T cells. These studies reveal new mechanisms involved in regulating the physical forms and cellular compartmentalization of LIGHT that may contribute to the regulation and biological function of this cytokine.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
C. Wang, T. Wen, J.-P. Routy, N. F. Bernard, R. P. Sekaly, and T. H. Watts
4-1BBL Induces TNF Receptor-Associated Factor 1-Dependent Bim Modulation in Human T Cells and Is a Critical Component in the Costimulation-Dependent Rescue of Functionally Impaired HIV-Specific CD8 T Cells
J. Immunol., December 15, 2007; 179(12): 8252 - 8263.
[Abstract] [Full Text] [PDF]

Home page
 Rheumatology (Oxford)Home page
M. Pierer, F. Brentano, J. Rethage, U. Wagner, H. Hantzschel, R. E. Gay, S. Gay, and D. Kyburz
The TNF superfamily member LIGHT contributes to survival and activation of synovial fibroblasts in rheumatoid arthritis
Rheumatology, July 1, 2007; 46(7): 1063 - 1070.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
B. J Sedgmen, W. Dawicki, J. L Gommerman, K. Pfeffer, and T. H Watts
LIGHT is dispensable for CD4+ and CD8+ T cell and antibody responses to influenza A virus in mice
Int. Immunol., May 1, 2006; 18(5): 797 - 806.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R.-I. You, M.-C. Chen, H.-W. Wang, Y.-C. Chou, C.-H. Lin, and S.-L. Hsieh
Inhibition of Lymphotoxin-{beta} Receptor-Mediated Cell Death by Survivin-{Delta}Ex3.
Cancer Res., March 15, 2006; 66(6): 3051 - 3061.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A.-C. Iversen, P. S. Norris, C. F. Ware, and C. A. Benedict
Human NK Cells Inhibit Cytomegalovirus Replication through a Noncytolytic Mechanism Involving Lymphotoxin-Dependent Induction of IFN-{beta}
J. Immunol., December 1, 2005; 175(11): 7568 - 7574.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y.-G. Wang, K. D. Kim, J. Wang, P. Yu, and Y.-X. Fu
Stimulating Lymphotoxin {beta} Receptor on the Dendritic Cells Is Critical for Their Homeostasis and Expansion
J. Immunol., November 15, 2005; 175(10): 6997 - 7002.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. C. Cheung, I. R. Humphreys, K. G. Potter, P. S. Norris, H. M. Shumway, B. R. Tran, G. Patterson, R. Jean-Jacques, M. Yoon, P. G. Spear, et al.
From The Cover: Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway
PNAS, September 13, 2005; 102(37): 13218 - 13223.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Wang, R. A. Anders, Y. Wang, J. R. Turner, C. Abraham, K. Pfeffer, and Y.-X. Fu
The Critical Role of LIGHT in Promoting Intestinal Inflammation and Crohn's Disease
J. Immunol., June 15, 2005; 174(12): 8173 - 8182.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
R. Mortarini, A. Scarito, D. Nonaka, M. Zanon, I. Bersani, E. Montaldi, E. Pennacchioli, R. Patuzzo, M. Santinami, and A. Anichini
Constitutive Expression and Costimulatory Function of LIGHT/TNFSF14 on Human Melanoma Cells and Melanoma-Derived Microvesicles
Cancer Res., April 15, 2005; 65(8): 3428 - 3436.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
O. Cohavy, J. Zhou, C. F. Ware, and S. R. Targan
LIGHT Is Constitutively Expressed on T and NK Cells in the Human Gut and Can Be Induced by CD2-Mediated Signaling
J. Immunol., January 15, 2005; 174(2): 646 - 653.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. DiPerna, J. Stack, A. G. Bowie, A. Boyd, G. Kotwal, Z. Zhang, S. Arvikar, E. Latz, K. A. Fitzgerald, and W. L. Marshall
Poxvirus Protein N1L Targets the I-{kappa}B Kinase Complex, Inhibits Signaling to NF-{kappa}B by the Tumor Necrosis Factor Superfamily of Receptors, and Inhibits NF-{kappa}B and IRF3 Signaling by Toll-like Receptors
J. Biol. Chem., August 27, 2004; 279(35): 36570 - 36578.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
O. Cohavy, J. Zhou, S. W. Granger, C. F. Ware, and S. R. Targan
LIGHT Expression by Mucosal T Cells May Regulate IFN-{gamma} Expression in the Intestine
J. Immunol., July 1, 2004; 173(1): 251 - 258.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. M. Gill and J. S. Hunt
Soluble Receptor (DcR3) and Cellular Inhibitor of Apoptosis-2 (cIAP-2) Protect Human Cytotrophoblast Cells Against LIGHT-Mediated Apoptosis
Am. J. Pathol., July 1, 2004; 165(1): 309 - 317.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. L Gavin, D. Ait-Azzouzene, C. F. Ware, and D. Nemazee
{Delta}BAFF, an Alternate Splice Isoform That Regulates Receptor Binding and Biopresentation of the B Cell Survival Cytokine, BAFF
J. Biol. Chem., October 3, 2003; 278(40): 38220 - 38228.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. M. Gill, J. Ni, and J. S. Hunt
Differential Expression of LIGHT and Its Receptors in Human Placental Villi and Amniochorion Membranes
Am. J. Pathol., December 1, 2002; 161(6): 2011 - 2017.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Castellano, C. Van Lint, V. Peri, E. Veithen, Y. Morel, R. Costello, D. Olive, and Y. Collette
Mechanisms Regulating Expression of the Tumor Necrosis Factor-related light Gene. ROLE OF CALCIUM-SIGNALING PATHWAY IN THE TRANSCRIPTIONAL CONTROL
J. Biol. Chem., November 1, 2002; 277(45): 42841 - 42851.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Scheu, J. Alferink, T. Potzel, W. Barchet, U. Kalinke, and K. Pfeffer
Targeted Disruption of LIGHT Causes Defects in Costimulatory T Cell Activation and Reveals Cooperation with Lymphotoxin {beta} in Mesenteric Lymph Node Genesis
J. Exp. Med., June 17, 2002; 195(12): 1613 - 1624.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
Q. Ye, C. C. Fraser, W. Gao, L. Wang, S. J. Busfield, C. Wang, Y. Qiu, A. J. Coyle, J.-C. Gutierrez-Ramos, and W. W. Hancock
Modulation of LIGHT-HVEM Costimulation Prolongs Cardiac Allograft Survival
J. Exp. Med., March 18, 2002; 195(6): 795 - 800.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2001 by The American Association of Immunologists, Inc. All rights reserved.