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,
,
Departments of
*
Surgery,
Pathology, and
Molecular Virology, Immunology, and Medical Genetics, and
Comprehensive Cancer Center, Ohio State University College of Medicine, Columbus, OH 43210
It was shown >20 yr ago that mice will spontaneously accept renal
allografts in the absence of immunosuppression, but the mechanism
responsible for this is not understood. We transplanted DBA/2
(H-2d) kidneys into nephrectomized C57BL/6
(H-2b) mice, and the allografts were spontaneously accepted
for >60 days without immunosuppression. In contrast,
nonimmunosuppressed cardiac and skin allografts in the same strain
combination are rejected within approximately 10 days. The accepted
renal allografts have a prominent leukocytic infiltrate, suggesting an
ongoing, local immune response. At 60 days post-transplant, the
recipients of accepted renal allografts display DBA/2-reactive
alloantibodies. They also display DBA/2-reactive delayed-type
hypersensitivity responses that are actively counter-regulated by
DBA/2-induced TGF-
production, but not by IL-10 production. These
data suggest that a donor-reactive, cell-mediated immune mechanism
involving TGF- is associated with the spontaneous acceptance of
renal allografts in mice.
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