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*
Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences and The Ela Kodesz Institute for Research on Cancer Development and Prevention, Tel Aviv University, Tel Aviv, Israel;
Pediatric Hemato-Oncology Department, Chaim Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel-Hashomer, Israel
The homing of hemopoietic stem cells to the bone marrow is mediated
by specific interactions occurring between CXCR4, which is expressed on
hemopoietic stem cells, and its ligand, stromal cell-derived factor-1
(SDF-1), a CXC chemokine secreted by bone marrow stromal cells. In the
present study we evaluated the possibility that neuroblastoma cells use
a mechanism similar to that used by hemopoietic stem cells to home to
the bone marrow and adhere to bone marrow stromal cells. Our study
suggests that CXCR4 expression may be a general characteristic of
neuroblastoma cells. SH-SY5Y neuroblastoma cells express not only
CXCR4, but also its ligand, SDF-1. CXCR4 expression on SH-SY5Y
neuroblastoma cells is tightly regulated by tumor cell-derived SDF-1,
as demonstrated by the ability of neutralizing Abs against human
SDF-1
to up-regulate CXCR4 expression on the tumor cells. The
reduction in CXCR4 expression following short term exposure to
recombinant human SDF-1 can be recovered as a result of de novo
receptor synthesis. Recombinant human SDF-1 induces the migration of
CXCR4-expressing SH-SY5Y neuroblastoma cells in CXCR4- and
heterotrimeric G protein-dependent manners. Furthermore, SH-SY5Y cells
interact at multiple levels with bone marrow components, as evidenced
by the fact that bone marrow-derived constituents promote SH-SY5Y cell
migration, adhesion to bone marrow stromal cells, and proliferation.
These results suggest that SH-SY5Y neuroblastoma cells are equipped
with adequate machinery to support their homing to the bone marrow.
Therefore, the ability of neuroblastoma tumors to preferentially form
metastases in the bone marrow may be influenced by a set of complex
CXCR4-SDF-1 interactions.
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R. Sadir, A. Imberty, F. Baleux, and H. Lortat-Jacob Heparan Sulfate/Heparin Oligosaccharides Protect Stromal Cell-derived Factor-1 (SDF-1)/CXCL12 against Proteolysis Induced by CD26/Dipeptidyl Peptidase IV J. Biol. Chem., October 15, 2004; 279(42): 43854 - 43860. [Abstract] [Full Text] [PDF]
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R. A. Bartolome, B. G. Galvez, N. Longo, F. Baleux, G. N. P. van Muijen, P. Sanchez-Mateos, A. G. Arroyo, and J. Teixido Stromal Cell-Derived Factor-1{alpha} Promotes Melanoma Cell Invasion across Basement Membranes Involving Stimulation of Membrane-Type 1 Matrix Metalloproteinase and Rho GTPase Activities Cancer Res., April 1, 2004; 64(7): 2534 - 2543. [Abstract] [Full Text] [PDF]
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A. Corcione, N. Arduino, E. Ferretti, L. Raffaghello, S. Roncella, D. Rossi, F. Fedeli, L. Ottonello, L. Trentin, F. Dallegri, et al. CCL19 and CXCL12 Trigger in Vitro Chemotaxis of Human Mantle Cell Lymphoma B Cells Clin. Cancer Res., February 1, 2004; 10(3): 964 - 971. [Abstract] [Full Text] [PDF]
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A. Letsch, U. Keilholz, G. Assfalg, V. Mailander, E. Thiel, and C. Scheibenbogen Bone Marrow Contains Melanoma-reactive CD8+ Effector T Cells and, Compared with Peripheral Blood, Enriched Numbers of Melanoma-reactive CD8+ Memory T Cells Cancer Res., September 1, 2003; 63(17): 5582 - 5586. [Abstract] [Full Text] [PDF]
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 R. J. Phillips, M. D. Burdick, M. Lutz, J. A. Belperio, M. P. Keane, and R. M. Strieter The Stromal Derived Factor-1/CXCL12-CXC Chemokine Receptor 4 Biological Axis in Non-Small Cell Lung Cancer Metastases Am. J. Respir. Crit. Care Med., June 15, 2003; 167(12): 1676 - 1686. [Abstract] [Full Text] [PDF]
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T. Papayannopoulou, G. V. Priestley, H. Bonig, and B. Nakamoto The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization Blood, June 15, 2003; 101(12): 4739 - 4747. [Abstract] [Full Text] [PDF]
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G. Dontu, W. M. Abdallah, J. M. Foley, K. W. Jackson, M. F. Clarke, M. J. Kawamura, and M. S. Wicha In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells Genes & Dev., May 15, 2003; 17(10): 1253 - 1270. [Abstract] [Full Text] [PDF]
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T. Murakami, W. Maki, A. R. Cardones, H. Fang, A. Tun Kyi, F. O. Nestle, and S. T. Hwang Expression of CXC Chemokine Receptor-4 Enhances the Pulmonary Metastatic Potential of Murine B16 Melanoma Cells Cancer Res., December 1, 2002; 62(24): 7328 - 7334. [Abstract] [Full Text] [PDF]
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C. J. Scotton, J. L. Wilson, K. Scott, G. Stamp, G. D. Wilbanks, S. Fricker, G. Bridger, and F. R. Balkwill Multiple Actions of the Chemokine CXCL12 on Epithelial Tumor Cells in Human Ovarian Cancer Cancer Res., October 15, 2002; 62(20): 5930 - 5938. [Abstract] [Full Text] [PDF]
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T. Hideshima, D. Chauhan, T. Hayashi, K. Podar, M. Akiyama, D. Gupta, P. Richardson, N. Munshi, and K. C. Anderson The Biological Sequelae of Stromal Cell-derived Factor-1{alpha} in Multiple Myeloma Mol. Cancer Ther., May 1, 2002; 1(7): 539 - 544. [Abstract] [Full Text] [PDF]
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R. S. Taichman, C. Cooper, E. T. Keller, K. J. Pienta, N. S. Taichman, and L. K. McCauley Use of the Stromal Cell-derived Factor-1/CXCR4 Pathway in Prostate Cancer Metastasis to Bone Cancer Res., March 1, 2002; 62(6): 1832 - 1837. [Abstract] [Full Text] [PDF]
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